> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/sodium-chloride-a67c33bc-45ef-42e4-8022-d121f0a86585
> Record changed: 2026-10-13

# Sodium chloride

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

First approval year

1982

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

## Development status

**First approval year**

1982

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

**Drug name**

Sodium chloride

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

**Molecular weight**

58.44

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

**Structure (SMILES)**

These details could not be displayed.

### Brand names (110)

- Aqsia (balanced salt soln)
- aqsia balanced salt soln
- askina
- Askina
- askina jet
- Askina jet
- balanced salt
- Balanced salt
- broncho saline
- Broncho saline
- Bss (balanced salt soln)
- bss balanced salt soln
- flowfusor
- Flowfusor
- fresenius
- Fresenius
- hypromellose in ringers soln
- Hypromellose in ringers soln
- Iocare (balanced salt soln)
- iocare balanced salt soln
- irriclens
- Irriclens
- isot saline
- Isot saline
- labmist

And 85 more, listed on the interactive page.

### Other names (168)

- %0.9 Saline
- 0 5 ml saline subcutaneous injection
- 0 9 nacl
- 0 9 saline
- 0 9 saline solution
- 0,9% saline
- 0,9% Saline
- 0.9 % saline
- 0.9% nacl
- 0.9% saline
- 0.9% Saline
- 0.9% saline solution
- 0.9%saline
- 1 ml saline infusion
- 5ml saline
- aqua marina
- AQUA MARINA
- AQUA MARINA \[HPUS\]
- aqua marina hpus
- b1655
- B1655
- B1655 \[LANGUAL\]
- b1655 langual
- Balanced salt solution (BSS)
- Balanced Salt Solution (BSS) Solution

And 143 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 7647-14-5

**ChEMBL ID**

CHEMBL1200574

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

**InChIKey**

FAPWRFPIFSIZLT-UHFFFAOYSA-M

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

**PubChem compound IDs**

- 5234

**RxNorm IDs (RxCUI)**

- 9863

**FDA ingredient codes (UNII)**

- 451W47IQ8X

### ATC classification codes (4)

- A12CA01
- B05CB01
- B05XA03
- S01XA03

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1200574)

## Regulatory information

### United States

**Applicant**

B BRAUN

**Approval date**

12 Aug 1970

**Application number**

NDA016733

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

#### Administration routes

- Oral
- Parenteral
- topical

### Investigated indications (448)

- **Condition**  
Acid-Base Imbalance

**Highest recorded phase**  
4

**Subject identifier**  
D000137
- **Condition**  
Fluid Therapy

**Highest recorded phase**  
4

**Subject identifier**  
D005440
- **Condition**  
HIV Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000180

**Subject identifier**  
D015658
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Myelodysplastic Syndromes

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000198

**Subject identifier**  
D009190
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Dermatitis, Atopic

**Highest recorded phase**

0.5

**Condition identifier**  
EFO:0000274

**Subject identifier**  
D003876
- **Condition**  
Atrial Fibrillation

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000275

**Subject identifier**  
D001281
- **Condition**  
Prostatic Hyperplasia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000284

**Subject identifier**  
D011470
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000305

**Subject identifier**  
D001943
- **Condition**  
Carcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000313

**Subject identifier**  
D002277
- **Condition**  
Cardiovascular Diseases

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000319

**Subject identifier**  
D002318
- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Pancreatitis, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000342

**Subject identifier**  
D050500
- **Condition**  
Heart Failure

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000373

**Subject identifier**  
D006333
- **Condition**  
Crohn Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000384

**Subject identifier**  
D003424
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000389

**Subject identifier**  
D008545
- **Condition**  
Diabetes Mellitus

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000400

**Subject identifier**  
D003920
- **Condition**  
Cardiomyopathy, Dilated

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000407

**Subject identifier**  
D002311
- **Condition**  
Carcinoma, Intraductal, Noninfiltrating

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000432

**Subject identifier**  
D002285
- **Condition**  
Emphysema

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000464

**Subject identifier**  
D004646
- **Condition**  
Epilepsy

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000474

**Subject identifier**  
D004827
- **Condition**  
Glioblastoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Hypertension

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000537

**Subject identifier**  
D006973

And 423 more, listed on the interactive page.

