> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/salmeterol-97bdfb51-b314-47e7-9755-5174e2c52203
> Record changed: 2026-10-13

# Salmeterol

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

First approval year

1994

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

## Development status

**First approval year**

1994

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

**Drug name**

Salmeterol

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

**Molecular weight**

415.57

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

**Structure (SMILES)**

OCc1cc(C(O)CNCCCCCCOCCCCc2ccccc2)ccc1O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

### Other names (29)

- budesonide salmeterol azithromycin
- gr 33343 x
- GR 33343 X
- GR-33343-X
- salmaterol
- Salmaterol
- salmeterol
- Salmeterol
- Salmeterol (as xinafoate)
- Salmeterol (DISKUS)
- SALMETEROL \[HSDB\]
- salmeterol \[INN\]
- SALMETEROL \[MI\]
- SALMETEROL \[USAN\]
- SALMETEROL \[VANDF\]
- Salmeterol \[WHO-DD\]
- Salmeterol 50 mcg BID
- Salmeterol 50 μg
- salmeterol 50mcg
- Salmeterol 50mcg
- salmeterol hsdb
- salmeterol inn
- salmeterol mi
- salmeterol usan
- salmeterol vandf

And 4 more, listed on the interactive page.

## Identifiers

**ATC classification codes**

- R03AC12

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

**CAS registry numbers**

- 89365-50-4

**ChEMBL ID**

CHEMBL1263

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

**InChIKey**

GIIZNNXWQWCKIB-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1263)

**PubChem compound IDs**

- 5152

**RxNorm IDs (RxCUI)**

- 36117

**FDA ingredient codes (UNII)**

- 2I4BC502BT

## Regulatory information

### United States

**Applicant**

GLAXOSMITHKLINE

**Approval date**

4 Feb 1994

**Application number**

NDA020236

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

salmeterol

**Type**

Synthetic organic

**Drug name stem**

sal-; -terol

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- topical

### Mechanisms of action (2)

- **Action**  
Partial agonist

**Action type**  
PARTIAL\_AGONIST

**Target**  
β2-adrenoceptor

**Gene symbol**  
ADRB2

**Protein identifier**  
P07550

**Affinity units**  
pEC50
- **Action**  
Partial agonist

**Action type**  
PARTIAL\_AGONIST

**Target**  
β2-adrenoceptor

**Gene symbol**  
ADRB2

**Protein identifier**  
P07550

**Affinity units**  
pKi

**Primary target**  
Yes

### Open Targets mechanisms

- **Mechanism**  
Beta-2 adrenergic receptor agonist

**Action type**  
Agonist

**Target**  
Beta-2 adrenergic receptor

### DrugCentral mechanisms

- **Action type**  
Agonist

**Gene symbol**  
ADRB2

**Protein identifier**  
P07550

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (8)

- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Emphysema

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000464

**Subject identifier**  
D004646
- **Condition**  
Lung Diseases

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003818

**Subject identifier**  
D008171
- **Condition**  
Bronchitis, Chronic

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0006505

**Subject identifier**  
D029481
- **Condition**  
Bronchiolitis Obliterans

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0007183

**Subject identifier**  
D001989
- **Condition**  
Lung Diseases, Obstructive

**Highest recorded phase**  
4

**Condition identifier**  
HP:0006536

**Subject identifier**  
D008173
- **Condition**  
Asthma

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0004979

**Subject identifier**  
D001249
- **Condition**  
Spinal Cord Injuries

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0043797

**Subject identifier**  
D013119

### Open Targets indications (17)

- **Condition identifier**  
EFO\_0000341
- **Condition identifier**  
EFO\_0000464

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000684
- **Condition identifier**  
EFO\_0006505

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0002094

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0006536
- **Condition identifier**  
HP\_0006536

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0001590

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004784
- **Condition identifier**  
MONDO\_0004849

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004979
- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005002

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005249
- **Condition identifier**  
MONDO\_0005607

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0009061
- **Condition identifier**  
MONDO\_0043797

