> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/sacubitril-f4195200-c5a2-450f-b0dd-5f61db1ee02a
> Record changed: 2026-10-13

# Sacubitril

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

First approval year

2015

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

## Development status

**First approval year**

2015

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

**Drug name**

Sacubitril

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

**Molecular weight**

411.5

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

**Structure (SMILES)**

CCOC(=O)\[C@H\](C)C\[C@@H\](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

### Brand names (2)

- sacubitril component of entresto
- Sacubitril component of entresto

### Other names (22)

- ahu 377
- AHU-377
- ahu377
- AHU377
- entresto component sacubitril
- ENTRESTO COMPONENT SACUBITRIL
- sacubitril
- Sacubitril
- sacubitril \[INN\]
- SACUBITRIL \[JAN\]
- SACUBITRIL \[MI\]
- SACUBITRIL \[ORANGE BOOK\]
- SACUBITRIL \[USAN\]
- Sacubitril \[WHO-DD\]
- sacubitril inn
- sacubitril jan
- sacubitril mi
- sacubitril orange book
- sacubitril usan
- sacubitril who dd
- sacubitrilo
- Sacubitrilo

## Identifiers

**CAS registry numbers**

- 149709-62-6

**ChEMBL ID**

CHEMBL3137301

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

**InChIKey**

PYNXFZCZUAOOQC-UTKZUKDTSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3137301)

**PubChem compound IDs**

- 9811834

**RxNorm IDs (RxCUI)**

- 1656328

**FDA ingredient codes (UNII)**

- 17ERJ0MKGI

## Regulatory information

### United States

**Applicant**

NOVARTIS PHARMS CORP

**Approval date**

7 Jul 2015

**Application number**

NDA207620

### Other regulatory facts

**First in class**

Yes

**Orphan designation**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

sacubitril

**Type**

Synthetic organic

**Drug name stem**

\-tril

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral

### Mechanisms of action

- **Mechanism**  
Neprilysin inhibitor

**Action type**  
Inhibitor

**Target**  
Neprilysin

**Protein identifier**  
P08473

### Open Targets mechanisms

- **Mechanism**  
Neprilysin inhibitor

**Action type**  
Inhibitor

**Target**  
Neprilysin

### DrugCentral mechanisms

- **Action type**  
Inhibitor

**Gene symbol**  
MME

**Protein identifier**  
P08473

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (13)

- **Condition**  
Heart Failure

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000373

**Subject identifier**  
D006333
- **Condition**  
Hypertension

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000537

**Subject identifier**  
D006973
- **Condition**  
Cardiomyopathy, Hypertrophic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000538

**Subject identifier**  
D002312
- **Condition**  
Myocardial Infarction

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000612

**Subject identifier**  
D009203
- **Condition**  
Heart Failure

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0003144

**Subject identifier**  
D006333
- **Condition**  
Peripheral Arterial Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004265

**Subject identifier**  
D058729
- **Condition**  
Chagas Cardiomyopathy

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0005529

**Subject identifier**  
D002598
- **Condition**  
Aortic Valve Insufficiency

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007148

**Subject identifier**  
D001022
- **Condition**  
Myocardial Infarction

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0008583

**Subject identifier**  
D009203
- **Condition**  
ST Elevation Myocardial Infarction

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0008585

**Subject identifier**  
D000072657
- **Condition**  
Essential Hypertension

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001134

**Subject identifier**  
D000075222
- **Condition**  
Hypertension, Pulmonary

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005149

**Subject identifier**  
D006976
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (38)

- **Condition identifier**  
EFO\_0000373
- **Condition identifier**  
EFO\_0000537

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000538
- **Condition identifier**  
EFO\_0000612

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0003144
- **Condition identifier**  
EFO\_0003896

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004265

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005109

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005529

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0007148

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0008583
- **Condition identifier**  
EFO\_1001207
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0011105

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001134

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004781

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004995

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005009

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005044

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005045

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005062
- **Condition identifier**  
MONDO\_0005068

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005149

**Highest recorded phase**  
3

And 13 more, listed on the interactive page.

