> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/sasanlimab-831ba76e-bff4-42a3-b3bd-06b8a73e1d91
> Record changed: 2026-10-13

# Sasanlimab

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298191)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298191)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298191)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298191)

**Drug name**

Sasanlimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298191)

### Other names (14)

- anti pd 1 checkpoint inhibitor pf 06801591
- ANTI-PD-1 CHECKPOINT INHIBITOR PF-06801591
- pf 06801591
- PF-06801591
- rn 888
- RN-888
- sasanlimab
- Sasanlimab
- sasanlimab \[INN\]
- SASANLIMAB \[USAN\]
- Sasanlimab \[WHO-DD\]
- sasanlimab inn
- sasanlimab usan
- sasanlimab who dd

## Identifiers

**ATC classification codes**

- L01FF

**CAS registry numbers**

- 2206792-50-7

**ChEMBL ID**

CHEMBL4298191

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298191)

**FDA ingredient codes (UNII)**

- LZZ0IC2EWP

## Regulatory information

### European Union

**Status**

application\_withdrawn

**Approved indications**

Treatment of bladder cancer in adults indicated for the treatment of adult indicated for treatement of bladder cancer.

**Product number**

EMEA/H/C/006641

**Authorisation holder**

Pfizer Europe MA EEIG

**Priority medicines scheme**

No

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

No

**Additional monitoring**

No

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Urinary Bladder Neoplasms

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/zumrad)

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-mab

### Mechanisms of action

- **Mechanism**  
Programmed cell death protein 1 antagonist

**Action type**  
Antagonist

**Target**  
Programmed cell death protein 1

**Protein identifier**  
Q15116

### Open Targets mechanisms

- **Mechanism**  
Programmed cell death protein 1 antagonist

**Action type**  
Antagonist

**Target**  
Programmed cell death protein 1

### Investigated indications (6)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000673

**Subject identifier**  
D011471
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0008528

**Subject identifier**  
D001749
- **Condition**  
Neoplasm Metastasis

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0009708

**Subject identifier**  
D009362
- **Condition**  
Urinary Bladder Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0001187

**Subject identifier**  
D001749

### Open Targets indications (37)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0003060
- **Condition identifier**  
EFO\_0005952

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0008528

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0009708

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001187

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002367

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004647

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004986

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004987
- **Condition identifier**  
MONDO\_0004992

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005005

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005062

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005086

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005089

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005097

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005105

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005140

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005611

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005627

**Highest recorded phase**  
1

And 12 more, listed on the interactive page.

### Trial references (7)

- NCT02616185  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02616185)
- NCT04165317  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04165317)
- NCT05259397  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05259397)
- NCT04458259  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04458259)
- NCT04585815  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04585815)
- NCT06218069  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06218069)
- NCT05241340  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05241340)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Heavy chain: anti-VEGFA

**Type**  
Protein

**Sequence**  
QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYWINWVRQAPGQGLEWMGNIYPGSSLTNYNEKFKNRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARLSTGTFAYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-294 $ Asn-294''''
- **Component**  
Light chain: anti-VEGFA

**Type**  
Protein

**Sequence**  
DIVMTQSPDSLAVSLGERATINCKSSQSLWDSGNQKNFLTWYQQKPGQPPKLLIYWTSYRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNDYFYPHTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-94' $ 23'''-94''' $ 131-220' $ 131''-220''' $ 140'-200' $ 140'''-200''' $ 144-200 $ 144''-200'' $ 223-223'' $ 226-226'' $ 258-318 $ 258''-318'' $ 364-422 $ 364''-422''
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-294 $ Asn-294''

## Related records

### Trials (25)

- A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies
- A Dose Escalation Study Of PF-06801591 In Melanoma, Head And Neck Cancer (SCCHN), Ovarian, Sarcoma, Non-Small Cell Lung Cancer, Urothelial Carcinoma or Other Solid Tumors
- A Phase 1 Study To Evaluate Escalating Doses Of A Vaccine-Based Immunotherapy Regimen For Prostate Cancer (PrCa VBIR)
- A Safety Study of SEA-TGT (SGN-TGT) in Advanced Cancer
- A Study in Advanced/Metastatic Solid Tumors With the Study Medicine (PF-07329640) When Given Alone or In Combination
- A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors
- A Study of Sasanlimab in People With Non-muscle Invasive Bladder Cancer
- A Study of Sasanlimab, Palbociclib and Axitinib in Metastatic Renal Cell Carcinoma
- A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With Cancer When Taken Alone or With Other Anti-cancer Medicines.
- A Study to Learn About PF-07921585 Alone or With Other Anti-cancer Medicines in People With Cancer
- A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers
- A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.
- A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.
- [A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer](https://trialight.com/data/trial/a-study-to-learn-about-the-study-medicine-pf-08052667-in-f1456318-d5a1-4f48-99b2-e5f049cf58eb.md)
- Immuno-pet IMaging ResPonses AdministeRed Immune CheckpoiNt InhibiTor
- Ketohexokinase Inhibition in Hereditary Fructose Intolerance
- Neoadjuvant Sasanlimab With Radiation as an in Situ Vaccine for Cisplatin-ineligible Muscle Invasive Bladder Cancer
- Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Papillary Renal Cell Carcinoma (pRCC)
- PF-07225570 Alone or in Combination With an Anti-PD-1 Antibody in Recurrent Non-muscle Invasive Bladder Cancer (NMIBC)
- PF-07265028 As Single Agent And In Combination With Sasanlimab in Advanced or Metastatic Solid Tumors

### In development for (6)

- Neoplasm Phase 1
- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 1
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2
- [Prostate adenocarcinoma](https://trialight.com/data/condition/prostate-adenocarcinoma-84e3e3af-1ae1-5760-8157-8d9fc0cff608.md) Phase 1
- Urinary bladder cancer Phase 3
- [Urothelial carcinoma](https://trialight.com/data/condition/urothelial-carcinoma-b2aa266d-2d5f-5e5d-a0de-62274f2dc094.md) Phase 3

### Targets (1)

- [PDCD1](https://trialight.com/data/target/pdcd1-a7b9a076-9fdd-55c9-9ce8-e558e5c7503f.md) Programmed cell death protein 1 antagonist

---

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