**Highest recorded phase**  
1

### Open Targets warnings

- **Warning**  
Black Box Warning

**Effect**  
respiratory toxicity

**Country**  
United States

### Reported adverse events (80)

- **Event**  
adrenal insufficiency

**Reports**  
129

**Reporting signal score**

284.707
- **Event**  
adrenal suppression

**Reports**  
66

**Reporting signal score**

256.1
- **Event**  
allergic granulomatous angiitis

**Reports**  
3

**Reporting signal score**

11.1262
- **Event**  
anosmia

**Reports**  
65

**Reporting signal score**

146.93
- **Event**  
asthma

**Reports**  
1,592

**Reporting signal score**  
4,950.3
- **Event**  
asthma-chronic obstructive pulmonary disease overlap syndrome

**Reports**  
49

**Reporting signal score**

239.324
- **Event**  
asthmatic crisis

**Reports**  
48

**Reporting signal score**

149.481
- **Event**  
blood cortisol decreased

**Reports**  
39

**Reporting signal score**

136.767
- **Event**  
blood count abnormal

**Reports**  
277

**Reporting signal score**

735.075
- **Event**  
breath sounds abnormal

**Reports**  
65

**Reporting signal score**

168.264
- **Event**  
bronchial wall thickening

**Reports**  
26

**Reporting signal score**

91.8093
- **Event**  
bronchiectasis

**Reports**  
125

**Reporting signal score**

354.928
- **Event**  
bursitis

**Reports**  
113

**Reporting signal score**

271.48
- **Event**  
candida infection

**Reports**  
59

**Reporting signal score**

88.1872
- **Event**  
central obesity

**Reports**  
26

**Reporting signal score**

86.7186
- **Event**  
chest discomfort

**Reports**  
274

**Reporting signal score**

314.619
- **Event**  
chronic obstructive airways disease exacerbated

**Reports**  
3

**Reporting signal score**

15.5386
- **Event**  
chronic obstructive pulmonary disease

**Reports**  
333

**Reporting signal score**

707.018
- **Event**  
coeliac disease

**Reports**  
114

**Reporting signal score**

333.546
- **Event**  
condition aggravated

**Reports**  
262

**Reporting signal score**

84.8289
- **Event**  
cough

**Reports**  
671

**Reporting signal score**

790.856
- **Event**  
cushing's syndrome

**Reports**  
150

**Reporting signal score**

468.668
- **Event**  
cushingoid

**Reports**  
52

**Reporting signal score**

124.531
- **Event**  
drug hypersensitivity

**Reports**  
375

**Reporting signal score**

201.227
- **Event**  
drug interaction

**Reports**  
14

**Reporting signal score**

12.0288

And 55 more, listed on the interactive page.

### Trial references (122)

- NCT00064402  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00064402)
- NCT00064415  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00064415)
- NCT00116402  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00116402)
- NCT00268177  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00268177)
- NCT00268216  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00268216)
- NCT00269087  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00269087)
- NCT00269126  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00269126)
- NCT00274534  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00274534)
- NCT00274560  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00274560)
- NCT00347139  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00347139)
- NCT00358488  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00358488)
- NCT00364273  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00364273)
- NCT00411372  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00411372)
- NCT00422604  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00422604)
- NCT00531050  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00531050)
- NCT00535366  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00535366)
- NCT00549146  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00549146)
- NCT00605891  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00605891)
- NCT00615030  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00615030)
- NCT00640484  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00640484)
- NCT00642148  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00642148)
- NCT00662740  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00662740)
- NCT00662792  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00662792)
- NCT00668772  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00668772)
- NCT00673478  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00673478)

And 97 more, listed on the interactive page.

## Dosing

**Dose**

1 inhalation

**Route**

Inhalation

**How often**

Twice daily

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

4

**Polar surface area**

81.95

**Calculated partition coefficient (ALogP)**

4.11

**Calculated partition coefficient (XLogP)**

3.9

**Prodrug**

No

**Chirality**

Racemic

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

16

**Heavy atoms**

30

**Molecular formula**

C25H37NO4

**Monoisotopic mass**

415.27225866

**Natural product**

Yes

## Evidence counts

**Recorded assays**

1,111

**Active assays**

171

### Active assay types (3)

- Confirmatory
- Other
- Screening

## Pharmacologic actions

- Adrenergic beta-2 Receptor Agonists  
Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.
- Bronchodilator Agents  
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

1.9

**Mean**

1.77333

**Minimum**

1.06

**Maximum**

2.5

**Unit**

unitless

**Assays**

9

**Standard deviation**

0.522303

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

#### Oral bioavailability

**Median**

10

**Mean**

32.4

**Minimum**

10

**Maximum**

66

**Unit**

%

**Assays**

5

**Standard deviation**

30.6725

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (268)