### Reported adverse events (21)

- **Event**  
angioedema

**Reports**  
419

**Reporting signal score**

308.144
- **Event**  
blood creatinine increased

**Reports**  
586

**Reporting signal score**

546.593
- **Event**  
blood potassium increased

**Reports**  
359

**Reporting signal score**

696.548
- **Event**  
blood pressure decreased

**Reports**  
580

**Reporting signal score**

684.134
- **Event**  
cardiac failure

**Reports**  
896

**Reporting signal score**  
1,316.37
- **Event**  
cardiac failure chronic

**Reports**  
142

**Reporting signal score**

343.147
- **Event**  
cough

**Reports**  
990

**Reporting signal score**

530.903
- **Event**  
dizziness

**Reports**  
1,622

**Reporting signal score**

727.857
- **Event**  
dyspnoea

**Reports**  
1,671

**Reporting signal score**

599.075
- **Event**  
ejection fraction decreased

**Reports**  
437

**Reporting signal score**

809.682
- **Event**  
fluid retention

**Reports**  
298

**Reporting signal score**

271.656
- **Event**  
glomerular filtration rate decreased

**Reports**  
196

**Reporting signal score**

307.884
- **Event**  
hyperkalaemia

**Reports**  
502

**Reporting signal score**

610.196
- **Event**  
hypoacusis

**Reports**  
219

**Reporting signal score**

274.203
- **Event**  
hypotension

**Reports**  
3,162

**Reporting signal score**  
4,724.33
- **Event**  
injection site pain

**Reports**  
1

**Reporting signal score**

271.009
- **Event**  
n-terminal prohormone brain natriuretic peptide increased

**Reports**  
108

**Reporting signal score**

317.289
- **Event**  
renal impairment

**Reports**  
486

**Reporting signal score**

322.603
- **Event**  
weight decreased

**Reports**  
639

**Reporting signal score**

227.895
- **Event**  
weight increased

**Reports**  
596

**Reporting signal score**

279.265
- **Event**  
wrong technique in product usage process

**Reports**  
739

**Reporting signal score**

532.606

### Trial references (43)

- NCT00549770  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00549770)
- NCT01281306  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01281306)
- NCT01870739  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01870739)
- NCT04637152  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04637152)
- NCT05545059  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05545059)
- NCT02554890  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02554890)
- NCT02754518  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02754518)
- NCT02787798  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02787798)
- NCT02874794  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02874794)
- NCT02887183  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02887183)
- NCT02900378  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02900378)
- NCT02970669  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02970669)
- NCT03005184  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03005184)
- NCT03066804  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03066804)
- NCT03119623  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03119623)
- NCT03168568  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03168568)
- NCT03300427  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03300427)
- NCT03552575  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03552575)
- NCT03785405  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03785405)
- NCT03988634  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03988634)
- NCT04103554  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04103554)
- NCT04128891  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04128891)
- NCT04572724  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04572724)
- NCT04688294  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04688294)
- NCT05164653  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05164653)

And 18 more, listed on the interactive page.

## Dosing

**Dose**

49 mg/51 mg

**Route**

Oral

**How often**

Twice daily

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

2

**Polar surface area**

92.7

**Calculated partition coefficient (ALogP)**

3.84

**Calculated partition coefficient (XLogP)**

3.7

**Prodrug**

Yes

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

11

**Heavy atoms**

30

**Molecular formula**

C24H29NO5

**Monoisotopic mass**

411.20457303

**Natural product**

Yes

## National Drug Codes

- 0078-0659
- 0078-0696
- 0078-0777
- 0078-1231
- 0078-1238
- 0078-9659
- 0078-9777
- 0904-7580
- 0904-7581
- 0904-7582
- 13668-634
- 13668-635
- 13668-636
- 13668-746
- 13668-747
- 31722-673
- 31722-674
- 31722-675
- 33342-570
- 33342-571
- 33342-572
- 42385-930
- 42385-931
- 42385-932
- 43598-643

And 75 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

24

**Active assays**

0

## Related records

### Trials (119)

- " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD "
- A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions
- A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions
- A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions
- A Cohort Study to Compare the Hospitalization Between Naive Sacubitril/Valsartan and Naive ACEi/ARBs Heart Failure Patients With Reduced Ejection Fraction Using Secondary US Electronic Health Records Data
- [A Phase II Clinical Study of QR12000 Compound Tablets in Patients With Moderate to Severe Essential Hypertension](https://trialight.com/data/trial/a-phase-ii-clinical-study-of-qr12000-compound-tablets-in-039e8548-5a65-4507-be36-db003c696d2e.md)
- A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure
- A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients
- A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 Study
- A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension
- An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic Hypertension
- Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF.
- Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation
- ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling
- ARNI Versus plAcebo in Patients With Congenital sYStemic Right Ventricle Heart Failure
- Bioequivalence Study to Compare Sacubitril and Valsartan Tablets (97mg/103mg) Versus Entresto® (Sacubitril and Valsartan) Tablets (97 mg/103 mg)
- Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)
- Changes in the T-wave Alternans in Patients With Heart Failure Treated Wih Sacubitril-Valsartan
- Comparative Assessment of Efficacy & Safety of Sacubitril/Valsartan Versus Ramipril in Patients With Renal Dysfunction Hospitalized With Acute Decompensated Heart Failure
- Comparing ARNI With ACE Inhibitor on Endothelial Function

### Approved for (2)

- Congestive heart failure
- [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md)

### In development for (11)

- [Acute myocardial infarction](https://trialight.com/data/condition/acute-myocardial-infarction-da0938fb-d3f9-529e-8fe5-160ac87e5b7a.md) Phase 3
- Aortic valve insufficiency Phase 2
- Chagas cardiomyopathy Phase 3
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 1
- [Essential hypertension](https://trialight.com/data/condition/essential-hypertension-bd582df2-4596-58b0-aa00-37f10a4759d3.md) Phase 2
- [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) Phase 3
- [Hypertrophic cardiomyopathy](https://trialight.com/data/condition/hypertrophic-cardiomyopathy-2bcaf1dc-551c-50d7-8f5b-4b8457815d3c.md) Phase 2
- [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) Phase 3
- [Peripheral arterial disease](https://trialight.com/data/condition/peripheral-arterial-disease-660376f2-3d22-5c83-86ea-1d146307e09b.md) Phase 2
- [Pulmonary hypertension](https://trialight.com/data/condition/pulmonary-hypertension-1e275435-e811-5e99-a8d1-abef649a72f4.md) Phase 3
- [ST-elevation myocardial infarction](https://trialight.com/data/condition/st-elevation-myocardial-infarction-4462ec3a-15ca-527b-a581-39887b4bda63.md) Phase 3

### Other linked conditions (1)

- Systolic heart failure

### Targets (1)

- [MME](https://trialight.com/data/target/mme-0b31afed-f137-5b07-94ce-16ae0679e175.md) Neprilysin inhibitor

---

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