> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/rosnilimab-8ca98c26-a5b2-49fc-be53-027947c36ad5
> Record changed: 2026-10-13

# Rosnilimab

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095287)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095287)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095287)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095287)

**Drug name**

Rosnilimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095287)

### Other names (14)

- anb 030
- ANB-030
- anb030
- ANB030
- immunoglobulin g1 anti human programmed cell death protein 1 human mus musculus monoclonal anb030 gamma 1 chain disulfide with human mus musculus monoclonal anb030 kappa chain dimer
- IMMUNOGLOBULIN G1, ANTI-(HUMAN PROGRAMMED CELL DEATH PROTEIN 1) (HUMAN-MUS MUSCULUS MONOCLONAL ANB030 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL ANB030 .KAPPA.-CHAIN, DIMER
- rosnilimab
- Rosnilimab
- rosnilimab \[INN\]
- ROSNILIMAB \[USAN\]
- Rosnilimab \[WHO-DD\]
- rosnilimab inn
- rosnilimab usan
- rosnilimab who dd

## Identifiers

**CAS registry numbers**

- 2412764-40-8

**ChEMBL ID**

CHEMBL5095287

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095287)

**FDA ingredient codes (UNII)**

- 93OKX5KD2L

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

rosnilimab

**Type**

Antibody

**Drug name stem**

\-mab

### Mechanisms of action (2)

- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
programmed cell death 1 (CD279)

**Gene symbol**  
PDCD1

**Protein identifier**  
Q15116

**Median affinity**

6.3

**Affinity units**  
pIC50
- **Action**  
Agonist

**Action type**  
Agonist

**Target**  
programmed cell death 1 (CD279)

**Gene symbol**  
PDCD1

**Protein identifier**  
Q15116

**Median affinity**

10.29

**Affinity units**  
pKd

### Investigated indications (4)

- **Condition**  
Arthritis, Rheumatoid

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000685

**Subject identifier**  
D001172
- **Condition**  
Colitis, Ulcerative

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000729

**Subject identifier**  
D003093
- **Condition**  
Alopecia Areata

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004192

**Subject identifier**  
D000506
- **Condition**  
Autoimmune Diseases

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005809

**Subject identifier**  
D001327

### Open Targets indications (8)

- **Condition identifier**  
EFO\_0000685

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000729

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004192

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005809
- **Condition identifier**  
MONDO\_0005101

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005340

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0007179
- **Condition identifier**  
MONDO\_0008383

**Highest recorded phase**  
2

### Trial references (3)

- NCT05205070  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05205070)
- NCT06041269  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06041269)
- NCT06127043  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06127043)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
QVQLVQSGSELKKPGASVKVSCKASNYTFTDYSMHWVRQAPGQGLEWMGWINIETYYPTYADQFKGRFAFSLDTSVSTAYLQISSLKAEDTAVYYCARDYYGRFYYAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
EIVLTQSPATLSLSPGERATLSCTASSSVSSSYFHWYQQKPGQAPRLLIYSTSNLASGIPARFSGSGSGTDFTLTISRLEPEDFAVYYCHQYHRSPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKKVYACEVTHQVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHGLSSPVTKSFNRGEC
- **Component**  
Glycosylation sites (N)

**Sequence**  
301 $ 301''''
- **Component**  
Disulfide bridges

**Sequence**  
22-96 $ 22''-96'' $ 23'-89' $ 23'''-89''' $ 135'-195' $ 135'''-195''' $ 148-204 $ 148''-204'' $ 224-215' $ 224''-215''' $ 230-230'' $ 233-233'' $ 265-325 $ 265''-325'' $ 371-429 $ 371''-429''
- **Component**  
Glycosylation sites (N)

**Sequence**  
301 $ 301''

## Related records

### Trials (3)

- [A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)](https://trialight.com/data/trial/a-study-of-efficacy-and-safety-of-rosnilimab-in-subjects-8b4c8246-64a9-45a6-a739-87d6dbd956c2.md)
- A Study of Efficacy and Safety of Rosnilimab in Subjects With Moderate to Severe Ulcerative Colitis (ROSETTA)
- A Study to Evaluate the Efficacy and Safety of Rosnilimab (ANB030) in Treatment of Subjects With Moderate-to-Severe Alopecia Areata

### In development for (4)

- [Alopecia areata](https://trialight.com/data/condition/alopecia-areata-8709d8ab-db3b-57e6-88fa-7d7ae93d4561.md) Phase 2
- [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) Phase 2
- [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2
- [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 2

---

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