> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/rotigaptide-bb594923-f30b-49ff-a57b-b85c7e052627 > Record changed: 2026-10-13 # Rotigaptide Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) **Drug name** Rotigaptide Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) **Molecular weight** 617.66 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) **Structure (SMILES)** CC(=O)N\[C@H\](Cc1ccc(O)cc1)C(=O)N1CCC\[C@@H\]1C(=O)N1C\[C@@H\](O)C\[C@@H\]1C(=O)NCC(=O)N\[C@H\](C)C(=O)NCC(N)=O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) ### Other names (18) - GAP (WYETH) - gap 486 zp 123 - gap wyeth - GAP-486 (ZP-123) - Prevnar®: (Wyeth) - rotigaptida - Rotigaptida - rotigaptide - Rotigaptide - rotigaptide \[INN\] - ROTIGAPTIDE \[USAN\] - rotigaptide inn - rotigaptide usan - The conjugate vaccine used is Prevnar (Wyeth-Ayerst vaccines) - zp 123 - zp 123 zealand - ZP-123 - ZP-123 (ZEALAND) ## Identifiers **CAS registry numbers** - 355151-12-1 **ChEMBL ID** CHEMBL450656 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) **InChIKey** GFJRASPBQLDRRY-TWTQBQJDSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL450656) **PubChem compound IDs** - 9938933 **FDA ingredient codes (UNII)** - GFA1W6KO7N ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** rotigaptide **Type** Peptide **Drug name stem** \-tide ### Investigated indications - **Condition** Arrhythmias, Cardiac **Highest recorded phase** 2 **Condition identifier** EFO:0004269 **Subject identifier** D001145 ### Open Targets indications (5) - **Condition identifier** EFO\_0004269 **Highest recorded phase** 2 - **Condition identifier** EFO\_1001461 - **Condition identifier** HP\_0004308 **Highest recorded phase** 2 - **Condition identifier** HP\_0011675 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005068 ### Trial references (2) - NCT00137293 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00137293) - NCT00137332 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00137332) ## Chemical properties **Hydrogen bond acceptors** 9 **Hydrogen bond donors** 7 **Polar surface area** 240.57 **Calculated partition coefficient (ALogP)** \-3.39 **Calculated partition coefficient (XLogP)** \-2.3 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 2 **Rotatable bonds** 12 **Heavy atoms** 44 **Molecular formula** C28H39N7O9 **Monoisotopic mass** 617.28092585 **Natural product** Yes ## Evidence counts **Recorded assays** 7 **Active assays** 0 ## Related records ### Trials (102) - A Clinical Trial of Autologous Oxidized Tumor Cell Lysate Vaccine For Recurrent Ovarian, Fallopian Tube or Primary Peritoneal Cancer - A Phase 1b Clinical Trial of 13-valent Pneumococcal Polysaccharide Conjugate Vaccine - [A Phase 2 Study to Evaluate the Safety, Tolerability, and Immune Response of AFX3772 Vaccine in Healthy Infants](https://trialight.com/data/trial/a-phase-2-study-to-evaluate-the-safety-tolerability-and-f713a4eb-756c-4f54-8a2c-61c33a40411b.md) - A Phase 2, Multicenter, Open-label Study to Assess the Immunogenicity of an Investigational Hib Vaccine (NU300)in Toddlers - A Phase III Clinical Trial of a 13-valent Pneumococcal Conjugate Vaccine in Healthy Infants - A Protocol to Collect Human Serum Samples From Healthy Adults for Use as Quality Controls Samples in GlaxoSmithKline (GSK) Biologicals' Assays - A Study of Pneumococcal Conjugate Vaccine (V114) Compared to a Marketed Vaccine (V114-003) - A Study of Three Different Doses of VAC52416 (ExPEC10V) in Adults Aged 60 to 85 Years in Stable Health - A Study of V118 Formulation C (V118C) in Healthy Participants (V118C-001) - A Study of V118E in Healthy Participants (V118E-003) - [A Study of V132 in Healthy Older Participants (V132-001)](https://trialight.com/data/trial/a-study-of-v132-in-healthy-older-participants-v132-001-5b90c787-052e-49a2-968a-a19837fed2ab.md) - A Study of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-006) - A Study to Evaluate the Immunogenicity and Safety of 13-valent Pneumococcal Conjugate Vaccine (PCV13i) in Healthy Infants Aged 2 Months (Minimum 6 Weeks) - A Study to Evaluate the Interchangeability of V114 and Prevnar 13™ in Healthy Infants (V114-027/PNEU-DIRECTION) - A Study to Evaluate the Safety and Tolerability of V114 and Prevnar 13™ in Healthy Infants (V114-031/PNEU-LINK) - A Study to Evaluate the Safety, Tolerability and Immunogenicity of V114 in Healthy Adults and Infants (V114-005) - A Study to Evaluate the Safety, Tolerability, and Immunogenicity of Two Lots of V114 in Healthy Infants (V114-008) - A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults at Increased Risk for Pneumococcal Disease (V114-017/PNEU-DAY) - A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults Infected With Human Immunodeficiency Virus (HIV) (V114-018) - A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Healthy Adults 50 Years of Age or Older (V114-016/PNEU-PATH) ### In development for (1) - Cardiac rhythm disease Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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