### Open Targets indications (498)

- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000222

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000274
- **Condition identifier**  
EFO\_0000275

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000284

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000305

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000319

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000342
- **Condition identifier**  
EFO\_0000373
- **Condition identifier**  
EFO\_0000389

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000400
- **Condition identifier**  
EFO\_0000407

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000432

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000474

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000519

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000537

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000544
- **Condition identifier**  
EFO\_0000544

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000545

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000546

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000556

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000556

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000588

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000612

**Highest recorded phase**  
3

And 473 more, listed on the interactive page.

### Reported adverse events (19)

- **Event**  
abdominal distension

**Reports**  
416

**Reporting signal score**

451.918
- **Event**  
anterior chamber cell

**Reports**  
64

**Reporting signal score**

200.737
- **Event**  
anterior chamber fibrin

**Reports**  
44

**Reporting signal score**

186.085
- **Event**  
bloody peritoneal effluent

**Reports**  
183

**Reporting signal score**

882.344
- **Event**  
device interaction

**Reports**  
66

**Reporting signal score**

284.263
- **Event**  
endophthalmitis

**Reports**  
179

**Reporting signal score**

401.595
- **Event**  
fatigue

**Reports**  
93

**Reporting signal score**

279.282
- **Event**  
fluid overload

**Reports**  
442

**Reporting signal score**  
1,136.22
- **Event**  
fungal peritonitis

**Reports**  
186

**Reporting signal score**

841.159
- **Event**  
hypervolaemia

**Reports**  
141

**Reporting signal score**

495.724
- **Event**  
hypopyon

**Reports**  
71

**Reporting signal score**

214.719
- **Event**  
noninfectious peritonitis

**Reports**  
42

**Reporting signal score**

175.192
- **Event**  
peritoneal cloudy effluent

**Reports**  
71

**Reporting signal score**

334.169
- **Event**  
peritoneal dialysis complication

**Reports**  
401

**Reporting signal score**  
1,925.07
- **Event**  
peritoneal disorder

**Reports**  
54

**Reporting signal score**

190.151
- **Event**  
peritonitis

**Reports**  
1,434

**Reporting signal score**  
5,302.55
- **Event**  
peritonitis bacterial

**Reports**  
1,266

**Reporting signal score**  
5,735.55
- **Event**  
toxic anterior segment syndrome

**Reports**  
394

**Reporting signal score**  
1,733.67
- **Event**  
ultrafiltration failure

**Reports**  
126

**Reporting signal score**

605.369

### Trial references (1,305)

- NCT00041392  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00041392)
- NCT00516178  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00516178)
- NCT00524901  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00524901)
- NCT01348971  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01348971)
- NCT01519245  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01519245)
- NCT01658410  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01658410)
- NCT01878669  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01878669)
- NCT03184155  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03184155)
- NCT05399576  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05399576)
- NCT00059332  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00059332)
- NCT00840671  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00840671)
- NCT01088230  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01088230)
- NCT01527240  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01527240)
- NCT01669408  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01669408)
- NCT02810392  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02810392)
- NCT02838589  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02838589)
- NCT03463551  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03463551)
- NCT03696121  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03696121)
- NCT04041167  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04041167)
- NCT05691244  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05691244)
- NCT05869565  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05869565)
- NCT00069082  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00069082)
- NCT00180687  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00180687)
- NCT00337597  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00337597)
- NCT00470600  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00470600)

And 1,280 more, listed on the interactive page.

## Dosing

**Dose**

Per 8 ounces

**Route**

Oral

**How often**

Every 10 minutes until 4 liters are consumed

### Conditions of use (4)

- Do not add ingredients or flavors
- Keep refrigerated for 2-8°C
- Take with water
- Use within 48 hours

## Chemical properties

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

Yes

**Heavy atoms**

2

**Molecular formula**

ClNa

**Monoisotopic mass**

57.9586220

**Natural product**

No

## National Drug Codes

- 0019-1188
- 0065-0795
- 0065-1795
- 0264-1800
- 0264-1945
- 0264-2201
- 0264-2202
- 0264-2203
- 0264-2205
- 0264-5802
- 0264-5804
- 0264-7388
- 0264-7389
- 0264-7608
- 0264-7610
- 0264-7612
- 0264-7614
- 0264-7616
- 0264-7622
- 0264-7623
- 0264-7634
- 0264-7635
- 0264-7636
- 0264-7638
- 0264-7645

