> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/sonavibart-f85c5f86-9785-423b-8adf-e1a07f568154 > Record changed: 2026-10-13 # Sonavibart Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068464) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068464) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068464) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068464) **Drug name** Sonavibart Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068464) ### Other names (19) - h gamma1 heavy chain homo sapiens 1 458 vh homo sapiens ighv6 1 01 95 0 ighd ighj3 02 93 8 cdr imgt 10 9 18 26 35 53 61 100 117 1 128 homo sapiens ighg1 03 g1m3 ng1m1 ch1 r120 ch3 e12 m14 g1v24 ch3 l107 s114 ch1 r120 225 129 226 hinge 1 15 227 241 ch2 242 351 ch3 e12 367 m14 369 m107 l 439 n114 s 445 352 456 chs 457 458 129 458 231 210 disulfide with l kappa light chain homo sapiens 1 210 v kappa homo sapiens igkv1 39 01 91 4 igkj1 01 100 cdr imgt 6 3 5 27 32 50 52 89 93 1 103 homo sapiens igkc 01 100 km3 a45 1 149 v101 187 104 210 dimer 237 237 240 240 bisdisulfide produced in chinese hamster ovary cho cells cell line cho k1 glycoform alfa - H-gamma1 heavy chain Homo sapiens (1-458) \[VH (Homo sapiens IGHV6-1\*01 (95.0%) -(IGHD) -IGHJ3\*02 (93.8%), CDR-IMGT \[10.9.18\] (26-35.53-61.100-117)) (1-128) -Homo sapiens IGHG1\*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v24 CH3 L107, S114 (CH1 R120 (225) (129-226), hinge 1-15 (227-241), CH2 (242-351), CH3 E12 (367), M14 (369), M107>L (439), N114>S (445) (352-456), CHS (457-458)) (129-458)\], (231-210')-disulfide with L-kappa light chain Homo sapiens (1'-210') \[V-KAPPA (Homo sapiens IGKV1-39\*01 (91.4%) -IGKJ1\*01 (100%), CDR-IMGT \[6.3.5\] (27'-32'.50'-52'.89'-93')) (1'-103') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (149'), V101 (187') (104'-210')\]; dimer (237-237'':240-240'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1, glycoform alfa - Immunoglobulin G1 \[439-leucine,445-serine\], anti-(influenza A virus hemagglutinin) (human monoclonal VIR-2482 γ1-chain), disulfide with human monoclonal VIR-2482 κ-chain, dimer - immunoglobulin g1 439 leucine 445 serine anti influenza a virus hemagglutinin human monoclonal vir 2482 γ1 chain disulfide with human monoclonal vir 2482 κ chain dimer - immunoglobulin g1 kappa anti influenza a virus hemagglutinin ha homo sapiens monoclonal antibody sonavibart - immunoglobulin G1-kappa, anti-\[influenza A virus hemagglutinin HA\], Homo sapiens monoclonal antibody (sonavibart) - sonavibart - Sonavibart - sonavibart \[INN\] - SONAVIBART \[USAN\] - sonavibart inn - sonavibart usan - vir 2482 - Vir-2482 - VIR-2482 - VIR-2482 (1200 mg) - VIR-2482 (450 mg) - vir2482 - VIR2482 ## Identifiers **CAS registry numbers** - 2769699-23-0 **ChEMBL ID** CHEMBL6068464 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068464) **FDA ingredient codes (UNII)** - V7MT9HQR2Q ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-bart ### Investigated indications (2) - **Condition** Virus Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0000763 **Subject identifier** D014777 - **Condition** Influenza, Human **Highest recorded phase** 1 **Condition identifier** EFO:0007328 **Subject identifier** D007251 ### Open Targets indications (4) - **Condition identifier** EFO\_0000763 - **Condition identifier** EFO\_0007328 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005108 - **Condition identifier** MONDO\_0005812 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVLHEALHSHYTQKSLSLSPGK - **Component** Glycosylation sites (N) **Sequence** 308 $ 308'' - **Component** Disulfide bridges **Sequence** 22-99 $ 22''-99'' $ 23'-88' $ 23'''-88''' $ 130'-190' $ 130'''-190''' $ 155-211 $ 155''-211'' $ 231-210' $ 231''-210''' $ 237-237'' $ 240-240'' $ 272-332 $ 272''-332'' $ 378-436 $ 378''-436'' - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## Related records ### Trials (11) - A Notch Signalling Pathway Inhibitor for Patients With Advanced Breast Cancer (0752-014) - [A Phase 2 Study to Evaluate the Efficacy and Safety of VIR-2482 for the Prevention of Illness Due to Influenza A](https://trialight.com/data/trial/a-phase-2-study-to-evaluate-the-efficacy-and-safety-of-vir-0329e0e4-ef6b-4075-a4dc-53ac35f3ed60.md) - A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer - A Study of KF-0210 in Advanced Solid Tumors Patients - AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF - Evaluation of 611 in Chinese Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease - Relative Bioavailability Study of HU6 - Safety, Tolerability, Pharmacokinetics and Protective Efficacy of MAM01 in Healthy Adults - Single Ascending Oral Dose Study to Investigate the Effects of OCT461201 in Healthy Volunteers - Study of VIR-2482 in Healthy Volunteers - Study to Evaluate the Efficacy, Safety, and Tolerability of Efzofitimod in Patients With Systemic Sclerosis (SSc)-Related Interstitial Lung Disease (ILD) (SSc-ILD) ### In development for (2) - [Influenza](https://trialight.com/data/condition/influenza-ea12369b-7ed6-5f6b-94fe-eb0e56c24def.md) Phase 1 - [Viral infectious disease](https://trialight.com/data/condition/viral-infectious-disease-43db42a3-adad-5b9d-b74c-f17df0674c21.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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