> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/spunoleucel-3e670e80-ab3a-49e2-8479-bf7835c06da2 > Record changed: 2026-10-13 # Spunoleucel Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068442) Drug type Cell Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068442) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068442) ## Names and chemistry **Drug type** Cell Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068442) **Drug name** Spunoleucel Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068442) ### Other names (21) - allogeneic multi virus specific t lymphocytes targeting respiratory syncytial virus rsv influenza parainfluenza virus piv and human metapneumovirus hmpv - Allogeneic Multi-Virus Specific T Lymphocytes Targeting Respiratory Syncytial Virus (RSV), Influenza, Parainfluenza Virus (PIV), and Human Metapneumovirus (hMPV) - alv 106 - ALV-106 - alv106 - ALV106 - alvr106 - ALVR106 - alvr106 is a novel virus specific cell based therapy to treat four respiratory viral infections that are a serious cause of morbidity and mortality in immunocompromised patients alvr106 is under development to treat four respiratory viral infections respiratory syncytial virus influenza parainfluenza virus and human metapneumovirus that are common and of significant clinical concern in immunocompromised patients including those who have undergone hematopoietic stem cell transplantation solid organ transplantation as well as in vulnerable elderly and pediatric populations - ALVR106 is a novel virus-specific cell-based therapy to treat four respiratory viral infections that are a serious cause of morbidity and mortality in immunocompromised patients. ALVR106 is under development to treat four respiratory viral infections (respiratory syncytial virus, influenza, parainfluenza virus and human metapneumovirus) that are common and of significant clinical concern in immunocompromised patients, including those who have undergone hematopoietic stem cell transplantation, solid organ transplantation, as well as in vulnerable elderly and pediatric populations - ALVR106 is a polyclonal (CD4+ and CD8+) virus-specific T cell product containing cells that are reactive against four viruses (RSV, Influenza, PIV, and hMPV). The cells are derived from peripheral blood mononuclear cells (PBMCs) from donors seropositive for all four of these viruses - alvr106 is a polyclonal cd4 and cd8 virus specific t cell product containing cells that are reactive against four viruses rsv influenza piv and hmpv the cells are derived from peripheral blood mononuclear cells pbmcs from donors seropositive for all four of these viruses - alvr106 is comprised of both cd8 and cd4 virus specific t cells capable of recognizing actively replicating virus infected cells proliferating in response to antigenic stimulation and mediating antiviral effects including the production of cytokines and effector molecules killing of infected cells in patients with infections diseases associated with the target viruses - ALVR106 is comprised of both CD8+ and CD4+ virus-specific T cells capable of recognizing actively replicating virus-infected cells, proliferating in response to antigenic stimulation and mediating antiviral effects including the production of cytokines and effector molecules, killing of infected cells in patients with infections/diseases associated with the target viruses - monovalent (RSV) unlicensed comparator - spunoleucel - Spunoleucel - spunoleucel \[INN\] - SPUNOLEUCEL \[USAN\] - spunoleucel inn - spunoleucel usan ## Identifiers **ChEMBL ID** CHEMBL6068442 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068442) **FDA ingredient codes (UNII)** - EVQ94BW5G4 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications - **Condition** Respiratory Tract Infections **Highest recorded phase** 1 **Condition identifier** MONDO:0024355 **Subject identifier** D012141 ### Open Targets indications (3) - **Condition identifier** MONDO\_0001577 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005812 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0024355 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (12) - [A Study of Investigational RSV/hMPV Combination and Investigational hMPV Vaccines in Younger and Older Adults](https://trialight.com/data/trial/a-study-of-investigational-rsv-hmpv-combination-and-6ccee9c3-5c26-4b27-9fb5-f75c55ad1d38.md) - [A Study on the Safety and Immunogenicity of Influenza, Respiratory Syncytial Virus, Human Metapneumovirus and Parainfluenza Vaccines in Adults 18 to 49 Years of Age.](https://trialight.com/data/trial/a-study-on-the-safety-and-immunogenicity-of-influenza-ba8ae036-0d91-4d40-b31a-2520da63dde1.md) - Evaluation of RSV/Flu-01E Vaccine for the Prevention of RSV Infection in Volunteers Aged 18 to 59 Years and Over 60 Years - [Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older](https://trialight.com/data/trial/phase-1-2-study-of-respiratory-syncytial-virus-and-human-4fdfa90c-47bc-4f3a-b1df-53072b0fb30d.md) - Phase 2 Study of the RSV/Flu-01E Vaccine Against Respiratory Syncytial Virus Infection in Older Adults - Safety of RSV Preventive Monoclonal Antibody - [Study of a Respiratory Syncytial Virus/Human Metapneumovirus Vaccine Candidate](https://trialight.com/data/trial/study-of-a-respiratory-syncytial-virus-human-metapneumovirus-7e9d5aa4-968e-4e1a-a4e4-5fb56ae43c54.md) - [Study of a Respiratory Syncytial Virus/Human Metapneumovirus/Parainfluenza Virus Type 3 Vaccine Candidate in Adults Aged 60 Years and Older](https://trialight.com/data/trial/study-of-a-respiratory-syncytial-virus-human-metapneumovirus-791f9312-b59e-44a6-8c99-e47d7b033f7d.md) - Study of ALVR106 in Patients With Respiratory Viral Infections After Hematopoietic Cell and Solid Organ Transplant - [Study of an RSV-hMPV-PIV3 Trivalent Vaccine Candidate VXB-251 in Older Adults](https://trialight.com/data/trial/study-of-an-rsv-hmpv-piv3-trivalent-vaccine-candidate-vxb-9f64287e-bc0e-4006-bbce-5ad08556366e.md) - [Study of the Safety and Immune Response of an Investigational mRNA Vaccine for the Prevention of Respiratory Syncytial Virus and/or Human Metapneumovirus in Participants Aged 18 to 49 Years and 60 Years and Older](https://trialight.com/data/trial/study-of-the-safety-and-immune-response-of-an-61db004f-a07f-4f37-97ff-4703ebcb05f3.md) - [Study to Evaluate the Safety and Immune Response of an Investigational Vaccine for the Prevention of RSV (Respiratory Syncytial Virus) and (hMPV) Human Metapneumovirus Infection in Participants Aged 60 to 75 Years](https://trialight.com/data/trial/study-to-evaluate-the-safety-and-immune-response-of-an-a60fa02e-519f-4897-b84a-0e44914c9f57.md) ### In development for (1) - [Respiratory tract infectious disorder](https://trialight.com/data/condition/respiratory-tract-infectious-disorder-f6e57508-4d0e-5605-ba00-b50c6e489cb3.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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