And 315 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

267

**Active assays**

4

### Active assay types

- Other

## Related records

### Trials (764)

- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
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- 0,9% NaCl Effect on Kidney Function and Glycocalyx in Patients Operated on for Primary Hiparthrosis
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- 20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
- 21 Day Cumulative Skin Irritation of RUT058-60
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- A 21-Day Topical Safety Study of Diltiazem Hydrochloride Using a Cumulative Irritant Patch Test Design
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- A Clinical Study Evaluating the Dermal Safety of Soluble Denosumab Microneedle Patches
- A Clinical Study of Alanyl-Glutamine for Reduction of Post-Myomectomy Adhesions
- A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants
- A Combination Efficacy Study in Africa of Two DNA-MVA-Env Protein or DNA-Env Protein HIV-1 Vaccine Regimens With PrEP
- A Comparative Study With Parenteral Oxycodone, Morphine and Dexamethasone in Postoperative Pain in Paediatric Patients
- A Double-Blinded, Randomized Placebo Controlled Pilot Study Comparing the Efficacy and Safety of IncobotulinumtoxinA Versus Saline Injections to the Cheek Region in Patients With Rosacea
- A Heterologous 3rd COVID-19 Vaccine of MVC-COV1901 to Evaluate Immunogenicity and Safety in Adults With ChAdOx1-nCov-19
- A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade
- A Phase I, Randomized, Modified Single-blind, Active-controlled (Infants Only), Four-stage, Step-down, Comparative, Multi-center Study
- A Phase I/II Double-Blind, Randomized, Controlled Study to Evaluate the Safety and Efficacy of RUT058-60

### Approved for (6)

- Common cold
- Congestive heart failure
- Corneal edema
- [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md)
- Eye disorder
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md)

### In development for (361)

- Abscess Phase 3
- Achalasia Phase 2
- [Achondroplasia](https://trialight.com/data/condition/achondroplasia-30f8e5ac-f6be-5f3c-9878-8fd830eb5505.md) Phase 1
- [Acne](https://trialight.com/data/condition/acne-02478aa3-966b-5ffb-a257-6dbe85c14e58.md) Phase 2
- Acromegaly Phase 2
- Acute cholecystitis Phase 3
- [Acute coronary syndrome](https://trialight.com/data/condition/acute-coronary-syndrome-3d7c2c1f-86ca-5a25-913a-6f9a7e95f989.md) Phase 2
- Acute kidney injury Phase 3
- Acute kidney tubular necrosis Phase 1
- Acute liver failure Phase 2
- [Acute lung injury](https://trialight.com/data/condition/acute-lung-injury-fb11c447-d7f6-5c24-8fb9-764bbaaabced.md) Phase 3
- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 2
- [Acute myocardial infarction](https://trialight.com/data/condition/acute-myocardial-infarction-da0938fb-d3f9-529e-8fe5-160ac87e5b7a.md) Phase 3
- Acute pancreatitis Phase 3
- [Acute respiratory distress syndrome](https://trialight.com/data/condition/acute-respiratory-distress-syndrome-8dc4b74c-8356-5dfd-bfa3-258d9d1e44ab.md) Phase 2
- Adiposis dolorosa Phase 2
- [Adult acute respiratory distress syndrome](https://trialight.com/data/condition/adult-acute-respiratory-distress-syndrome-52101d99-65d3-54cf-b5da-f664febc6a7e.md) Phase 2
- [Age-related macular degeneration](https://trialight.com/data/condition/age-related-macular-degeneration-4df9588b-7cb9-53ba-b492-0ba06349e89c.md) Phase 2
- AIDS Phase 1
- [Alcohol dependence](https://trialight.com/data/condition/alcohol-dependence-d26b3f0d-c0fb-5084-9194-e963df0e9179.md) Phase 3

### Other linked conditions (4)

- Acute bronchiolitis
- [Endophthalmitis](https://trialight.com/data/condition/endophthalmitis-38a5b8a5-32e3-5243-974c-067bfa1c05b1.md)
- Gastroesophageal reflux disease
- Lipoma

---

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