> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/sodium-monofluorophosphate-9c35619e-72d7-4153-9ef4-f491755ee3e9 > Record changed: 2026-11-04 # Sodium monofluorophosphate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) First approval year 1986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) ## Development status **First approval year** 1986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) **Drug name** Sodium monofluorophosphate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) **Molecular weight** 143.95 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) **Structure (SMILES)** O=P(\[O-\])(\[O-\])F.\[Na+\].\[Na+\] Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) ### Brand names (4) - extra strength aim - Extra-strength aim - mono tridin - Mono-tridin ### Other names (26) - extra - extra fine hydrofluoroalkane beclometasone dipropionate - extra fine hydrofluoroalkane beclomethasone mdi - extra-fine hydrofluoroalkane beclometasone dipropionate - Extra-fine hydrofluoroalkane beclometasone dipropionate - Extra-fine hydrofluoroalkane beclomethasone MDI - Extra-fine hydrofluoroalkane-beclometasone dipropionate - nsc 248 - NSC-248 - phosphorofluoridic acid disodium salt - PHOSPHOROFLUORIDIC ACID, DISODIUM SALT - sodium fluorophosphate - Sodium fluorophosphate - Sodium fluorophosphate \[WHO-DD\] - sodium fluorophosphate who dd - sodium monofluorophosphate - Sodium monofluorophosphate - Sodium Monofluorophosphate - SODIUM MONOFLUOROPHOSPHATE \[MART.\] - SODIUM MONOFLUOROPHOSPHATE \[ORANGE BOOK\] - SODIUM MONOFLUOROPHOSPHATE \[USP MONOGRAPH\] - SODIUM MONOFLUOROPHOSPHATE \[USP-RS\] - sodium monofluorophosphate mart - sodium monofluorophosphate orange book - sodium monofluorophosphate usp monograph And 1 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 10163-15-2 **ChEMBL ID** CHEMBL1908359 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) **InChIKey** BFDWBSRJQZPEEB-UHFFFAOYSA-L Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) **RxNorm IDs (RxCUI)** - 56501 **FDA ingredient codes (UNII)** - C810JCZ56Q ### ATC classification codes (2) - A01AA02 - A12CD02 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908359) ### PubChem compound IDs (2) - 24266 - 66524099 ## Regulatory information ### United States **Applicant** CHESEBROUGH PONDS **Approval date** 6 Aug 1986 **Application number** NDA019518 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** discontinued ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification #### Administration routes - topical ### Investigated indications (5) - **Condition** Periodontitis **Highest recorded phase** 4 **Condition identifier** EFO:0000649 **Subject identifier** D010518 - **Condition** Dental Caries **Highest recorded phase** 4 **Condition identifier** EFO:0003819 **Subject identifier** D003731 - **Condition** Gingivitis **Highest recorded phase** 4 **Condition identifier** MONDO:0002508 **Subject identifier** D005891 - **Condition** Gingival Diseases **Highest recorded phase** 4 **Condition identifier** MONDO:0002635 **Subject identifier** D005882 - **Condition** Hypersensitivity **Highest recorded phase** 2 **Condition identifier** MONDO:0005271 **Subject identifier** D006967 ### Open Targets indications (10) - **Condition identifier** EFO\_0000649 - **Condition identifier** EFO\_0003819 - **Condition identifier** MONDO\_0002508 - **Condition identifier** MONDO\_0002508 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0002635 - **Condition identifier** MONDO\_0002635 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005076 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005271 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005276 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0006722 **Highest recorded phase** 1 ### Reported adverse events (22) - **Event** anaphylactic shock **Reports** 3 **Reporting signal score** 8.08832 - **Event** blood amylase decreased **Reports** 1 **Reporting signal score** 7.39303 - **Event** cardiac valve disease **Reports** 3 **Reporting signal score** 13.6635 - **Event** cholecystitis **Reports** 2 **Reporting signal score** 6.2962 - **Event** crest syndrome **Reports** 1 **Reporting signal score** 6.49954 - **Event** cytokine release syndrome **Reports** 4 **Reporting signal score** 15.8197 - **Event** dermatitis bullous **Reports** 3 **Reporting signal score** 10.8822 - **Event** eyelid injury **Reports** 1 **Reporting signal score** 7.19241 - **Event** fibrin d dimer increased **Reports** 2 **Reporting signal score** 8.49008 - **Event** hip fracture **Reports** 3 **Reporting signal score** 8.68149 - **Event** intercepted drug dispensing error **Reports** 2 **Reporting signal score** 10.6961 - **Event** lacrimal structure injury **Reports** 1 **Reporting signal score** 10.6887 - **Event** lipase increased **Reports** 2 **Reporting signal score** 6.30998 - **Event** liver injury **Reports** 3 **Reporting signal score** 9.09432 - **Event** oesophageal dilatation **Reports** 1 **Reporting signal score** 6.05477 - **Event** oral discomfort **Reports** 2 **Reporting signal score** 7.25279 - **Event** oral soft tissue disorder **Reports** 1 **Reporting signal score** 5.78449 - **Event** pancreatitis acute **Reports** 3 **Reporting signal score** 7.63761 - **Event** pancytopenia **Reports** 3 **Reporting signal score** 5.65028 - **Event** pharmaceutical product counterfeit **Reports** 1 **Reporting signal score** 6.70011 - **Event** sudden cardiac death **Reports** 1 **Reporting signal score** 6.35854 - **Event** upper gastrointestinal haemorrhage **Reports** 3 **Reporting signal score** 9.60234 ### Trial references (5) - NCT00762528 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00762528) - NCT00941668 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00941668) - NCT04123665 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04123665) - NCT01005966 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01005966) - NCT01831817 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01831817) ## Dosing **Dose** Pea sized amount **How often** Twice daily ### Conditions of use (2) - Supervise child's brushing and rinsing - Use only as directed by dentist or physician ## Chemical properties **Prodrug** No **Chirality** Achiral **Inorganic** Yes **Heavy atoms** 7 **Molecular formula** FNa2O3P **Monoisotopic mass** 143.93644758 **Natural product** No ## Evidence counts **Recorded assays** 14 **Active assays** 0 ## Related records ### Trials (34) - A Bleeding-Model Clinical Study - A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste - A Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity - A Clinical Study to Assess the Gingivitis and Plaque Effects of Various Dentifrices - A Clinical Study to Assess the Gingivitis Effects of Various Dentifrices - A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride - A Three Month Bleeding-Model Clinical Study - Anti-caries Potential of a Sodium Monofluorophosphate and Calcium Sodium Phosphosilicate Dentifrice - Assessing Gingivitis and Plaque From a Marketed Toothpaste - Assessing Gingivitis of 3 Different Dentifrices Compared to a Negative Control. - Brief Title: a Clinical Study to Assess Gingivitis - Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity - Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis - Compare Anti-inflammatory Dentifrices - Dentin Hypersensitivity Reduction Efficacy Clinical - Effectiveness of Arginin and Potassium Nitrate Dentifrices in Dentin Hypersensitivity Therapy - Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis. - Efficacy of Manual Toothbrushes in Removing Tooth Stains - Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period. - Evaluate Inflammation Caused by Gingivitis in Adults ### Approved for (4) - Dental caries - [Gingivitis](https://trialight.com/data/condition/gingivitis-82582680-34f0-54d2-abbe-433510e71aaa.md) - Periodontal disorder - Periodontitis ### In development for (2) - Allergic disease Phase 2 - Dental fluorosis Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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