> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/sodium-lactate-89586ecb-c116-4ea8-bc27-248b90107bcf > Record changed: 2026-11-04 # Sodium lactate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) First approval year 1982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) ## Development status **First approval year** 1982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) **Drug name** Sodium lactate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) **Molecular weight** 112.06 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) **Structure (SMILES)** CC(O)C(=O)\[O-\].\[Na+\] Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) ### Brand names (2) - sod lact co - Sod lact co ### Other names (52) - compound solution of sodium lactate - Compound solution of sodium lactate - compound solution of sodium lactate \[INN\] - compound solution of sodium lactate inn - e 325 - E-325 - e325 - E325 - ins 325 - ins no 325 - INS NO.325 - INS-325 - natrum lacticum - Natrum lacticum - NATRUM LACTICUM \[HPUS\] - natrum lacticum hpus - nsc 31718 - NSC-31718 - propanoic acid 2 hydroxy monosodium salt - PROPANOIC ACID, 2-HYDROXY-, MONOSODIUM SALT - Sodium (lactate) anhydrous - sodium dl lactate - Sodium dl-lactate - sodium lactate - Sodium lactate And 27 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 72-17-3 **ChEMBL ID** CHEMBL1357 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) **InChIKey** NGSFWBMYFKHRBD-UHFFFAOYSA-M Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1357) **PubChem compound IDs** - 23666456 **RxNorm IDs (RxCUI)** - 56489 **FDA ingredient codes (UNII)** - TU7HW0W0QT ## Regulatory information ### United States **Applicant** BAXTER HLTHCARE **Approval date** 22 Mar 1971 **Application number** NDA016682 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification #### Administration routes - Parenteral ### Investigated indications (22) - **Condition** Pancreatitis **Highest recorded phase** 3 **Condition identifier** EFO:0000278 **Subject identifier** D010195 - **Condition** Cardiovascular Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0000319 **Subject identifier** D002318 - **Condition** Wounds and Injuries **Highest recorded phase** 2 **Condition identifier** EFO:0000546 **Subject identifier** D014947 - **Condition** Stroke **Highest recorded phase** 2 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** Subarachnoid Hemorrhage **Highest recorded phase** 3 **Condition identifier** EFO:0000713 **Subject identifier** D013345 - **Condition** Scleroderma, Systemic **Highest recorded phase** 2 **Condition identifier** EFO:0000717 **Subject identifier** D012595 - **Condition** Virus Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0000763 **Subject identifier** D014777 - **Condition** Reperfusion Injury **Highest recorded phase** 2 **Condition identifier** EFO:0002687 **Subject identifier** D015427 - **Condition** Heart Failure **Highest recorded phase** 3 **Condition identifier** EFO:0003144 **Subject identifier** D006333 - **Condition** Severe Dengue **Highest recorded phase** 3 **Condition identifier** EFO:0004227 **Subject identifier** D019595 - **Condition** Hearing Loss **Highest recorded phase** 1 **Condition identifier** EFO:0004238 **Subject identifier** D034381 - **Condition** Postoperative Nausea and Vomiting **Highest recorded phase** 2 **Condition identifier** EFO:0004888 **Subject identifier** D020250 - **Condition** Hypotension **Highest recorded phase** 0.5 **Condition identifier** EFO:0005251 **Subject identifier** D007022 - **Condition** Shock, Septic **Highest recorded phase** 2 **Condition identifier** EFO:0006834 **Subject identifier** D012772 - **Condition** Intestinal Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0009431 **Subject identifier** D007410 - **Condition** Burns **Highest recorded phase** 3 **Condition identifier** EFO:0009516 **Subject identifier** D002056 - **Condition** Pancreatitis **Highest recorded phase** 3 **Condition identifier** EFO:1000652 **Subject identifier** D010195 - **Condition** Hypovolemia **Highest recorded phase** 3 **Condition identifier** HP:0011106 **Subject identifier** D020896 - **Condition** Shock **Highest recorded phase** 3 **Condition identifier** HP:0031273 **Subject identifier** D012769 - **Condition** Depressive Disorder, Major **Highest recorded phase** 2 **Condition identifier** MONDO:0002009 **Subject identifier** D003865 - **Condition** Cataract **Highest recorded phase** 2 **Condition identifier** MONDO:0005129 **Subject identifier** D002386 - **Condition** Prostatic Neoplasms, Castration-Resistant **Highest recorded phase** 2 **Condition identifier** MONDO:0008315 **Subject identifier** D064129 ### Open Targets