> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/rocatinlimab-62634da9-46fe-4969-8859-264ab7ebf719 > Record changed: 2026-10-13 # Rocatinlimab Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594567) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594567) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594567) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594567) **Drug name** Rocatinlimab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594567) ### Other names (25) - amg 451 - AMG 451 - AMG-451 - amg451 - AMG451 - immunoglobulin g1 anti human cd134 antigen human monoclonal khk4083 γ1 chain disulfide with human monoclonal khk4083 κ chain dimer - immunoglobulin g1 kappa anti homo sapiens tnfrsf4 tumor necrosis factor receptor tnfr superfamily member 4 ox40 cd134 homo sapiens monoclonal antibody gamma1 heavy chain homo sapiens 1 447 vh homo sapiens ighv2 5 02 94 0 ighd ighj1 01 100 cdr imgt 10 7 9 26 35 53 59 98 106 1 117 homo sapiens ighg1 01 100 g1m17 1 ch1 k120 214 118 215 hinge 1 15 216 230 ch2 231 340 ch3 d12 356 l14 358 341 445 chs 446 447 118 447 220 214 disulfide with kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv3 20 01 98 9 igkj4 01 100 cdr imgt 7 3 8 27 33 51 53 90 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 226 226 229 229 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa - immunoglobulin G1-kappa, anti-\[Homo sapiens TNFRSF4 (tumor necrosis factor receptor (TNFR) superfamily member 4, OX40, CD134)\], Homo sapiens monoclonal antibody; gamma1 heavy chain Homo sapiens (1-447) \[VH (Homo sapiens IGHV2-5\*02 (94.0%) -(IGHD) - IGHJ1\*01 (100%), CDR-IMGT \[10.7.9\] (26-35.53- 59.98-106)) (1-117) -Homo sapiens IGHG1\*01 (100%), G1m17,1 (CH1 K120 (214) (118-215), hinge 1-15 (216-230), CH2 (231-340), CH3 D12 (356), L14 (358) (341-445), CHS (446-447)) (118-447)\], (220-214')- disulfide with kappa light chain Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV3-20\*01 (98.9%) - IGKJ4\*01 (100%), CDR-IMGT \[7.3.8\] (27-33.51-53.90- 97)) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')\]; dimer (226- 226'':229-229'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa - Immunoglobulin G1, anti-(human CD134 antigen) (human monoclonal KHK4083 γ1-chain), disulfide with human monoclonal KHK4083 κ-chain, dimer - khk 4083 - Khk-4083 - KHK-4083 - khk4083 - Khk4083 - KHK4083 - klk4083 - KLK4083 - rocatinlimab - Rocatinlimab - rocatinlimab \[INN\] - ROCATINLIMAB \[USAN\] - Rocatinlimab \[WHO-DD\] - rocatinlimab inn - rocatinlimab usan - rocatinlimab who dd ## Identifiers **CAS registry numbers** - 2431972-52-8 **ChEMBL ID** CHEMBL4594567 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4594567) **FDA ingredient codes (UNII)** - G770V925KP ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** rocatinlimab **Type** Antibody **Drug name stem** \-mab ### Mechanisms of action (2) - **Mechanism** Tumor necrosis factor receptor superfamily member 4 antagonist **Action type** Antagonist **Target** Tumor necrosis factor receptor superfamily member 4 **Protein identifier** P43489 - **Action** Inhibition **Action type** Inhibitor **Target** OX40 **Gene symbol** TNFRSF4 **Protein identifier** P43489 ### Open Targets mechanisms - **Mechanism** Tumor necrosis factor receptor superfamily member 4 antagonist **Action type** Antagonist **Target** Tumor necrosis factor receptor superfamily member 4 ### Investigated indications (2) - **Condition** Dermatitis, Atopic **Highest recorded phase** 3 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Colitis, Ulcerative **Highest recorded phase** 1 **Condition identifier** EFO:0000729 **Subject identifier** D003093 ### Open Targets indications (6) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0026045 **Highest recorded phase** 3 ### Trial references (12) - NCT02985593 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02985593) - NCT03703102 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03703102) - NCT05398445 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05398445) - NCT05633355 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05633355) - NCT05651711 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05651711) - NCT05704738 