> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/sevabertinib-c397ddd0-c220-43e7-aeab-d862ae5fc9fe > Record changed: 2026-10-13 # Sevabertinib Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) **Drug name** Sevabertinib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) **Molecular weight** 484.94 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) **Structure (SMILES)** COc1c(Cl)cccc1Nc1c(-c2ccncc2OC\[C@@H\]2COCCO2)\[nH\]c2c1C(=O)NCC2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) ### Other names (15) - bay 2927088 - BAY-2927088 - bay2927088 - BAY2927088 - sevabertinib - Sevabertinib - Sevabertinib (BAY 2927088) - sevabertinib \[INN\] - SEVABERTINIB \[USAN\] - Sevabertinib \[WHO-DD\] - sevabertinib anhydrous - Sevabertinib anhydrous - sevabertinib inn - sevabertinib usan - sevabertinib who dd ## Identifiers **ATC classification codes** - L01EH06 Sources for recorded values Source: [mor.nlm.nih.gov](https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=2728187) **CAS registry numbers** - 2521285-05-0 **ChEMBL ID** CHEMBL6068074 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) **InChIKey** VYQVHWNNPKOJEA-AWEZNQCLSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068074) **PubChem compound IDs** - 155234713 **RxNorm IDs (RxCUI)** - 2728187 **FDA ingredient codes (UNII)** - 2A7VPM5RWH ## Regulatory information ### Other regulatory facts **Patents** 1 **Designations** 6 **Earliest recorded loss of exclusivity** 10 Oct 2035 **First in class** No **Fast track** No **Breakthrough designation** Yes **Orphan designation** No **Priority review** Yes **Orphan exclusivity** No **Accelerated approval** Yes ## Pharmacology ### Drug classification **Pharmacology name** sevabertinib **Type** Synthetic organic **Drug name stem** \-tinib **Approval recorded by Guide to Pharmacology** Yes ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (3) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 3 ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 3 **Polar surface area** 106.73 **Calculated partition coefficient (ALogP)** 3.56 **Calculated partition coefficient (XLogP)** 2.9 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 7 **Heavy atoms** 34 **Molecular formula** C24H25ClN4O5 **Monoisotopic mass** 484.1513476 **Natural product** No ## National Drug Codes - 50419-397 ## Related records ### Trials (11) - A Study Evaluating How Moderate Liver Impairment Affects the Absorption, Distribution, Metabolism, and Elimination of Sevabertinib After a Single Oral Dose - A Study to Learn About How BAY2927088 Affects the Level of Dabigatran or Rosuvastatin in the Blood When These Drugs Are Taken Together in Healthy Participants - A Study to Learn About How BAY2927088 Affects the Level of Midazolam in the Blood When Both Drugs Are Taken Together in Healthy Participants - A Study to Learn About How Food and Esomeprazole Affect the Level of BAY2927088 in the Blood When Taken Together in Healthy Participants - A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participants - A Study to Learn How BAY2927088 is Taken up and Handled by the Body in Healthy Male Participants - A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) - A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) - Expanded Access to Provide Sevabertinib (BAY 2927088) for the Treatment of Locally Advanced or Metastatic NSCLC With HER2 Mutation - [First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)](https://trialight.com/data/trial/first-in-human-study-of-bay2927088-in-participants-who-have-2ddc3ef6-3560-4058-a6b4-1a93e2d86ea7.md) - Phase 1 Study in Healthy Adults to See How Sevabertinib Changes Metformin Levels in the Body ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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