> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/senaparib-5d728ab4-660f-428a-b890-bbc768e824c5
> Record changed: 2026-10-13

# Senaparib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

**Drug name**

Senaparib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

**Molecular weight**

478.46

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

**Structure (SMILES)**

O=C(c1cc(Cn2c(=O)\[nH\]c(=O)c3c(F)cccc32)ccc1F)N1CCN(c2ncccn2)CC1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

### Other names (18)

- imp 4297
- IMP-4297
- imp4297
- Imp4297
- IMP4297
- IMP4297 100 mg
- IMP4297 40 mg
- IMP4297(10mg)
- IMP4297(20mg)
- IMP4297(senaparib)
- senaparib
- Senaparib
- senaparib \[INN\]
- Senaparib \[WHO-DD\]
- Senaparib capsules(10mg)
- Senaparib capsules(20mg)
- senaparib inn
- senaparib who dd

## Identifiers

**CAS registry numbers**

- 1401682-78-7

**ChEMBL ID**

CHEMBL4802152

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

**InChIKey**

VBTUJTGLLREMNW-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4802152)

**PubChem compound IDs**

- 68389008

**FDA ingredient codes (UNII)**

- MNZ4OP95CF

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

senaparib

**Type**

Synthetic organic

**Drug name stem**

\-parib

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (2)

- **Mechanism**  
Poly \[ADP-ribose\] polymerase 2 inhibitor

**Action type**  
Inhibitor

**Target**  
Poly \[ADP-ribose\] polymerase 2

**Protein identifier**  
Q9UGN5
- **Mechanism**  
Poly \[ADP-ribose\] polymerase-1 inhibitor

**Action type**  
Inhibitor

**Target**  
Poly \[ADP-ribose\] polymerase 1

**Protein identifier**  
P09874

### Open Targets mechanisms (2)

- **Mechanism**  
Poly \[ADP-ribose\] polymerase 2 inhibitor

**Action type**  
Inhibitor

**Target**  
Poly \[ADP-ribose\] polymerase 2
- **Mechanism**  
Poly \[ADP-ribose\] polymerase-1 inhibitor

**Action type**  
Inhibitor

**Target**  
Poly \[ADP-ribose\] polymerase 1

### Investigated indications (5)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008170

**Subject identifier**  
D010051
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129

### Open Targets indications (11)

- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0000548

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006335

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0015686

**Highest recorded phase**  
3

### Trial references (9)

- NCT03507543  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03507543)
- NCT04089189  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04089189)
- NCT04057729  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04057729)
- NCT04351165  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04351165)
- NCT04584515  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04584515)
- NCT05109832  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05109832)
- NCT05390944  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05390944)
- NCT05391048  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05391048)
- NCT05262842  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05262842)

## Chemical properties

**Hydrogen bond acceptors**

7

**Hydrogen bond donors**

1

**Polar surface area**

104.19

**Calculated partition coefficient (ALogP)**

1.77

**Calculated partition coefficient (XLogP)**

2

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

4

**Heavy atoms**

35

**Molecular formula**

C24H20F2N6O3

**Monoisotopic mass**

478.15649485

**Natural product**

No

## Related records

### Trials (17)

- A Bioequivalence Study to Compare Senaparib Manufactured at 2 Sites in Healthy Subjects in Fasting State
- A Prospective Observational Study of Senaparib in the Treatment of Epithelial Ovarian Cancer
- A Study of Absorption-Distribution-Metabolism-Excretion (ADME) of \[14C\]IMP4297 to China Healthy Male Subjects
- A Study of IMP4297 in Patients With Advanced Solid Tumors
- An BE Study to Compare 10mg & 20mg of IMP4297 Capsules in Healthy Chinese Subjects Under Fasting Condition
- An BE Study to Compare 10mg & 20mg of IMP4297 Capsules in Healthy Chinese Subjects Under Fed Condition
- An Bioequivalence Study to Compare 10mg & 20mg of Senaparib Capsules in Healthy Chinese Subjects Under Fasting Condition
- BA Study of IMP4297 (20mg vs 10mg) in Healthy Male Subjects
- Combination Therapy of Senaparib and Bevacizumab for First-line Maintenance Therapy in Newly Diagnosed Advanced Homologous Recombination Proficient Ovarian Cancer Based on Exosome Protein Marker
- IMP4297 DDI (Drug-Drug Interaction)Trial in Healthy Male Volunteers
- IMP4297 Food Effect Trial in Healthy Volunteers
- IMP4297 in Combination With Temozolomide in Patients With Advanced Solid Tumors and Small Cell Lung Cancer
- JS001+IMP4297 in Patients With Advanced Cancer
- [Senaparib in mCRPC Patients With Homologous Recombination Repair Gene Alterations After Docetaxel Treatment](https://trialight.com/data/trial/senaparib-in-mcrpc-patients-with-homologous-recombination-139ba385-1e8f-41a7-99f2-96743e69280e.md)
- Study of IMP4297 in Patients With BRCA1/2 Mutation Ovarian Cancer
- Study of Senaparib in Combination With Temozolomide in ARID1A Mutation Associated Ovarian Cancer
- The Safety and Pharmacokinetics of IMP4297 in Patients With Advanced Solid Tumors

### In development for (5)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 1
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- Neoplasm Phase 1
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) Phase 2
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 1

### Targets (2)

- [PARP1](https://trialight.com/data/target/parp1-78c558f2-1477-56b9-9f9f-c1e925a07421.md) Poly \[ADP-ribose\] polymerase-1 inhibitor
- [PARP2](https://trialight.com/data/target/parp2-2551f72f-f11f-5c9e-9253-3f01dfbad379.md) Poly \[ADP-ribose\] polymerase 2 inhibitor

---

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