Sacituzumab tirumotecan
Highest phase reached
Phase 3
Drug type
Antibody drug conjugate
- Listing at source
- Listed
- Highest phase reached
- Phase 3
- Drug type
- Antibody drug conjugate
- Drug name
- Sacituzumab tirumotecan
- immunoglobulin g1 anti human tumor associated calcium signal transducer 2 human mus musculus monoclonal hrs7 γ1 chain disulfide with human mus musculus monoclonal hrs7 κ chain dimer reduced s 5 6 1 34s 38 amino 34 4 4s 4 ethyl 3 4 12 14 tetrahydro 11 2 1 methylethyl methylsulfonyl amino ethyl 3 14 dioxo 1h pyrano 3 4 6 7 indolizino 1 2 b quinolin 4 yl oxy carbonyl oxy methyl phenyl amino carbonyl 28 32 dioxo 3 6 9 12 15 18 21 24 30 nonaoxa 27 33 diazaoctatriacont 1 yl 1h 1 2 3 triazol 4 yl methyl amino 6 oxo 1 hexyn 1 yl 2 pyrimidinyl l cysteine
- immunoglobulin g1 kappa anti homo sapiens tacstd2 tumor associated calcium signal transducer 2 membrane component chromosome 1 surface marker 1 m1s1 gastrointestinal tumor associated antigen ga7331 pancreatic carcinoma marker protein ga733 1 epithelial glycoprotein 1 egp 1 trophoblast antigen 2 cell surface glycoprotein trop 2 trop2 humanized monoclonal antibody conjugated to the topoisomerase i inhibitor tirumotecan
- immunoglobulin g1 kappa anti homo sapiens tacstd2 tumor associated calcium signal transducer 2 membrane component chromosome 1 surface marker 1 m1s1 gastrointestinal tumor associated antigen ga7331 pancreatic carcinoma marker protein ga733 1 epithelial glycoprotein 1 egp 1 trophoblast antigen 2 cell surface glycoprotein trop 2 trop2 humanized monoclonal antibody conjugated to the topoisomerase i inhibitor tirumotecan gamma1 heavy chain humanized 1 451 vh homo sapiens ighv7 4 1 02 85 70 ighd ighj4 01 86 7 t122 s 115 cdr imgt 8 8 14 26 33 51 58 97 110 1 121 homo sapiens ighg1 03 g1m3 ng1m1ch1 r120 ch3 e12 m14 ch1 r120 218 122 219 hinge 220 234 ch2 235 344 ch3 e12 360 m14 362 345 449 chs 450 451 122 451 224 214 disulfide with kappa light chain humanized 1 214 v kappa homo sapiens igkv1 9 01 82 2 igkj4 01 91 7 g120 a 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 km3 a45 1 153 v101 191 108 214 dimer 230 230 233 233 bisdisulfide produced in chinese hamster ovary cho cells cell line cho s glycoform alfa substituted at the sulfur atoms of eight l cysteinyl residues with 5 6 1 34s 38 amino 34 4 4s 4 ethyl 11 2 n propan 2 yl methanesulfonamido ethyl 3 14 dioxo 3 4 12 14 tetrahydro 1h pyrano 3 4 6 7 indolizino 1 2 b quinolin 4 yl oxy carbonyl oxy methyl phenyl carbamoyl 28 32 dioxo 3 6 9 12 15 18 21 24 30 nonaoxa 27 33 diazaoctatriacontan 1 yl 1h 1 2 3 triazol 4 yl methyl amino 6 oxohex 1 yn 1 yl pyrimidin 2 yl tirumotecan groups