- A 12 Week Study of QVA149 Compared to Fluticasone/Salmeterol (Advair) for Treatment of COPD
- A 12 Week Study of QVA149 Compared to Fluticasone/Salmeterol (Advair) for Treatment of COPD
- A 12-Month Study Comparing Fluticasone Propionate/Salmeterol (ADVAIR) DISKUS Combination Product 250/50mcg BID To Fluticasone Propionate (FLOVENT) DISKUS 250 mcg BID In Symptomatic Subjects With Asthma
- A 12-Month Study Comparing Fluticasone Propionate/Salmeterol (ADVAIR) DISKUS Combination Product 250/50mcg Twice Daily To Fluticasone Propionate (FLOVENT) DISKUS 250 mcg Twice Daily In Symptomatic Patients With Asthma
- A 12-Week Study To Assess The Safety Of Fluticasone Propionate/Salmeterol 100/50 Hydrofluoroalkane (HFA) Versus Fluticasone Propionate 100 HFA In Children With Asthma
- A 16-Week Study to Evaluate the Effect of Advair DISKUS™ 250/50mcg on Arterial Stiffness in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
- A 24-week Study to Compare Umeclidinium/Vilanterol (UMEC/VI), UMEC and Salmeterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
- A 24-Week Study to Evaluate the Safety and Efficacy of ADVAIR DISKUS® Inhaler 250/50mcg Plus SPIRIVA HANDIHALER® Inhaler Versus SPIRIVA HANDIHALER® Inhaler Plus Placebo DISKUS® Inhaler in Subjects With Chronic Obstructive Pulmonary Disease (COPD).
- A 24-Week Treatment Study to Compare Standard of Care Versus the eMDPI DS in Participants 13 Years or Older With Asthma
- A 26-week Treatment Randomized, Double-blind, Double Dummy Study to Assess the Efficacy and Safety of QVA149
- A 3 Way Cross-over Study Evaluating the Effects of ADOAIR Twice Daily Plus Tiotropium Bromide Once Daily Compared With the Individual Treatments of Japanese Subjects
- A 4-week Dose-Ranging, Dose-Interval, Efficacy, Safety and Tolerability Study of GSK961081 in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
- A Bioequivalence Study Between Fluticasone Salmeterol Xinafoate vs. ADVAIR DISKUS® in Healthy Volunteers
- A Bioequivalence Study Between Fluticasone Salmeterol Xinafoate vs. SERETIDE DISKUS® in Healthy Volunteers With Charcoal Blockade (BREATH-PK250-CC)
- A Blinded Study To Examine The Ability Of PF-610,355 To Open The Airways In Asthmatic Patients.
- A Clinical Trial for Examining the Therapeutic Equivalence Between Fluticasone Propionate 100 mcg and Salmeterol 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 100/50 mcg Inhalation Powder/GSK in Patients With Asthma
- A Comparative Study To Determine If Motivating Asthma Education (Compliance Enhancement) Has An Effect On Asthma Control
- A Comparison of the Effects of Tiotropium Inhalation qd and Salmeterol Inhalation Bid on Arterial Blood Gases.
- A Crossover Study to Determine the 24 Hour Lung Function Profile of Indacaterol in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)
- A Double Blind Open Label Comparator Study to Compare Treatments in 4 to 11 Year Old Patients With Asthma

### Approved for (1)

- Obstructive lung disease

### In development for (7)

- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 3
- Bronchiolitis obliterans syndrome Phase 3
- [Chronic bronchitis](https://trialight.com/data/condition/chronic-bronchitis-1182c6a7-3657-5c56-89e7-6c969a2220da.md) Phase 3
- [Chronic obstructive pulmonary disease](https://trialight.com/data/condition/chronic-obstructive-pulmonary-disease-8e23f74b-95b9-5920-a241-c0278555234f.md) Phase 3
- [Lung disorder](https://trialight.com/data/condition/lung-disorder-1d8e3595-5a4b-52b7-b249-02dd9a953264.md) Phase 2
- [Pulmonary emphysema](https://trialight.com/data/condition/pulmonary-emphysema-7c09e667-0ffb-5ac1-bbd4-bd87b4f05fc6.md) Phase 3
- Spinal cord injury Phase 1

### Other linked conditions (2)

- [Allergic asthma](https://trialight.com/data/condition/allergic-asthma-09fdf0b0-d623-5f2a-9bed-3f05a0ce487a.md)
- Respiratory system disorder

### Targets (1)

- [ADRB2](https://trialight.com/data/target/adrb2-dd50b672-19f0-5015-be62-c6f5861dc510.md) Beta-2 adrenergic receptor agonist

---

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