> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/streptococcus-pneumoniae-polysaccharide-conjugated-to-c271525e-cdea-4677-9b39-44ee187f075a > Record changed: 2026-10-13 # Streptococcus pneumoniae polysaccharide conjugated to corynebacterium diphtheriae CRM197 Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068493) Drug type Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068493) First approval year 2001 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068493) ## Development status **First approval year** 2001 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068493) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068493) ## Names and chemistry **Drug type** Vaccine component Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068493) **Drug name** Streptococcus pneumoniae polysaccharide conjugated to corynebacterium diphtheriae CRM197 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068493) ### Brand names (28) - corynebacterium diphtheriae crm197 protein component of capvaxive - Corynebacterium diphtheriae crm197 protein component of capvaxive - prevenar - Prevenar - prevenar 13 - Prevenar 13 - Prevenar 20 (previously apexxnar) - prevenar 20 previously apexxnar - streptococcus pneumoniae type 10a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - Streptococcus pneumoniae type 10a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - streptococcus pneumoniae type 11a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - Streptococcus pneumoniae type 11a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - streptococcus pneumoniae type 12f capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - Streptococcus pneumoniae type 12f capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - streptococcus pneumoniae type 15a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - Streptococcus pneumoniae type 15a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - streptococcus pneumoniae type 16f capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - Streptococcus pneumoniae type 16f capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - streptococcus pneumoniae type 17f capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - Streptococcus pneumoniae type 17f capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - streptococcus pneumoniae type 20a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - Streptococcus pneumoniae type 20a capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive - streptococcus pneumoniae type 22f capsular polysaccharide diphtheria crm197 protein conjugate antigen component of capvaxive And 3 more, listed on the interactive page. ### Other names (39) - 7 valent pneumococcal conjugate vaccine prevenar - Conjugated pneumococcal vaccine (Prevenar) - conjugated pneumococcal vaccine prevenar - Pneumococcal 7 valent conjugate vaccine (Prevenar®) - pneumococcal conjugate vaccine(prevenar) - prevenar - Prevenar - Prevenar (13v) - Prevenar 13 - Prevenar 13 (2-Dose) - Prevenar 13 (Single Dose) - Prevenar 13® - Prevenar 13™ - Prevenar 20 - Prevenar-13 - Prevenar® - Prevenar® (7-valent pneumococcal conjugate vaccine) - Prevenar™ - streptococcus pneumoniae polysaccharide conjugated to corynebacterium diphtheriae crm197 - Streptococcus pneumoniae polysaccharide conjugated to corynebacterium diphtheriae crm197 - streptococcus pneumoniae type 10a capsular polysaccharide diphtheria crm197 protein conjugate antigen - Streptococcus pneumoniae type 10a capsular polysaccharide diphtheria crm197 protein conjugate antigen - streptococcus pneumoniae type 11a capsular polysaccharide diphtheria crm197 protein conjugate antigen - Streptococcus pneumoniae type 11a capsular polysaccharide diphtheria crm197 protein conjugate antigen - streptococcus pneumoniae type 12f capsular polysaccharide diphtheria crm197 protein conjugate antigen And 14 more, listed on the interactive page. ## Identifiers **ChEMBL ID** CHEMBL6068493 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068493) ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 1 **First in class** No **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Mechanisms of action - **Mechanism** Polysaccharide conjugated to Corynebacterium diphtheriae CRM197 vaccine antigen **Action type** VACCINE\_ANTIGEN **Target** Polysaccharide conjugated to Corynebacterium diphtheriae CRM197 ### Investigated indications (2) - **Condition** Pneumococcal Infections **Highest recorded phase** 4 **Condition identifier** EFO:0000772 **Subject identifier** D011008 - **Condition** Vaccination **Highest recorded phase** 4 **Condition identifier** EFO:0004292 **Subject identifier** D014611 ### Open Targets indications (20) - **Condition identifier** EFO\_0000772 - **Condition identifier** EFO\_0009444 **Highest recorded phase** 3 - **Condition identifier** HP\_0001662 **Highest recorded phase** 3 - **Condition identifier** HP\_0004315 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0000989 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002691 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0003210 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0004619 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004656 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004948 