> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/silmitasertib-6e58fcc4-d42d-493a-ae85-003b29c7ea52
> Record changed: 2026-10-13

# Silmitasertib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

**Drug name**

Silmitasertib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

**Molecular weight**

349.78

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

**Structure (SMILES)**

O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

### Other names (24)

- benzo c 2 6 naphthyridine 8 carboxylic acid 5 3 chlorophenyl amino
- BENZO(C)-2,6-NAPHTHYRIDINE-8-CARBOXYLIC ACID, 5-((3-CHLOROPHENYL)AMINO)-
- cx 4945
- CX 4945
- cx 4945 free acid
- cx 4945 silmitasertib
- Cx-4945
- CX-4945
- CX-4945 (Influenza virus domain)
- CX-4945 (SARS-CoV-2 domain)
- CX-4945 (SILMITASERTIB)
- Cx-4945 free acid
- CX-4945 FREE ACID
- cx4945
- CX4945
- silmitasertib
- Silmitasertib
- SILMITASERTIB
- SILMITASERTIB (CX-4945)
- silmitasertib \[INN\]
- Silmitasertib \[WHO-DD\]
- silmitasertib cx 4945
- silmitasertib inn
- silmitasertib who dd

## Identifiers

**CAS registry numbers**

- 1009820-21-6

**ChEMBL ID**

CHEMBL1230165

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

**InChIKey**

MUOKSQABCJCOPU-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1230165)

**PubChem compound IDs**

- 24748573

**FDA ingredient codes (UNII)**

- C6RWP0N0L2

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

2

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

silmitasertib

**Type**

Synthetic organic

**Drug name stem**

\-sertib

### Mechanisms of action (6)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
death associated protein kinase 3

**Gene symbol**  
DAPK3

**Protein identifier**  
O43293

**Median affinity**

7.77

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Pim-1 proto-oncogene, serine/threonine kinase

**Gene symbol**  
PIM1

**Protein identifier**  
P11309

**Median affinity**

6.67

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
casein kinase 2, alpha prime polypeptide subunit

**Gene symbol**  
CSNK2A2

**Protein identifier**  
P19784

**Median affinity**  
9

**Affinity units**  
pIC50

**Primary target**  
Yes
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
casein kinase 2, alpha 1 polypeptide subunit

**Gene symbol**  
CSNK2A1

**Protein identifier**  
P68400

**Median affinity**  
9

**Affinity units**  
pIC50

**Primary target**  
Yes
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
homeodomain interacting protein kinase 3

**Gene symbol**  
HIPK3

**Protein identifier**  
Q9H422

**Median affinity**

7.35

**Affinity units**  
pIC50
- **Mechanism**  
Casein kinase II alpha inhibitor

**Action type**  
Inhibitor

**Target**  
Casein kinase II subunit alpha

**Protein identifier**  
P68400

### Open Targets mechanisms

- **Mechanism**  
Casein kinase II alpha inhibitor

**Action type**  
Inhibitor

**Target**  
Casein kinase II subunit alpha

### Investigated indications (5)

- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Medulloblastoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0002939

**Subject identifier**  
D008527
- **Condition**  
Carcinoma, Basal Cell

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004193

**Subject identifier**  
D002280
- **Condition**  
Cholangiocarcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005221

**Subject identifier**  
D018281
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (10)

- **Condition identifier**  
EFO\_0001378

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0002939
- **Condition identifier**  
EFO\_0004193

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005221
- **Condition identifier**  
EFO\_0007224

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0015564

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0019087

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0020804

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0100096

**Highest recorded phase**  
2

### Trial references (7)

- NCT01199718  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01199718)
- NCT02128282  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02128282)
- NCT03897036  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03897036)
- NCT03904862  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03904862)
- NCT04663737  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04663737)
- NCT04668209  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04668209)
- NCT05817708  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05817708)

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

2

**Polar surface area**

75.11

**Calculated partition coefficient (ALogP)**

4.88

**Calculated partition coefficient (XLogP)**

4.4

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

25

**Molecular formula**

C19H12ClN3O2

**Monoisotopic mass**

349.0618043

**Natural product**

No

## Evidence counts

**Recorded assays**

2,298

**Active assays**

439

### Active assay types (3)

- Confirmatory
- Other
- Screening

## Biological measurements

### Observed measurements

#### Solubility

**Median**

277,100

**Mean**

277,100

**Minimum**

277,100

**Maximum**

277,100

**Unit**

nM

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

#### Oral bioavailability

**Median**

48

**Mean**

39.6667

**Minimum**

20

**Maximum**

51

**Unit**

%

**Assays**

3

**Standard deviation**

17.0978

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (163)

- [A Clinical Trial to Evaluate the Immunogenicity and Safety of Group ACYW135 Meningococcal Conjugate Vaccine (CRM197) in Adults Aged 18 to 55 Years](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-the-immunogenicity-and-safety-b02dd49b-1c3f-4a50-9b06-8273912d6fc8.md)
- A Clinical Trial to Evaluate the Reversibility of Abacavir/Lamivudine/Dolutegravir CNS-Related Neurotoxicity After Switching to Tenofovir/Alafenamide/Emtricitabine/Darunavir/Cobicistat (TAF/FTC/DRV/c)
- A Drug Interaction Study of Cilnidipine and Valsartan
- A Phase 1/2 Study of CAN04 in Combination With Different Chemotherapy Regimens in Subjects With Advanced Solid Tumors
- A Phase I Study to Assess the Pharmacokinetics of GSK2798745 Tablets
- A Phase I, Randomized, Modified Single-blind, Active-controlled (Infants Only), Four-stage, Step-down, Comparative, Multi-center Study
- A Safety and Immunogenicity Study of 3 Doses of Opal Immunotherapy in HIV Infected People
- A Sourcing Study to Collect Human Blood Samples From Healthy Adults
- A Study in Healthy Men to Test if Taking Different Formulations of BI 1358894 With or Without Food Influences the Amount of BI 1358894 in the Blood
- A Study of a Quadrivalent Meningococcal Tetanus Protein Conjugate Vaccine in Infants and Toddlers
- A Study of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Evaluated as a Fixed Dose Combination Regimen in Participants Switching From an Integrase Inhibitor Who Have Experienced Rapid Weight Gain
- A Study of LY3202626 in Healthy Participants and Participants With Alzheimer's Disease
- A Study of Silmitasertib (CX-4945) in Healthy Subject
- A Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Fixed Dose Combination (FDC) Versus a Regimen Consisting of Darunavir/Cobicistat FDC With Emtricitabine/Tenofovir Disoproxil Fumarate FDC in Treatment-naive HIV Type 1 Infected Subjects
- A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella and Typhoid Fever
- A Study to Evaluate the Safety and Immunogenicity of a Candidate Ebola Vaccine in Children
- A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV Treatments
- Adherence With Iron Sprinkles Among High-Risk Infants
- Adjunctive Supplementation of Antioxidants (Vitamins E + C) Plus Omega-3 Fatty Acids
- An Italian Observation of Antiretroviral Treatment in Participants Taking Darunavir/ Cobicistat Plus Emtricitabine and Tenofovir Alafenamide Fumarate

### In development for (5)

- [Basal cell carcinoma](https://trialight.com/data/condition/basal-cell-carcinoma-c09b4859-3642-5fab-89f0-8eede3ad7a6e.md) Phase 1
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 1
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 2
- Medulloblastoma Phase 1
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 1

### Targets (1)

- [CSNK2A1](https://trialight.com/data/target/csnk2a1-3f512e39-8c51-58d9-8684-59bcb575d9a0.md) Casein kinase II alpha inhibitor

---

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