> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/saruparib-fab16202-4886-4dbb-8931-832b768b97e4
> Record changed: 2026-10-13

# Saruparib

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

**Drug name**

Saruparib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

**Molecular weight**

406.49

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

**Structure (SMILES)**

CCc1cc2ncc(CN3CCN(c4ccc(C(=O)NC)nc4)CC3)cc2\[nH\]c1=O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

### Other names (17)

- azd 5305
- Azd 5305
- AZD 5305
- Azd-5305
- AZD-5305
- azd5305
- AZD5305
- saruparib
- Saruparib
- SARUPARIB
- Saruparib (AZD5305)
- saruparib \[INN\]
- SARUPARIB \[USAN\]
- Saruparib \[WHO-DD\]
- saruparib inn
- saruparib usan
- saruparib who dd

## Identifiers

**CAS registry numbers**

- 2589531-76-8

**ChEMBL ID**

CHEMBL5095220

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

**InChIKey**

WQAVGRAETZEADU-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095220)

**PubChem compound IDs**

- 155586901

**FDA ingredient codes (UNII)**

- 16MZ1V3RBT

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

saruparib

**Type**

Synthetic organic

**Drug name stem**

\-parib

### Mechanisms of action (2)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
poly(ADP-ribose) polymerase 1

**Gene symbol**  
PARP1

**Protein identifier**  
P09874

**Median affinity**

8.4

**Affinity units**  
pIC50

**Primary target**  
Yes
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
poly(ADP-ribose) polymerase 2

**Gene symbol**  
PARP2

**Protein identifier**  
Q9UGN5

**Median affinity**

5.82

**Affinity units**  
pIC50

### Investigated indications (6)

- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000196

**Subject identifier**  
D011471
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129

### Open Targets indications (12)

- **Condition identifier**  
EFO\_0000196
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005140

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0007254

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0008433

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0015686

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018364

**Highest recorded phase**  
1

### Trial references (6)

- NCT04550104  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04550104)
- NCT05367440  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05367440)
- NCT05573724  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05573724)
- NCT05938270  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05938270)
- NCT06120491  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06120491)
- NCT06380751  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06380751)

## Chemical properties

**Hydrogen bond acceptors**

6

**Hydrogen bond donors**

2

**Polar surface area**

94.22

**Calculated partition coefficient (ALogP)**

1.56

**Calculated partition coefficient (XLogP)**

1.1

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

5

**Heavy atoms**

30

**Molecular formula**

C22H26N6O2

**Monoisotopic mass**

406.21172409

**Natural product**

No

## Evidence counts

**Recorded assays**

227

**Active assays**

32

### Active assay types

- Confirmatory

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

1.9

**Mean**

1.9

**Minimum**

1.9

**Maximum**

1.9

**Unit**

unitless

**Assays**

2

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

#### Solubility

**Median**

50,000

**Mean**

50,000

**Minimum**

50,000

**Maximum**

50,000

**Unit**

nM

**Assays**

2

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

#### Oral bioavailability

**Median**

99.5

**Mean**

101

**Minimum**

73

**Maximum**

132

**Unit**

%

**Assays**

4

**Standard deviation**

30.3425

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

#### Plasma protein binding

**Median**

0.02

**Mean**

0.02

**Minimum**

0.02

**Maximum**

0.02

**Unit**

fraction unbound

**Assays**

2

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Fu

## Related records

### Trials (18)

- A Master Protocol Study to Investigate Biomarker-guided Novel Anticancer Agent(s) as Monotherapy or Combination Therapy in Participants With Advanced/Recurrent Ovarian Cancer
- A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
- A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC
- A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
- A Study to Investigate the Biological Effects of Saruparib (AZD5305), Darolutamide, and in Combination in Men With Newly Diagnosed Prostate Cancer.
- A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs
- AZD5305 hADME in Patients With Advanced Solid Malignancies
- Drug-drug Interaction Study With AZD5305 and Itraconazole in Patients With Advanced Solid Malignancies
- Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib
- [Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors](https://trialight.com/data/trial/phase-i-iia-study-of-azd5335-as-monotherapy-and-combination-b67c0c74-ff64-4d06-9240-6e4caac374cf.md)
- Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
- [Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents](https://trialight.com/data/trial/saruparib-azd5305-vs-placebo-in-men-with-metastatic-1a806f0a-2139-4a62-941f-2e57d0cef19b.md)
- [Saruparib in Combination With Physician's Choice of ARPI in Patients With mHSPC Previously Treated With Docetaxel or 177Lu-PSMA Therapy Without Disease Progression and PSA ≥ 0.2 ng/mL (EvoPAR-PR05)](https://trialight.com/data/trial/saruparib-in-combination-with-physician-s-choice-of-arpi-in-152b4168-5216-4c93-b6fe-877cb90d78b4.md)
- Study of AZD4956 as Monotherapy and in Combination With Anti-Cancer Agents in Participants With Advanced/Metastatic Homologous Recombination Deficient Solid Tumours
- Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
- Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer
- Targeted Pathway Inhibition in Patients With Pancreatic Cancer
- Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

### In development for (6)

- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 3
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Metastatic prostate carcinoma](https://trialight.com/data/condition/metastatic-prostate-carcinoma-d5fb1084-bad5-5db6-8240-897dc47ea451.md) Phase 1
- Neoplasm Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 1
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 3

---

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