> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/ruzasvir-d001b6cf-9709-4198-b5c6-49afcab804cb
> Record changed: 2026-10-13

# Ruzasvir

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

**Drug name**

Ruzasvir

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

**Molecular weight**

947.11

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

**Structure (SMILES)**

COC(=O)N\[C@H\](C(=O)N1CCC\[C@H\]1c1ncc(-c2cc(F)c3c(c2)O\[C@@H\](c2cnc(C4CC4)s2)n2c-3cc3cc(-c4cnc(\[C@@H\]5CCCN5C(=O)\[C@@H\](NC(=O)OC)C(C)C)\[nH\]4)ccc32)\[nH\]1)C(C)C

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

### Other names (11)

- mk 8408
- MK-8408
- ruzasvir
- Ruzasvir
- ruzasvir \[INN\]
- RUZASVIR \[USAN\]
- Ruzasvir \[WHO-DD\]
- Ruzasvir 60 mg
- ruzasvir inn
- ruzasvir usan
- ruzasvir who dd

## Identifiers

**CAS registry numbers**

- 1613081-64-3

**ChEMBL ID**

CHEMBL3971095

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

**InChIKey**

AXWDHVUJXNOWCC-RAEGKSCOSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3971095)

**PubChem compound IDs**

- 91936863

**FDA ingredient codes (UNII)**

- LX752BD95Y

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-vir

### Mechanisms of action

- **Mechanism**  
Nonstructural protein 5A inhibitor

**Action type**  
Inhibitor

**Target**  
Nonstructural protein 5A

**Protein identifier**  
Q5L478

### Open Targets mechanisms

- **Mechanism**  
Nonstructural protein 5A inhibitor

**Action type**  
Inhibitor

**Target**  
Nonstructural protein 5A

### Investigated indications (2)

- **Condition**  
Hepatitis C

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003047

**Subject identifier**  
D006526
- **Condition**  
Hepatitis C, Chronic

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004220

**Subject identifier**  
D019698

### Open Targets indications (2)

- **Condition identifier**  
EFO\_0003047

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005231

**Highest recorded phase**  
3

### Trial references (6)

- NCT02076100  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02076100)
- NCT02332707  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02332707)
- NCT02332720  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02332720)
- NCT02956629  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02956629)
- NCT02666352  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02666352)
- NCT02759315  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02759315)

## Chemical properties

**Hydrogen bond acceptors**

12

**Hydrogen bond donors**

4

**Polar surface area**

201.69

**Calculated partition coefficient (ALogP)**

8.59

**Calculated partition coefficient (XLogP)**

6.4

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

3

**Rotatable bonds**

12

**Heavy atoms**

68

**Molecular formula**

C49H55FN10O7S

**Monoisotopic mass**

946.39599347

**Natural product**

No

## Evidence counts

**Recorded assays**

30

**Active assays**

17

### Active assay types

- Confirmatory

## Pharmacologic actions

- Antiviral Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000998.html)

## Biological measurements

### Observed measurements

#### Oral bioavailability

**Median**

13

**Mean**

13

**Minimum**

4

**Maximum**

22

**Unit**

%

**Assays**

2

**Standard deviation**

12.7279

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (13)

- [A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCV](https://trialight.com/data/trial/a-phase-2-safety-and-efficacy-of-bemnifosbuvir-bem-and-98d041bf-0862-4ba7-aa62-61174abac6c8.md)
- A Study of the Pharmacokinetics of Uprifosbuvir (MK-3682) and Ruzasvir (MK-8408) in Participants With Moderate and Severe Hepatic Insufficiency (MK-3682-029)
- Drug-drug Interaction Study of Bemnifosbuvir/Ruzasvir (BEM/RZR) and Ethinyl Estradiol/Levonorgestrel (EE/LNG)
- Drug-drug Interaction Study of Biktarvy and Bemnifosbuvir/Ruzasvir
- Drug-drug Interaction Study of Omeprazole and Bemnifosbuvir/Ruzasvir
- Drug-drug Interaction Study of Ruzasvir and Bemnifosbuvir
- Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and GT2 Infection (MK-3682-011)
- Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Virus (HCV) Genotype (GT) 3, GT4, GT5, and GT6 Infection (MK-3682-012)
- Efficacy and Safety of Uprifosbuvir (MK-3682) + Ruzasvir (MK-8408) in Treating Hepatitis C Virus Infection Genotypes 1-6 (MK-3682-041)
- Efficacy and Safety of Uprifosbuvir (MK-3682) With Ruzasvir (MK-8408) in Adults With Chronic Hepatitis C Genotype 1, 2, 3, 4, 5 or 6 Infection (MK-3682-035)
- Pharmacokinetics of Fixed-Dose Combination Tablet of Bemnifosbuvir and Ruzasvir
- Safety, Pharmacokinetics, and Pharmacodynamics of Ruzasvir (MK-8408) in Participants With Hepatitis C Infection (MK-8408-003)
- Study of Bemnifosbuvir/Ruzasvir as a Fixed-dose Combination in Subjects With Normal or Severely Impaired Renal or Hepatic Function

### In development for (2)

- [Chronic hepatitis C virus infection](https://trialight.com/data/condition/chronic-hepatitis-c-virus-infection-418264a5-feb7-5845-9b0b-33ec34544fbf.md) Phase 2
- Hepatitis C virus infection Phase 2

---

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