indications (43) - **Condition identifier** EFO\_0000278 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000546 - **Condition identifier** EFO\_0000712 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000713 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000717 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000763 **Highest recorded phase** 1 - **Condition identifier** EFO\_0002687 - **Condition identifier** EFO\_0003144 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003776 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004227 **Highest recorded phase** 3 - **Condition identifier** EFO\_0004238 - **Condition identifier** EFO\_0005251 - **Condition identifier** EFO\_0006834 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009431 **Highest recorded phase** 2 - **Condition identifier** EFO\_0009516 **Highest recorded phase** 3 - **Condition identifier** EFO\_0009636 - **Condition identifier** EFO\_0011023 - **Condition identifier** EFO\_1000014 - **Condition identifier** EFO\_1000652 **Highest recorded phase** 3 - **Condition identifier** HP\_0001941 **Highest recorded phase** 4 - **Condition identifier** HP\_0002637 **Highest recorded phase** 3 - **Condition identifier** HP\_0011106 **Highest recorded phase** 3 - **Condition identifier** HP\_0031273 **Highest recorded phase** 3 - **Condition identifier** HP\_0100806 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0000440 **Highest recorded phase** 3 And 18 more, listed on the interactive page. ### Reported adverse events (27) - **Event** abdominal distension **Reports** 392 **Reporting signal score** 519.961 - **Event** abdominal pain **Reports** 345 **Reporting signal score** 96.7731 - **Event** bloody peritoneal effluent **Reports** 183 **Reporting signal score** 941.73 - **Event** device interaction **Reports** 66 **Reporting signal score** 305.539 - **Event** diabetic foot **Reports** 42 **Reporting signal score** 110.9 - **Event** dizziness **Reports** 48 **Reporting signal score** 137.173 - **Event** drug interaction **Reports** 4 **Reporting signal score** 120.935 - **Event** fatigue **Reports** 34 **Reporting signal score** 272.839 - **Event** fluid imbalance **Reports** 27 **Reporting signal score** 96.7624 - **Event** fluid overload **Reports** 419 **Reporting signal score** 1,188.61 - **Event** fluid retention **Reports** 149 **Reporting signal score** 138.456 - **Event** fungal peritonitis **Reports** 186 **Reporting signal score** 901.472 - **Event** headache **Reports** 31 **Reporting signal score** 215.66 - **Event** hernia **Reports** 99 **Reporting signal score** 174.094 - **Event** hypervolaemia **Reports** 133 **Reporting signal score** 502.627 - **Event** infectious peritonitis **Reports** 34 **Reporting signal score** 120.121 - **Event** inguinal hernia **Reports** 65 **Reporting signal score** 128.194 - **Event** noninfectious peritonitis **Reports** 42 **Reporting signal score** 188.709 - **Event** peritoneal cloudy effluent **Reports** 70 **Reporting signal score** 352.733 - **Event** peritoneal dialysis complication **Reports** 399 **Reporting signal score** 2,045.93 - **Event** peritoneal disorder **Reports** 54 **Reporting signal score** 207.46 - **Event** peritoneal effluent abnormal **Reports** 22 **Reporting signal score** 109.253 - **Event** peritonitis **Reports** 1,425 **Reporting signal score** 5,742.22 - **Event** peritonitis bacterial **Reports** 1,266 **Reporting signal score** 6,163.44 - **Event** sepsis **Reports** 196 **Reporting signal score** 114.734 And 2 more, listed on the interactive page. ### Trial references (33) - NCT00425334 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00425334) - NCT00529490 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00529490) - NCT00529711 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00529711) - NCT01981655 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01981655) - NCT02467387 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02467387) - NCT00801359 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00801359) - NCT00966628 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00966628) - NCT00995683 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00995683) - NCT02776488 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02776488) - NCT01108601 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01108601) - NCT01236833 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01236833) - NCT01433276 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01433276) - NCT04102371 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04102371) - NCT02558543 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02558543) - NCT02866552 