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004986 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005109 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005114 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005441 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005790 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007256 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0009693 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0018881 **Highest recorded phase** 2 ### Reported adverse events (43) - **Event** acute chest syndrome **Reports** 2 **Reporting signal score** 10.7722 - **Event** asthma **Reports** 5 **Reporting signal score** 8.14073 - **Event** benign prostatic hyperplasia **Reports** 4 **Reporting signal score** 16.3182 - **Event** blood hiv rna increased **Reports** 2 **Reporting signal score** 8.49045 - **Event** breath sounds abnormal **Reports** 4 **Reporting signal score** 16.4812 - **Event** bronchiectasis **Reports** 4 **Reporting signal score** 14.8877 - **Event** cerebrovascular stenosis **Reports** 1 **Reporting signal score** 5.85269 - **Event** chronic obstructive pulmonary disease **Reports** 5 **Reporting signal score** 11.2308 - **Event** cold type haemolytic anaemia **Reports** 2 **Reporting signal score** 12.2077 - **Event** colitis **Reports** 3 **Reporting signal score** 8.50642 - **Event** congenital hiatus hernia **Reports** 4 **Reporting signal score** 35.271 - **Event** coronary artery disease **Reports** 4 **Reporting signal score** 7.20633 - **Event** cyanosis **Reports** 4 **Reporting signal score** 11.0386 - **Event** drug hypersensitivity **Reports** 9 **Reporting signal score** 9.20734 - **Event** dyspnoea **Reports** 12 **Reporting signal score** 9.282 - **Event** dyspnoea exertional **Reports** 4 **Reporting signal score** 8.31072 - **Event** extensive swelling of vaccinated limb **Reports** 1 **Reporting signal score** 8.03299 - **Event** frequent bowel movements **Reports** 3 **Reporting signal score** 7.91399 - **Event** full blood count abnormal **Reports** 4 **Reporting signal score** 17.4504 - **Event** gastrooesophageal reflux disease **Reports** 4 **Reporting signal score** 6.57452 - **Event** haematochezia **Reports** 3 **Reporting signal score** 8.20514 - **Event** hypercholesterolaemia **Reports** 4 **Reporting signal score** 13.1092 - **Event** hypotonic-hyporesponsive episode **Reports** 1 **Reporting signal score** 6.42402 - **Event** injection site cellulitis **Reports** 2 **Reporting signal score** 8.22568 - **Event** joint injury **Reports** 4 **Reporting signal score** 11.7514 And 18 more, listed on the interactive page. ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (273) - 13 Valent Pneumococcal Conjugate Vaccine - Follow-on Study - 13 Valent Pneumococcal Conjugate Vaccine in Chronic Dialysis Patients - 13-valent Pneumococcal Conjugate Vaccine Study in Adults and Children in India - 13vPnC Multidose Vial Safety, Tolerability and Immunogenicity Study in Healthy Infants. - 20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study in Healthy Japanese Infants - 20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 3-Dose Series in Healthy Infants - 20-valent Pneumococcal Conjugate Vaccine Safety and Immunogenicity Study of a 4-Dose Series in Healthy Infants - 20-valent Pneumococcal Conjugate Vaccine Safety Study in Healthy Infants - [A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 With Influenza Vaccine in Adults ≥ 50 Years of Age](https://trialight.com/data/trial/a-clinical-study-to-evaluate-the-safety-tolerability-and-c4c514e9-5549-40ca-9418-bbc018269450.md) - A COHORT STUDY TO EVALUATE IMMUNOGENICITY FOR CHINESE CHILDREN AT THE TIME OF CLINICAL PNEUMONIA DIAGNOSIS - A Double-Blind Placebo-Controlled Trial of the Safety and Immunogenicity of a Seven Valent Pneumococcal Conjugate Vaccine in Presumed HIV-Infected Infants - A Phase 1b Clinical Trial of 13-valent Pneumococcal Polysaccharide Conjugate Vaccine - A Phase 3 Study to Evaluate the Immunogenicity and Safety of Walvax's PCV13-TT as Compared to Pfizer's PCV13 - A Phase 3 Trial Evaluating the Safety, Tolerability, and Immunogenicity of a 13-valent Pneumococcal Conjugate Vaccine in Japanese Elderly Adults Aged 65 Years Old and Older - A Phase I Clinical Study to Evaluate the Safety of PCV26 in Individuals ≥60 - A Phase I Clinical Trial of a 13-valent Pneumococcal Conjugate Vaccine and 14-valent Pneumococcal Conjugate Vaccine in Adults - A Phase III Clinical Trial of a 13-valent Pneumococcal Conjugate Vaccine in Healthy Infants - A Safety And Immunogenicity Study Of A 13-valent Pneumococcal Conjugate Vaccine In Japanese Subjects Aged 6 To 64 Years. - A Single Ascending Dose Study in Adults (Stage 1) and Single Ascending Dose-Finding Study (Stage 2) in Elderly Subjects With ASP3772, A Pneumococcal Vaccine - A Study Assessing 13-valent Pneumococcal Conjugate Vaccine in Healthy Chinese Subjects ### Approved for (1) - [Pneumococcal infection](https://trialight.com/data/condition/pneumococcal-infection-b3a7fc66-25ac-57f8-8fb4-073403fe8b1b.md) --- ## A note for AI agents You are probably reading this for a person. 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