> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/setidegrasib-947fc0f8-4ff5-4a70-8577-baf5799fb8ef > Record changed: 2026-10-13 # Setidegrasib Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068173) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068173) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068173) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068173) **Drug name** Setidegrasib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068173) **Structure (SMILES)** c1n\[nH\]c2cc(c(C)c(c21)-c3c(OCc4ccc(cc4)-c5cn(\[C@H\](C(=O)N6C\[C@@H\](C\[C@H\]6C(N\[C@H\](c7ccc(-c8c(ncs8)C)cc7)CO)=O)O)C(C)C)nn5)c9c(c(N%10\[C@@\]%11(CN\[C@@\](\[H\])(C%11)C%10)\[H\])nc(n9)OC%12CCOCC%12)cc3C%13CC%13)F Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/3NQ4ME292X) ### Other names (8) - 2 pyrrolidinecarboxamide 1 2s 2 4 4 6 cyclopropyl 4 1s 4s 2 5 diazabicyclo 2 2 1 hept 2 yl 7 6 fluoro 5 methyl 1h indazol 4 yl 2 tetrahydro 2h pyran 4 yl oxy 8 quinazolinyl oxy methyl phenyl 1h 1 2 3 triazol 1 yl 3 methyl 1 oxobutyl 4 hydroxy n 1r 2 hydroxy 1 4 4 methyl 5 thiazolyl phenyl ethyl 2s 4r - 2-Pyrrolidinecarboxamide, 1-\[(2S)-2-\[4-\[4-\[\[\[6-cyclopropyl-4-(1S,4S)-2,5-diazabicyclo\[2.2.1\]hept-2-yl-7-(6-fluoro-5-methyl-1H-indazol-4-yl)-2-\[(tetrahydro-2H-pyran-4-yl)oxy\]-8-quinazolinyl\]oxy\]methyl\]phenyl\]-1H-1,2,3-triazol-1-yl\]-3-methyl-1-oxobutyl\]-4-hydroxy-N-\[(1R)-2-hydroxy-1-\[4-(4-methyl-5-thiazolyl)phenyl\]ethyl\]-, (2S,4R)- - setidegrasib - Setidegrasib - setidegrasib \[INN\] - Setidegrasib \[WHO-DD\] - setidegrasib inn - setidegrasib who dd ## Identifiers **CAS registry numbers** - 2821793-99-9 **ChEMBL ID** CHEMBL6068173 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068173) **InChIKey** XXWMEQMGQNHRAF-WFJRNIGCSA-N Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/3NQ4ME292X) **PubChem compound IDs** - 164875418 **FDA ingredient codes (UNII)** - 3NQ4ME292X ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-rasib ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (6) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005184 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006047 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 3 ## Chemical properties **Calculated partition coefficient (XLogP)** 7.7 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Heavy atoms** 81 **Monoisotopic mass** 1116.48039179 **Natural product** No ## Related records ### Trials (4) - [A Study of ASP3082 in Adults With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-asp3082-in-adults-with-advanced-solid-tumors-59ee7502-0056-4353-8442-cb774f9d25f5.md) - A Study to Compare Setidegrasib (ASP3082) With Docetaxel, in People With Non-small Cell Lung Cancer With a KRAS G12D Mutation - A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer - A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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