- Immunoglobulin G1-kappa, anti-[Homo sapiens TACSTD2 (tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epithelial glycoprotein-1, EGP-1, trophoblast antigen-2, cell surface glycoprotein Trop-2, TROP2)], humanized monoclonal antibody, conjugated to the topoisomerase I inhibitor tirumotecan
- immunoglobulin G1-kappa, anti-[Homo sapiens TACSTD2 (tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epithelial glycoprotein-1, EGP-1, trophoblast antigen-2, cell surface glycoprotein Trop-2, TROP2)], humanized monoclonal antibody; conjugated to the topoisomerase I inhibitor tirumotecan; gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV7-4-1*02 (85.70%) -(IGHD)-IGHJ4*01 (86.7%) T122>S (115), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*03, G1m3, nG1m1CH1 R120, CH3 E12, M14 (CH1 R120 (218) (122-219), hinge (220-234), CH2 (235-344), CH3 E12 (360), M14 (362) (345-449), CHS (450-451)) (122-451)], (224-214')- disulfide with kappa light chain humanized (1'-214') [V-KAPPA (Homo sapiens IGKV1-9*01 (82.2%) -IGKJ4*01 (91.7%) G120>A (100), CDR-IMGT [6.3.9] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC*01, Km3, A45.1 (153'), V101 (191') (108'-214')]; dimer (230-230":233-233")-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-S, glycoform alfa; substituted at the sulfur atoms of eight L-cysteinyl residues with 5-(6-{[(1-{(34S)-38-amino-34-[(4-{[({[(4S)-4-ethyl-11-{2-[N-(propan-2-yl)methanesulfonamido]ethyl}-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl]oxy}carbonyl)oxy]methyl}phenyl)carbamoyl]-28,32-dioxo-3,6,9,12,15,18,21,24,30-nonaoxa-27,33-diazaoctatriacontan-1-yl}-1H-1,2,3-triazol-4-yl)methyl]amino}-6-oxohex-1-yn-1-yl)pyrimidin-2-yl (tirumotecan) groups
- Immunoglobulin G1, anti-(human tumor-associated calcium signal transducer 2) (human-Mus musculus monoclonal hRS7 γ1-chain), disulfide with human-Mus musculus monoclonal hRS7 κ-chain, dimer, reduced, S-[5-[6-[[[1-[(34S)-38-amino-34-[[[4-[[[[[(4S)-4-ethyl-3,4,12,14-tetrahydro-11-[2-[(1-methylethyl)(methylsulfonyl)amino]ethyl]-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]oxy]carbonyl]oxy]methyl]phenyl]amino]carbonyl]-28,32-dioxo-3,6,9,12,15,18,21,24,30-nonaoxa-27,33-diazaoctatriacont-1-yl]-1H-1,2,3-triazol-4-yl]methyl]amino]-6-oxo-1-hexyn-1-yl]-2-pyrimidinyl]-L-cysteine
- mk 2870
- Mk-2870
- mk2870
- MK2870
- sacituzumab tirumotecan
- Sacituzumab tirumotecan
- Sacituzumab Tirumotecan
- Sacituzumab Tirumotecan (Observational Cohort)
- Sacituzumab tirumotecan (sac-TMT)
- Sacituzumab Tirumotecan (sac-TMT)
- Sacituzumab Tirumotecan (Sac-TMT)
- Sacituzumab Tirumotecan (SKB264)
- sacituzumab tirumotecan [INN]
- SACITUZUMAB TIRUMOTECAN [USAN]
- Sacituzumab tirumotecan [WHO-DD]
- sacituzumab tirumotecan inn
- sacituzumab tirumotecan usan
- sacituzumab tirumotecan who dd
- skb 264
And 4 more, listed on the interactive page.
