Sonesitatug vedotin
Highest phase reached
Phase 2
Drug type
Antibody
- Listing at source
- Listed
- Highest phase reached
- Phase 2
- Drug type
- Antibody
- Drug name
- Sonesitatug vedotin
- an anti claudin 18 2 monoclonal antibody conjugated with mmae payload
- An anti-Claudin 18.2 monoclonal antibody conjugated with MMAE payload
- azd0901
- AZD0901
- cmg 901
- CMG 901 [WHO-DD]
- cmg 901 who dd
- CMG-901
- h gamma1 heavy chain humanized 1 448 vh homo sapiens ighv4 59 11 94 8 ighd ighj4 01 92 9 cdr imgt 9 7 11 26 34 52 58 97 107 1 118 homo sapiens ighg1 03 100 g1m3 ng1m1 ch1 r120 ch3 e12 m14 ch1 r120 215 119 216 hinge 1 15 217 231 ch2 232 341 ch3 e12 357 m14 359 342 446 chs 447 448 119 448 221 220 disulfide with l kappa light chain humanized 1 220 v kappa homo sapiens igkv4 1 01 92 1 igkj1 01 100 cdr imgt 12 3 9 27 38 56 58 95 103 1 113 homo sapiens igkc 01 100 km3 a45 1 v101 c kappa a45 1 159 v101 197 114 220 dimer 227 227 230 230 bisdisulfide produced in chinese hamster ovary cho cells derived from the cell line cho k1 lacking the glutamine synthetase gs ko gene glycoform alfa substituted at the sulfur atoms of four l cysteinyl residues on an average among 221 227 230 220 221 227 230 and 220 with a group consisting of 3rs 1 6 2s 1 2s 5 carbamoylamino 1 4 2s 1 2s 1 3r 4s 5s 1 2s 2 1r 2r 3 1s 2r 1 hydroxy 1 phenylpropan 2 yl amino 1 methoxy 2 methyl 3 oxopropyl pyrrolidin 1 yl 3 methoxy 5 methyl 1 oxoheptan 4 yl methyl amino 3 methyl 1 oxobutan 2 yl amino 3 methyl 1 oxobutan 2 yl methyl carbamoyl oxy methyl anilino 1 oxopentan 2 yl amino 3 methyl 1 oxobutan 2 yl amino 6 oxohexyl 2 5 dioxopyrrolidin 3 yl vedotin
- H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV4-59*11 (94.8%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [9.7.11] (26-34.52-58.97-107)) (1-118) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 E12 (357), M14 (359) (342-446), CHS (447-448)) (119-448)], (221-220')-disulfide with L-kappa light chain humanized (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (92.1%) -IGKJ1*01 (100%), CDR-IMGT [12.3.9] (27'-38'.56'-58'.95'-103')) (1'-113') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (159'), V101 (197')) (114'-220')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa; substituted at the sulfur atoms of four L -cysteinyl residues on an average among 221, 227, 230, 220', 221'', 227'', 230'' and 220''' with a group consisting of (3RS)-1-(6-{[(2S)-1-{[(2S)-5-(carbamoylamino)-1-{4-[({[(2S)-1-{[(2S)-1-{[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)amino}-3-methyl-1-oxobutan-2-yl]amino}-3-methyl-1-oxobutan-2-yl](methyl)carbamoyl}oxy)methyl]anilino}-1-oxopentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]amino}-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl (vedotin)
- immunoglobulin g1 anti human claudin cldn18 human mus musculus monoclonal cm311 γ1 chain disulfide with human mus musculus monoclonal cm311 κ chain dimer thioether with n 4 n 6 3 mercapto 2 5 dioxo 1 pyrrolidinyl 1 oxohexyl l valyl n5 aminocarbonyl l ornithyl amino phenyl methoxy carbonyl n methyl l valyl n 1s 2r 4 2s 2 1r 2r 3 1r 2s 2 hydroxy 1 methyl 2 phenylethyl amino 1 methoxy 2 methyl 3 oxopropyl 1 pyrrolidinyl 2 methoxy 1 1s 1 methylpropyl 4 oxobutyl n methyl l valinamide
- immunoglobulin g1 kappa anti homo sapiens cldn18 claudin 18 claudin 18 surfactant associated protein j sftpj isoform 2 humanized monoclonal antibody conjugated on an average of four cysteinyl residues to vedotin comprising a cleavable linker and monomethylauristatin e mmae
- immunoglobulin g1 kappa anti homo sapiens cldn18 claudin 18 claudin 18 surfactant associated protein j sftpj isoform 2 humanized monoclonal antibody conjugated on an average of four cysteinyl residues to vedotin comprising a cleavable linker and monomethylauristatin e mmae h gamma1 heavy chain humanized 1 448 vh homo sapiens ighv4 59 11 94 8 ighd ighj4 01 92 9 cdr imgt 9 7 11 26 34 52 58 97 107 1 118 homo sapiens ighg1 03 100 g1m3 ng1m1 ch1 r120 ch3 e12 m14 ch1 r120 215 119 216 hinge 1 15 217 231 ch2 232 341 ch3 e12 357 m14 359 342 446 chs 447 448 119 448 221 220 disulfide with l kappa light chain humanized 1 220 v kappa homo sapiens igkv4 1 01 92 1 igkj1 01 100 cdr imgt 12 3 9 27 38 56 58 95 103 1 113 homo sapiens igkc 01 100 km3 a45 1 v101 c kappa a45 1 159 v101 197 114 220 dimer 227 227 230 230 bisdisulfide produced in chinese hamster ovary cho cells derived from the cell line cho k1 lacking the glutamine synthetase gs ko gene glycoform alfa substituted at the sulfur atoms of four l cysteinyl residues on an average among 221 227 230 220 221 227 230 and 220 with a group consisting of 3rs 1 6 2s 1 2s 5 carbamoylamino 1 4 2s 1 2s 1 3r 4s 5s 1 2s 2 1r 2r 3 1s 2r 1 hydroxy 1 phenylpropan 2 yl amino 1 methoxy 2 methyl 3 oxopropyl pyrrolidin 1 yl 3 methoxy 5 methyl 1 oxoheptan 4 yl methyl amino 3 methyl 1 oxobutan 2 yl amino 3 methyl 1 oxobutan 2 yl methyl carbamoyl oxy methyl anilino 1 oxopentan 2 yl amino 3 methyl 1 oxobutan 2 yl amino 6 oxohexyl 2 5 dioxopyrrolidin 3 yl
- immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ) isoform 2], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker and monomethylauristatin E (MMAE)
- Immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ) isoform 2], humanized monoclonal antibody, conjugated on an average of four cysteinyl residues to vedotin, comprising a cleavable linker and monomethylauristatin E (MMAE); H-gamma1 heavy chain humanized (1-448) [VH (Homo sapiens IGHV4-59*11 (94.8%) -(IGHD) -IGHJ4*01 (92.9%), CDR-IMGT [9.7.11] (26-34.52-58.97-107)) (1-118) -Homo sapiens IGHG1*03 (100%) G1m3, nG1m1 CH1 R120, CH3 E12, M14 (CH1 R120 (215) (119-216), hinge 1-15 (217-231), CH2 (232-341), CH3 E12 (357), M14 (359) (342-446), CHS (447-448)) (119-448)], (221-220')-disulfide with L-kappa light chain humanized (1'-220') [V-KAPPA (Homo sapiens IGKV4-1*01 (92.1%) -IGKJ1*01 (100%), CDR-IMGT [12.3.9] (27'-38'.56'-58'.95'-103')) (1'-113') -Homo sapiens IGKC*01 (100%) Km3 A45.1, V101 (C-KAPPA A45.1 (159'), V101 (197')) (114'-220')]; dimer (227-227'':230-230'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, lacking the glutamine synthetase (GS-KO) gene, glycoform alfa; substituted at the sulfur atoms of four L-cysteinyl residues on an average among 221, 227, 230, 220', 221'', 227'', 230'' and 220''' with a group consisting of (3RS)-1-(6-{[(2S)-1-{[(2S)-5-(carbamoylamino)-1-{4-[({[(2S)-1-{[(2S)-1-{[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)amino}-3-methyl-1-oxobutan-2-yl]amino}-3-methyl-1-oxobutan-2-yl](methyl)carbamoyl}oxy)methyl]anilino}-1-oxopentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]amino}-6-oxohexyl)-2,5-dioxopyrrolidin-3-yl
- Immunoglobulin G1, anti-(human claudin CLDN18) (human-Mus musculus monoclonal CM311 γ1-chain), disulfide with human-Mus musculus monoclonal CM311 κ-chain, dimer, thioether with N-[[[4-[[N-[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
- sonesitatug vedotin
- Sonesitatug vedotin
- Sonesitatug Vedotin
- sonesitatug vedotin [INN]
- SONESITATUG VEDOTIN [USAN]
- sonesitatug vedotin inn
- sonesitatug vedotin usan
- sonesitatug vedotina
- Sonesitatug vedotina
And 2 more, listed on the interactive page.
- CAS registry numbers
- 2813237-93-1
- ChEMBL ID
- CHEMBL6068297
- FDA ingredient codes (UNII)
- 96ZG83EF42
- First in class
- No
- Orphan designation
- No
- Drug name stem
- -dotin
Investigated indications
- Condition
- Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000616
- Subject identifier
- D009369
- Condition identifier
- EFO_0000616
- Condition identifier
- MONDO_0003219
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005028
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005036
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005070
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Natural product
- No
- Component
- Heavy chain
- Type
- Protein
- Sequence
- QUALESGPGLVKPSETLSLICTUSGGSISSNYAWNWIRQPPKGLEWIGYIYYSGNTNYNPSLKSRVTISRDTSKNQESLKLSSVTAADTAVYYCATSYYGNSEIYWGQGTLVIVSSASTKGPSVEPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGHTFPAVLQSSGIYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELIGGPSVELFPPKPKDILMISRIPEVICVVVDSHEDPEVKENWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVIHQDWINGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYILPPSREEMTKNQVSLTCLYKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSEFLYSKLTDKSRWQQGNVESCSVMHEALHNHYTQKSLSLSPGK
- Component
- Disulfide bridges
- Sequence
- 22-96 $ 22''-96 $ 23'-94' $ 23'''-94''' $ 140'-200' $ 140'''-200''' $ 145-201 $ 145''-201'' $ 221-220' $ 221''-220''' $ 227-227'' $ 230-230'' $ 252-322 $ 262''-322'' $ 368-426 $ 368''-426''
- Component
- Light chain
- Type
- Protein
- Sequence
- DIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQKNYLTWYQQKPGOPPKLLIYWASTRESGVPDRESGSGSGTDETLTISSLQAEDVAVYYCQNAYSEPWTFGQGTKVEIKRTVAAPSVEIFPPSDEQIKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSENRGEC
- Component
- Glycosylation sites (N)
- Sequence
- 298 $ 298''
Related records
Trials (7)
- A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
- A Study to Investigate the Effects of AZD0901 Monotherapy in Adult Participants With 2L+ Advanced or Metastatic Gastric or GEJ Adenocarcinoma Expressing CLDN18.2
- AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2
- AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2
- Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
- Perioperative Therapies in Locally Advanced Unresectable Gastric Cancer
- Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
In development for (1)
- Neoplasm Phase 2