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05704738) - NCT05724199 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05724199) - NCT05882877 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05882877) - NCT05891119 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05891119) - NCT05899816 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05899816) - NCT06214481 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06214481) - NCT06438263 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06438263) ## Chemical properties **Prodrug** No **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Glycosylation sites (N) **Sequence** 297 $ 297' - **Component** Heavy chain **Type** Protein **Sequence** QITLKESGPTLVKPKQTLTLTCTFSGFSLSTSGMGVGWIRQPPGKALEWLAVIYWDDHQLYSPSLKSRLTITKDTSKNQVVLTMTNMDPVDTATYYCAHRRGAFQHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-97 $ 22'-97' $ 23''-89'' $ 23'''-89''' $ 134''-194'' $ 134'''-194''' $ 144-200 $ 144'-200' $ 220'-214''' $ 220-214'' $ 226-226' $ 229-229' $ 261-321 $ 261'-321' $ 367-425 $ 367'-425' - **Component** Light chain **Type** Protein **Sequence** EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYDSSLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC ## Related records ### Trials (18) - A Phase 1 Study of KHK4083 in Healthy Volunteers and Subjects With Ulcerative Colitis - A Phase 1 Study of KHK4083 in Subjects With Atopic Dermatitis - [A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma](https://trialight.com/data/trial/a-phase-2-dose-ranging-study-assessing-rocatinlimab-in-615ff7dd-ab2f-42ca-8386-b1206a1e395d.md) - A Phase 3, Placebo-controlled, Double-blind Study Assessing Rocatinlimab in Prurigo Nodularis - A Study Assessing Rocatinlimab (AMG 451) Monotherapy in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon) - A Study Assessing Rocatinlimab in Combination With Topical Corticosteroid and/or Topical Calcineurin Inhibitors in Adult Participants With Moderate-to-severe Atopic Dermatitis (AD) - A Study Assessing Rocatinlimab on Vaccine Antibody Response in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET - VOYAGER) - A Study Evaluating Rocatinlimab in Moderate-to-severe Atopic Dermatitis (ROCKET-IGNITE) - [A Study to Assess Bioavailability of Rocatinlimab (AMG 451) Vial and Prefilled Syringe in Healthy Participants](https://trialight.com/data/trial/a-study-to-assess-bioavailability-of-rocatinlimab-amg-451-c8bc78eb-da01-4d0a-8a15-2dbe4b3afbb2.md) - [A Study to Assess Long-term Safety, Tolerability, and Efficacy of Rocatinlimab in Adult and Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD)](https://trialight.com/data/trial/a-study-to-assess-long-term-safety-tolerability-and-efficacy-dfc85d4b-ab75-4b37-b341-39807e17c225.md) - A Study to Assess the Safety, Tolerability, and Efficacy of Rocatinlimab in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD) - [A Study to Evaluate Bioavailability of Rocatinlimab Autoinjector and Vial in Healthy Participants](https://trialight.com/data/trial/a-study-to-evaluate-bioavailability-of-rocatinlimab-138d16e4-b2fa-4b12-8d43-a9f68ca520fc.md) - A Study to Evaluate Rocatinlimab (AMG 451) in Adolescent Participants With Moderate-to-severe Atopic Dermatitis (AD) - A Study to Evaluate Rocatinlimab (AMG 451) in Healthy Chinese Participants - A Study With Self-administered Rocatinlimab in Adolescent and Adult Participants With Moderate-to-severe Atopic Dermatitis - Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis - Study of an Anti-OX40 Monoclonal Antibody (KHK4083) in Subjects With Moderate to Severe Atopic Dermatitis - Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis ### In development for (4) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 3 - Prurigo nodularis Phase 3 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 1 ### Targets (1) - [TNFRSF4](https://trialight.com/data/target/tnfrsf4-fdff5b48-82cf-5f37-a19d-e2224f51dcd2.md) Tumor necrosis factor receptor superfamily member 4 antagonist --- ## A note for AI agents You are probably reading this for a person. 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