- CAS registry numbers
- 2768350-77-0
- ChEMBL ID
- CHEMBL5314875
- FDA ingredient codes (UNII)
- 3DV5TD1VL3
- First in class
- No
- Orphan designation
- No
- Pharmacology name
- sacituzumab tirumotecan
- Type
- Antibody
- Drug name stem
- -mab; -mab; -tecan
- Approval recorded by Guide to Pharmacology
- Yes
Mechanisms of action
- Action
- Binding
- Action type
- Binding
- Target
- tumor associated calcium signal transducer 2
- Gene symbol
- TACSTD2
- Protein identifier
- P09758
- Median affinity
- 9.51
- Affinity units
- pKd
- Condition
- Neoplasms
- Highest recorded phase
- 2
- Condition identifier
- EFO:0000616
- Subject identifier
- D009369
- Condition
- Carcinoma, Non-Small-Cell Lung
- Highest recorded phase
- 3
- Condition identifier
- EFO:0003060
- Subject identifier
- D002289
- Condition
- Breast Neoplasms
- Highest recorded phase
- 3
- Condition identifier
- EFO:0003869
- Subject identifier
- D001943
- Condition
- Esophageal Neoplasms
- Highest recorded phase
- 1
- Condition identifier
- EFO:0005922
- Subject identifier
- D004938
- Condition
- Urinary Bladder Neoplasms
- Highest recorded phase
- 1
- Condition identifier
- EFO:0008528
- Subject identifier
- D001749
- Condition
- Uterine Cervical Neoplasms
- Highest recorded phase
- 3
- Condition identifier
- MONDO:0002974
- Subject identifier
- D002583
- Condition
- Breast Neoplasms
- Highest recorded phase
- 3
- Condition identifier
- MONDO:0007254
- Subject identifier
- D001943
- Condition
- Endometrial Neoplasms
- Highest recorded phase
- 3
- Condition identifier
- MONDO:0011962
- Subject identifier
- D016889
- Condition identifier
- EFO_0000616
- Highest recorded phase
- 2
- Condition identifier
- EFO_0003060
- Highest recorded phase
- 3
- Condition identifier
- EFO_0005537
- Highest recorded phase
- 3
- Condition identifier
- EFO_1000576
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0000521
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0002447
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0002974
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0003219
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0004971
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0004992
- Highest recorded phase
- 1
- Condition identifier
- MONDO_0005028
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005036
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005070
- Condition identifier
- MONDO_0005075
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005140
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005153
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0005233
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005494
- Highest recorded phase
- 3
- Condition identifier
- MONDO_0005580
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0006082
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0006260
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0006382
- Condition identifier
- MONDO_0006451
- Highest recorded phase
- 2
- Condition identifier
- MONDO_0006468
- Condition identifier
- MONDO_0007254
- Highest recorded phase
- 3
And 12 more, listed on the interactive page.
- Event
- anaemia
- Reports
- 16
- Reporting signal score
- 12.7972
- Event
- chemotherapy cytokine prophylaxis
- Reports
- 1
- Reporting signal score
- 9.02064
- Event
- chemotherapy side effect prophylaxis
- Reports
- 1
- Reporting signal score
- 8.32754
- Event
- colitis
- Reports
- 7
- Reporting signal score
- 11.3782
- Event
- cytopenia
- Reports
- 4
- Reporting signal score
- 8.6995
- Event
- dairy intolerance
- Reports
- 2
- Reporting signal score
- 12.9169
- Event
- diarrhoea
- Reports
- 26
- Reporting signal score
- 13.7248
- Event
- discontinued product administered
- Reports
- 2
- Reporting signal score
- 11.9114
- Event
- disease progression
- Reports
- 38
- Reporting signal score
- 90.4906
- Event
- disseminated varicella
- Reports
- 1
- Reporting signal score
- 6.71846
- Event
- enteritis
- Reports
- 4
- Reporting signal score
- 10.6055
- Event
- febrile neutropenia
- Reports
- 24
- Reporting signal score
- 51.1387
- Event
- neutropenia
- Reports
- 30
- Reporting signal score
- 48.8089
- Event
- neutropenic colitis
- Reports
- 8
- Reporting signal score
- 36.3007
- Event
