> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/sabirnetug-d0728c76-8051-4ddf-9ff8-ad5299e205a7 > Record changed: 2026-10-13 # Sabirnetug Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314772) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314772) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314772) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314772) **Drug name** Sabirnetug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314772) ### Other names (16) - acu 193 - ACU-193 - acu193 - Acu193 - ACU193 - Immunoglobulin G2 \[264-histidine,305-valine,326-alanine,327-proline\], anti-(human Aβ oligomer) (human-Mus musculus monoclonal ACU193 g2-chain), disulfide with human-Mus musculus monoclonal ACU193 k-chain, dimer - immunoglobulin g2 264 histidine 305 valine 326 alanine 327 proline anti human aβ oligomer human mus musculus monoclonal acu193 g2 chain disulfide with human mus musculus monoclonal acu193 k chain dimer - immunoglobulin g2 kappa anti homo sapiens app amyloid beta a4 precursor protein abeta42 and abeta40 soluble non fibrillar oligomers humanized monoclonal antibody gamma2 heavy chain humanized 1 443 vh homo sapiens ighv3 48 01 92 9 ighd ighj4 01 92 9 cdr imgt 8 8 10 26 33 51 58 97 106 1 117 homo sapiens ighg2 01 g2m ch2 v45 1 ch1 118 215 hinge 1 12 216 227 ch2 v45 1 278 228 336 ch3 337 441 chs 442 443 118 443 131 219 disulfide with kappa light chain humanized 1 219 v kappa homo sapiens igkv2 28 01 89 5 igkj2 03 100 cdr imgt 11 3 9 27 37 55 57 94 102 1 112 homo sapiens igkc 01 km3 a45 1 158 v101 196 113 219 dimer 219 219 220 220 223 223 226 226 tetrakisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - immunoglobulin G2-kappa, anti-\[Homo sapiens APP (amyloid beta A4 precursor protein) Abeta42 and Abeta40 soluble non-fibrillar oligomers\], humanized monoclonal antibody; gamma2 heavy chain humanized (1-443) \[VH (Homo sapiens IGHV3-48\*01 (92.9%) -(IGHD) -IGHJ4\*01 (92.9%), CDR-IMGT \[8.8.10\] (26-33.51-58.97-106)) (1-117) -Homo sapiens IGHG2\*01, G2m.. CH2 V45.1 (CH1 (118-215), hinge 1-12 (216-227), CH2 V45.1 (278) (228-336), CH3 (337-441), CHS (442-443)) (118-443)\], (131-219')-disulfide with kappa light chain humanized (1'-219') \[V-KAPPA (Homo sapiens IGKV2-28\*01 (89.5%) -IGKJ2\*03 (100%), CDR-IMGT \[11.3.9\] (27-37.55-57.94-102)) (1'-112') -Homo sapiens IGKC\*01, Km3 A45.1 (158), V101 (196) (113'-219')\]; dimer (219-219'':220-220'':223-223'':226-226'')-tetrakisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - sabirnetug - Sabirnetug - sabirnetug (ACU193) - sabirnetug \[INN\] - SABIRNETUG \[USAN\] - sabirnetug inn - sabirnetug usan ## Identifiers **CAS registry numbers** - 2747959-38-0 **ChEMBL ID** CHEMBL5314772 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314772) **FDA ingredient codes (UNII)** - 2U1A25MKP9 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications - **Condition** Alzheimer Disease **Highest recorded phase** 2 **Condition identifier** MONDO:0004975 **Subject identifier** D000544 ### Open Targets indications - **Condition identifier** MONDO\_0004975 **Highest recorded phase** 2 ### Trial references (2) - NCT04931459 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04931459) - NCT06335173 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06335173) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Glycosylation sites (N) **Sequence** 293 $ 293'' - **Component** Heavy chain **Type** Protein **Sequence** EVQLVESGGGLVQPGGSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAYISRGSSTIYYADTVKGRETISRDNAKNSLYLQMNSLRAEDTAVYYCARGITTALDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTEPAVLQSSGLYSLSSVVTVESSNEGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVELFPPKPKDTLMISRIPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREBQVYTLEPSREEMTENQVSLICLVKGFYPSDIAVEWESNGQPENNYRTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVESCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** DVVMTQSPLSLPVTPGEPASISCRSSQSIVHSNGNTYLEWYLQKPGQSPQLLIYKASNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSRLGPSFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSENRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-93 $ 23'''-93''' $ 131-219' $ 131''-219''' $ 139'-199' $ 139'''-199''' $ 144-200 $ 144''-200'' $ 219-219'' $ 220-220'' $ 223-223'' $ 226-226'' $ 257-317 $ 257''-317'' $ 363-421 $ 363''-421'' ## Related records ### Trials (3) - A Study Comparing the Safety, Tolerability, and Pharmacokinetics of Sabirnetug IV and Sabirnetug + rHuPH20 SC in Healthy Participants - [A Study to Evaluate Efficacy and Safety of Intravenous Sabirnetug in Participants With Early Alzheimer's Disease (ALTITUDE-AD)](https://trialight.com/data/trial/a-study-to-evaluate-efficacy-and-safety-of-intravenous-8dc5f7f2-c3cf-4536-b73e-8d2d71ad6343.md) - A Study to Evaluate the Safety, Tolerability, and Blood Levels of ACU193 in Participants With MCI or Mild AD ### In development for (1) - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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