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Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/saruplase-b321be62-b17c-4e99-be93-cf42b78a820f > Record changed: 2026-10-13 # Saruplase Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108129) Drug type Enzyme Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108129) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108129) ## Names and chemistry **Drug type** Enzyme Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108129) **Drug name** Saruplase Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108129) ### Other names (27) - cg 4509 - CG 4509 - CG-4509 - cg4509 - Cg4509 - KINASE (ENZYME-ACTIVATING), PROURO- (HUMAN CLONE PUK33 REDUCED) - KINASE (ENZYME-ACTIVATING), PROURO- (HUMAN CLONE PUK4/PUK18 PROTEIN MOIETY REDUCED) - kinase enzyme activating prouro human clone puk33 reduced - kinase enzyme activating prouro human clone puk4 puk18 protein moiety reduced - plasminogen activator pro human liver urokinase type protein moiety reduced - PLASMINOGEN ACTIVATOR, PRO- (HUMAN LIVER UROKINASE-TYPE PROTEIN MOIETY REDUCED) - PROUROKINASE (ENZYME ACTIVATING) (HUMAN CLONE PUK4/PUK18), NONGLYCOSYLATED - prourokinase enzyme activating human clone puk4 puk18 nonglycosylated - saruplasa - Saruplasa - saruplase - Saruplase - saruplase \[INN\] - SARUPLASE \[MI\] - Saruplase \[WHO-DD\] - saruplase inn - saruplase mi - saruplase who dd - scupa - Scupa And 2 more, listed on the interactive page. ## Identifiers **ATC classification codes** - B01AD08 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108129) **CAS registry numbers** - 99149-95-8 **ChEMBL ID** CHEMBL2108129 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2108129) **FDA ingredient codes (UNII)** - U5NH2JV64T ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-ase ### Investigated indications - **Condition** Thrombosis **Highest recorded phase** 4 **Condition identifier** HP:0004419 **Subject identifier** D013927 ### Open Targets indications (3) - **Condition identifier** HP\_0004419 - **Condition identifier** HP\_0004419 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0000831 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (19) - A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer - A Second-generation AI Based Therapeutic Regimen in Patients With Gaucher Disease Treated With Enzyme Replacement Therapy. - A Study to Assess the Safety and Tolerability of Lucerastat in Subjects With Fabry Disease - A Study to Describe the Experience of Both Patients and Their Clinicians in the Treatment of Fabry Disease With Enzyme Replacement Therapy. - ALDH Enzyme in CRF With Advanced GI Cancer - An Efficacy and Safety Study of AVR-RD-02 Compared to Enzyme Replacement Therapy for Treatment of Gaucher Disease Type 3 - Clinical Evaluation of Arthrocentesis, Combination of Platelet-Rich Plasma and Cyclooxygenase Enzyme-2 Inhibitor in Treatment of Temporo-Mandibular Joint Anterior Displacement - Effect of Digestive Enzymes as Add on Therapy on Patients With Functional Dyspepsia. - Fabry: Renal Function During Long-term ERT by 51Cr-EDTA Clearance - Follow-up of Myocardial T1 Relaxation Time in Patients With Anderson Fabry Disease - In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme - Intestinal Microbiota Composition in Patients With Chronic Pancreatitis and Pancreatic Exocrine Insufficiency - Ophthalmic Findings During 10-year Enzyme Substitution of Danish Fabry Patients. - Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma - [Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes](https://trialight.com/data/trial/phase-1-1b-study-of-tlc-6740-in-healthy-subjects-and-de500b60-a3de-4cb1-9005-a51fdfe3d3d2.md) - Primaquine for Vivax Malaria in G6PD Intermediate and Deficient Cases. - Search for Serum/Plasma Biomarkers in Pompe's Disease - The Effect of Enzyme Replacement Therapy in Mucopolysaccharidosis - Trial of Enzastaurin and Bevacizumab in Participants With Recurrent Malignant Gliomas ### Approved for (1) - [Thrombotic disease](https://trialight.com/data/condition/thrombotic-disease-3f54ef10-d2ed-524f-a020-8ecb2eb62a52.md) --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. 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