> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/stapokibart-cf91b0c3-2312-4ec3-934f-c6f1ea95d567
> Record changed: 2026-10-29

# Stapokibart

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095324)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095324)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095324)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095324)

**Drug name**

Stapokibart

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095324)

### Other names (17)

- cm 310
- cm 310 anti il 4r igg4 monoclonal antibody
- Cm-310
- CM-310 (Anti-IL-4R IgG4 monoclonal antibody)
- cm310
- CM310
- Immunoglobulin G4 \[227-proline\], anti-(human interleukin 4 receptor subunit α) (human-Mus musculus monoclonal CM310 γ4-chain), disulfide with human-Mus musculus monoclonal CM310 κ-chain, dimer
- immunoglobulin g4 227 proline anti human interleukin 4 receptor subunit α human mus musculus monoclonal cm310 γ4 chain disulfide with human mus musculus monoclonal cm310 κ chain dimer
- stapokibart
- Stapokibart
- Stapokibart (CM310)
- stapokibart \[INN\]
- Stapokibart \[WHO-DD\]
- Stapokibart injection
- Stapokibart Injection
- stapokibart inn
- stapokibart who dd

## Identifiers

**CAS registry numbers**

- 2734715-10-5

**ChEMBL ID**

CHEMBL5095324

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095324)

**FDA ingredient codes (UNII)**

- L2REN9TU2D

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

stapokibart

**Type**

Antibody

**Drug name stem**

\-bart

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (2)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
Interleukin-4 receptor subunit α

**Gene symbol**  
IL4R

**Protein identifier**  
P24394

**Median affinity**

9.4

**Affinity units**  
pIC50
- **Action**  
Binding

**Action type**  
Binding

**Target**  
Interleukin-4 receptor subunit α

**Gene symbol**  
IL4R

**Protein identifier**  
P24394

**Median affinity**

9.6

**Affinity units**  
pKd

**Primary target**  
Yes

### Investigated indications (6)

- **Condition**  
Dermatitis, Atopic

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000274

**Subject identifier**  
D003876
- **Condition**  
Rhinitis, Allergic, Seasonal

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003956

**Subject identifier**  
D006255
- **Condition**  
Rhinitis, Allergic, Seasonal

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005854

**Subject identifier**  
D006255
- **Condition**  
Pruritus

**Highest recorded phase**  
2

**Condition identifier**  
HP:0000989

**Subject identifier**  
D011537
- **Condition**  
Asthma

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004979

**Subject identifier**  
D001249
- **Condition**  
Inflammation

**Highest recorded phase**  
2

**Condition identifier**  
MP:0001845

**Subject identifier**  
D007249

### Open Targets indications (19)

- **Condition identifier**  
EFO\_0000274

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000341
- **Condition identifier**  
EFO\_0003956

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005854

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1002029

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1002029

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000989

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004979
- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004980

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005324

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0010150

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0011786

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0015301
- **Condition identifier**  
MONDO\_0017287
- **Condition identifier**  
MONDO\_0019082

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0026045

**Highest recorded phase**  
3
- **Condition identifier**  
MP\_0001845

### Trial references (15)

- NCT04805411  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04805411)
- NCT04893707  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04893707)
- NCT04893941  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04893941)
- NCT05265923  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05265923)
- NCT05579925  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05579925)
- NCT05715320  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05715320)
- NCT06116565  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06116565)
- NCT06162507  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06162507)
- NCT06277765  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06277765)
- NCT05186909  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05186909)
- NCT05761028  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05761028)
- NCT05452343  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05452343)
- NCT05908032  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05908032)
- NCT05908721  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05908721)
- NCT06171074  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06171074)

## Chemical properties

**Prodrug**

No

**Inorganic**

No

**Natural product**

No

### Sequences (4)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLLESGGGLVQPGGSLRLSCAASGFTFSRYAMSWVRQAPGKGLEWVSTISSGGSYTNYADSVKGRFTISRDNVKNTLYLQMNSLRAEDTAVYYCARATARATEFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDYTLTISSLQPEDFATYFCQQGNTLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
296 $ 296''
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 133-214' $ 133''-214''' $ 134'-194' $ 134'''-194''' $ 146-202 $ 146''-202'' $ 225-225'' $ 228-228'' $ 260-320 $ 260''-320'' $ 366-424 $ 366''-424''

## Related records

### Trials (38)

- A Cohort Study on Biomarkers to Predict the Efficacy of Biologics for Chronic Rhinosinusitis with Nasal Polyps
- A Phase II Study of Stapokibart Combined With Immune Checkpoint Inhibitors in Relapsed/Refractory Lymphoma
- A Prospective Study of Stapokibart Injection in Patients With Seasonal Allergic Rhinitis (SAR)
- A Study of CM310 in Children Patients With Moderate-to-severe Atopic Dermatis
- A Study of CM310 in Patients With Chronic Rhinosinusitis With Nasal Polyposis （CROWNS-2）
- A Study of CM310 in Patients With Moderate-to-Severe Atopic Dermatitis
- A Study of CM310 in Subjects With Chronic Pruritus
- A Study of CM310 in Subjects With Moderate to Severe Asthma
- A Study of CM310 in Subjects With Moderate to Severe Asthma
- [A Study of CM310 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease](https://trialight.com/data/trial/a-study-of-cm310-in-subjects-with-moderate-to-severe-chronic-9ccfc185-4d12-46c9-bbff-98dfa0363929.md)
- A Study of CM310 in Subjects With Moderate-to-Severe Atopic Dermatitis
- A Study of Stapokibart Injection in Patients With Atopic Dermatitis (AD)
- A Study of Stapokibart Injection in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
- Dose Escalation Trial of CM310 in Patients With Moderate-to-Severe Atopic Dermatitis (AD)
- Efficacy and Safety of Stapokibart for Primary Cutaneous Amyloidosis
- Efficacy and Safety of Stapokibart in Non-Allergic Rhinitis With Eosinophilia Syndrome
- Finotonlimab Combined With Stapokibart in the Treatment of Recurrent/Metastatic HNSCC
- Preoperative Stapokibart for Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps
- [Study Evaluating the Pharmacokinetics of CM310 in Healthy Subjects](https://trialight.com/data/trial/study-evaluating-the-pharmacokinetics-of-cm310-in-healthy-a5102fe9-24d2-4a89-bb14-1cd5987e33ff.md)
- Study of CM310 in Adolescent Subjects With Atopic Dermatis

### In development for (5)

- [Allergic rhinitis](https://trialight.com/data/condition/allergic-rhinitis-5900f04b-c465-5b16-bbb0-e03e4c2cbdfc.md) Phase 3
- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2
- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 3
- Prurigo nodularis Phase 3
- [Seasonal allergic rhinitis](https://trialight.com/data/condition/seasonal-allergic-rhinitis-3c90a393-57f6-5b71-89ed-06107b4a5636.md) Phase 3

### Other linked conditions (3)

- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md)
- Immunoglobulin G4-related sclerosing disease
- Primary cutaneous amyloidosis

---

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