> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/shr-4640-284efbb4-c1fa-416d-b7f3-b7d0df31f0aa
> Record changed: 2026-10-13

# SHR-4640

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

**Drug name**

SHR-4640

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

**Molecular weight**

338.23

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

**Structure (SMILES)**

O=C(O)C1(Sc2ccnc3ccc(Br)cc23)CCC1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

### Other names (15)

- 1 6 bromo 4 quinolinyl thio cyclobutanecarboxylic acid
- 1-((6-BROMO-4-QUINOLINYL)THIO)CYCLOBUTANECARBOXYLIC ACID
- ruzinurad
- Ruzinurad
- ruzinurad \[INN\]
- Ruzinurad \[WHO-DD\]
- ruzinurad inn
- ruzinurad who dd
- shr 4640
- Shr-4640
- SHR-4640
- shr4640
- Shr4640
- SHR4640
- SHR4640 tablet

## Identifiers

**CAS registry numbers**

- 1638327-48-6

**ChEMBL ID**

CHEMBL3746329

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

**InChIKey**

QGBWIYLNOBYNDL-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3746329)

**PubChem compound IDs**

- 86294127

**FDA ingredient codes (UNII)**

- UP8J9CA76I

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Mechanisms of action

- **Mechanism**  
Solute carrier family 22 member 12 inhibitor

**Action type**  
Inhibitor

**Target**  
Solute carrier family 22 member 12

**Protein identifier**  
Q96S37

### Open Targets mechanisms

- **Mechanism**  
Solute carrier family 22 member 12 inhibitor

**Action type**  
Inhibitor

**Target**  
Solute carrier family 22 member 12

### Investigated indications (3)

- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Gout

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004274

**Subject identifier**  
D006073
- **Condition**  
Hyperuricemia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0009104

**Subject identifier**  
D033461

### Open Targets indications (4)

- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0004274

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0009104

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005393

**Highest recorded phase**  
3

### Trial references (10)

- NCT03015948  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03015948)
- NCT03131583  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03131583)
- NCT04052932  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04052932)
- NCT04956432  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04956432)
- NCT03185793  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03185793)
- NCT04157959  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04157959)
- NCT04180982  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04180982)
- NCT05954169  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05954169)
- NCT06168929  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06168929)
- NCT04305392  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04305392)

## Chemical properties

**Hydrogen bond acceptors**

3

**Hydrogen bond donors**

1

**Polar surface area**

50.19

**Calculated partition coefficient (ALogP)**

4.1

**Calculated partition coefficient (XLogP)**

3.7

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

3

**Heavy atoms**

19

**Molecular formula**

C14H12BrNO2S

**Monoisotopic mass**

336.97721

**Natural product**

No

## Evidence counts

**Recorded assays**

54

**Active assays**

5

### Active assay types

- Confirmatory

## Biological measurements

These details could not be displayed.

## Related records

### Trials (20)

- A Multicentre, Randomized, Double-blind, Allopurinol Controlled Study to Evaluate the Efficacy and Safety of SHR4640 in Subjects With Gout
- A Safety and Efficacy Study of SHR4640 and Febuxostat in Subjects With Hyperuricemia
- A Single Dose Study of SHR4640 in Healthy Male Volunteers
- A Study of Evaluating the Efficacy and Safety of SHR4640 in Subjects With Gout
- Bioequivalence Study of 2 Sizes of SHR4640 Tablets Orally in Healthy Subjects
- Clinical Study of SHR4640 Tablets Combined With Febuxostat Tablets in the Treatment of Primary Gout and Hyperuricemia
- Dose-finding and Safety Study of SHR4640 in Subjects With Hyperuricemia
- Drug Interaction Between SHR4640 Tablets and Furosemide Tablets in Healthy Volunteers (Single Center, Single Arm, Open, Self-control)
- Multiple Dose Study of SHR4640 in Healthy Subjects
- Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level
- Pharmacokinetic/Pharmacokinetic and Safety Studies of SHR4640 in Subjects With Moderate Renal Insufficiency and Healthy Subjects
- Pharmacokinetics, Pharmacodynamics and Safety of SHR4640 in Patients With Hepatic Impairment
- PK Effects of SHR4640 on Repaglinide and Midazolam, and the Impact of SHR4640 on QT Interval
- Single Dose Study of SHR4640 in Healthy Subjects
- Study on the Bioavailability of Three Different Prescription Processes of SHR4640 Tablets in Healthy Volunteers
- Study on the Food Effects of Oral SHR4640 Tablets in Healthy Volunteers
- Study to Evaluate the Mass Balance and Biotransformation of \[14C\]SHR4640 in Chinese Healthy Adult Male Volunteers.
- The Drug-Drug Interaction of SHR4640 and Febuxostat in Patients With Hyperuricemia
- The Drug-Drug Interaction of SHR4640, Febuxostat and Colchicine in Patients With Gout
- [The Efficacy and Safety of SHR4640 Tablet Combined With 40 mg Febuxostat Tablets in the Treatment of Primary Gout and Hyperuricemia](https://trialight.com/data/trial/the-efficacy-and-safety-of-shr4640-tablet-combined-with-40-9280bba2-7d68-43f7-b356-4656a1a6c54a.md)

### In development for (2)

- [Gout](https://trialight.com/data/condition/gout-b61aaf55-4a3b-56d9-966a-ca77100d2fc5.md) Phase 3
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1

### Targets (1)

- [SLC22A12](https://trialight.com/data/target/slc22a12-6d9b9159-a283-5eb9-8699-67b6a8275d07.md) Solute carrier family 22 member 12 inhibitor

---

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