- neutrophil count abnormal
- Reports
- 5
- Reporting signal score
- 18.0419
- Event
- neutrophil count decreased
- Reports
- 17
- Reporting signal score
- 38.5591
- Event
- sepsis
- Reports
- 7
- Reporting signal score
- 6.77128
- Event
- skin tightness
- Reports
- 3
- Reporting signal score
- 10.0936
- Event
- therapy change
- Reports
- 4
- Reporting signal score
- 10.5383
- Event
- triple negative breast cancer
- Reports
- 2
- Reporting signal score
- 10.3495
- Event
- ureteric obstruction
- Reports
- 2
- Reporting signal score
- 6.79728
- Event
- white blood cell count decreased
- Reports
- 14
- Reporting signal score
- 17.3864
- Event
- wound infection bacterial
- Reports
- 2
- Reporting signal score
- 9.92988
- NCT05319730
- NCT05347134
- NCT05351788
- NCT05816252
- NCT05870319
- NCT06448312
- NCT05631262
- NCT05642780
- NCT06132958
- NCT06312176
- NCT06459180
- NCT06483334
- Prodrug
- No
- Chirality
- Single enantiomer
- Inorganic
- No
- Natural product
- No
- Component
- Glycosylation sites (N)
- Sequence
- 301 $ 301''
- Component
- Heavy chain
- Type
- Protein
- Sequence
- QVQLQQSGSELKKPGASVKVSCKASGYTFTNYGMNWVKQAPGQGLKWMGWINTYTGEPTYTDDFKGRFAFSLDTSVSTAYLQISSLKADDTAVYFCARGGFGSSYWYFDVWGQGSLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- Component
- Light chain
- Type
- Protein
- Sequence
- DIQLTQSPSSLSASVGDRVSITCKASQDVSIAVAWYQQKPGKAPKLLIYSASYRYTGVPDRFSGSGSGTDFTLTISSLQPEDFAVYYCQQHYITPLTFGAGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- Component
- Disulfide bridges
- Sequence
- 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 148-204 $ 148''-204'' $ 224-214' $ 224''-214''' $ 230-230'' $ 233-233'' $ 265-325 $ 265''-325'' $ 371-429 $ 371'-429''
Related records
Trials (105)
- A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)
- A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
- A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
- A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)
- A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
- A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010)
- A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
- A Clinical Trial of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) to Treat Urothelial Cancer (MK-2870-031)
- A ctDNA-guided Phase II Trial of Osimertinib in Combination With Sacituzumab Tirumotecan in EGFR-mutated Advanced NSCLC Patients With Positive ctDNA After lead-in Osimertinib Monotherapy
- A Phase II Exploratory Study of Sacituzumab Tirumotecan Combined With Envafolimab for TROP2-Positive Advanced Biliary Tract Cancers Previously Treated With First-Line Immunotherapy Combined With Chemotherapy.
- A Phase II Study of Neoadjuvant Sacituzumab Tirumotecan in Combination With Iparomlimab and Tuvonralimab in Locally Advanced Cervical Cancer
- A Phase II Study of Sacituzumab Tirumotecan in Combination With Furmonertinib in Patients With Non-squamous Non-Small Cell Lung Cancer Who Have Progressed After EGFR-TKI and Platinum-Based Chemotherapy
- A Phase II, Investigator-Initiated Exploratory Study of Sacituzumab Tirumotecan for Previously Treated Unresectable Thymic Carcinomas
- A Phase III Study of SKB264 for EGFR Mutant NSCLC Patients
- A Prospective, Single-center, Phase II Study of Sacituzumab Tirumotecan in Combination With Pembrolizumab for Neoadjuvant Treatment of Triple-Negative Breast Cancer (TNBC)
- A Single-Arm, Phase II Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan in Second-Line and Subsequent Treatments for Advanced Thymic Epithelial Tumors
- A Single-center, Multicohort, Phase II Clinical Study Evaluating the Combination Therapy of Sacituzumab Tirumotecan in Patients With Unresectable, Locally Advanced, Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma
- A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)
- A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
- A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)
In development for (10)
- Breast cancer Phase 3
- Breast neoplasm Phase 3
- Cervical cancer Phase 3
- Endometrial cancer Phase 3
- Esophageal squamous cell carcinoma Phase 1
- Neoplasm Phase 2
- Non-small cell lung carcinoma Phase 3
- Thymic carcinoma Phase 2
- Triple-negative breast carcinoma Phase 3
- Urothelial carcinoma Phase 1