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02866552) - NCT02641561 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02641561) - NCT03629600 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03629600) - NCT04381169 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04381169) - NCT02709044 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02709044) - NCT02821546 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02821546) - NCT02726308 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02726308) - NCT05658406 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05658406) - NCT02782520 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02782520) - NCT02807727 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02807727) - NCT03118362 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03118362) And 8 more, listed on the interactive page. ## Dosing **Route** Intraperitoneal ### Conditions of use - Select mode of therapy, frequency of treatment, formulation, fill volume, duration of dwell, and length of dialysis based on the patient’s clinical condition, fluid, electrolyte and specific needs ## Chemical properties **Prodrug** No **Chirality** Racemic **Inorganic** No **Heavy atoms** 7 **Molecular formula** C3H5NaO3 **Monoisotopic mass** 112.01363830 **Natural product** Yes ## National Drug Codes - 0264-2203 - 0264-7389 - 0264-7750 - 0264-7751 - 0338-0114 - 0338-0117 - 0338-0125 - 0338-0137 - 0338-0143 - 0338-0811 - 0941-0409 - 0941-0411 - 0941-0413 - 0941-0415 - 0941-0424 - 0941-0426 - 0941-0427 - 0941-0429 - 0941-0430 - 0941-0433 - 0941-0457 - 0941-0459 - 0941-0484 - 0941-0487 - 0941-0490 And 46 more, listed on the interactive page. ## Evidence counts **Recorded assays** 28 **Active assays** 0 ## Related records ### Trials (64) - 0.5M Na Lactate Solution in Acute Heart Failure (AHF) - A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint (TMJ) Dysfunction - A Study of hBMMSC Injection in Patients With aPAP - A Study to Assess the Effect of Intravenous Dose of (aMBMC) to Subjects With Non-ischemic Heart Failure - Aggressive Intravenous Hydration With Lactated Ringer's Solution for Prevention of Post-ESWL Pancreatitis - An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy - Balanced Crystalloids in Postpartum Hemorrhage - Biologically Modified Saphenous Vein Transplants for Improved CABG Outcomes - Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy - Crystalloids Versus Colloids During Surgery - Double Blinded Randomized Control Trial of Types of IVF in Children With DKA - Effect of Albumin Versus Routine Care on Hemodynamic Response and Stability in Patients With Preeclampsia Guided by a Non-invasive Hemodynamic Monitoring System During Cesarean Delivery With Spinal Anesthesia - Effect of Exogenous Lactate on Neurocognitive in Brain Trauma - Effect of Liberal and Restrictive IV Fluids on Recovery After Gallbladder Surgery - Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation - Effects of BRS and LRS on Postoperative Acute Kidney Injury - Efficacy of Steroid Supplementation After TMJ Rinsing for Pain Management - Efficacy, Safety of Solution Containing Hyperosmolar Sodium Lactate Infusion for Resuscitation of Patients With Hemorrhagic Shock - Evaluate the Nephrotoxicity by 6% Hydroxyethyl Starch 130/0.4 in Old Patients During Orthopaedic Surgery - Evaluation of Endoscopic Surgical Field Clarity Using Hot Saline Versus Lactated Ringer's Irrigation ### Approved for (1) - Acidosis disorder ### In development for (28) - Acute pancreatitis Phase 3 - Brain edema Phase 3 - Brain ischemia Phase 3 - Brain neoplasm Phase 3 - Burn Phase 3 - [Cardiovascular disorder](https://trialight.com/data/condition/cardiovascular-disorder-362e433e-88a4-575f-90af-50fe7239dec0.md) Phase 1 - Cataract Phase 2 - Cerebral infarction Phase 3 - Dengue hemorrhagic fever Phase 3 - Hearing loss disorder Phase 1 - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 3 - [Hypotensive disorder](https://trialight.com/data/condition/hypotensive-disorder-c7281ce5-80a4-5a6a-a6f7-bf325bd50f33.md) Early phase 1 - [Injury](https://trialight.com/data/condition/injury-4a894a73-b8a8-55e6-acf3-6e0f96e895c1.md) Phase 2 - Intestinal disorder Phase 2 - Intracranial hypertension Phase 3 - Ischemia reperfusion injury Phase 2 - [Ischemic stroke](https://trialight.com/data/condition/ischemic-stroke-22957443-39c1-55ea-8c6d-d5be07d42dc0.md) Phase 2 - [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) Phase 2 - Metabolic acidosis Phase 3 - Necrotizing enterocolitis Phase 2 ### Other linked conditions (1) - Acute kidney injury --- ## A note for AI agents You are probably reading this for a person. 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