> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ro-0622-1855dd7f-0857-4056-8d15-a6ea7b8391aa > Record changed: 2026-10-29 # RO-0622 Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL519846) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL519846) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL519846) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL519846) **Drug name** RO-0622 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL519846) **Molecular weight** 286.22 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL519846) **Structure (SMILES)** These details could not be displayed. ### Other names (12) - azvudine - Azvudine - AZVUDINE - Azvudine \[WHO-DD\] - Azvudine tablets - Azvudine tablets(FNC) - azvudine who dd - fnc - FNC - ro 0622 - RO 0622 - Ro-0622 ## Identifiers **CAS registry numbers** - 1011529-10-4 **ChEMBL ID** CHEMBL519846 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL519846) **InChIKey** KTOLOIKYVCHRJW-XZMZPDFPSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL519846) **FDA ingredient codes (UNII)** - IJ2XP0ID0K ### PubChem compound IDs (2) - 24769759 - 163325167 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** azvudine **Type** Synthetic organic ### Mechanisms of action (3) - **Mechanism** Human immunodeficiency virus type 1 reverse transcriptase inhibitor **Action type** Inhibitor **Target** Human immunodeficiency virus type 1 reverse transcriptase **Protein identifier** Q72547 - **Mechanism** Replicase polyprotein 1ab inhibitor **Action type** Inhibitor **Target** Replicase polyprotein 1ab **Protein identifier** P0DTD1 - **Mechanism** Reverse transcriptase inhibitor **Action type** Inhibitor **Target** Reverse transcriptase **Protein identifier** Q06347 ### Open Targets mechanisms (3) - **Mechanism** Human immunodeficiency virus type 1 reverse transcriptase inhibitor **Action type** Inhibitor **Target** Human immunodeficiency virus type 1 reverse transcriptase - **Mechanism** Replicase polyprotein 1ab inhibitor **Action type** Inhibitor **Target** Replicase polyprotein 1ab - **Mechanism** Reverse transcriptase inhibitor **Action type** Inhibitor **Target** Reverse transcriptase ### Investigated indications - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** MONDO:0100096 **Subject identifier** D045169 ### Open Targets indications (3) - **Condition identifier** HP\_0000083 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005344 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0100096 **Highest recorded phase** 3 ### Trial references (5) - NCT04668235 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04668235) - NCT05033145 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05033145) - NCT05633433 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05633433) - NCT05682599 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05682599) - NCT05689034 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05689034) ## Chemical properties **Hydrogen bond acceptors** 8 **Hydrogen bond donors** 3 **Polar surface area** 159.36 **Calculated partition coefficient (ALogP)** \-0.95 **Calculated partition coefficient (XLogP)** \-0.8 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 3 **Heavy atoms** 20 **Molecular formula** C9H11FN6O4 **Monoisotopic mass** 286.08258102 **Natural product** No ## Evidence counts **Recorded assays** 75 **Active assays** 20 ### Active assay types - Confirmatory ## Related records ### Trials (23) - \[14C\] Mass Balance Clinical Trial of Azvudine in Healthy Male Subjects - A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Aluvia - A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Dolutegravir Sodium Tablets (DTG) - A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Itraconazole Capsules (ICZ) - A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Rifampicin Capsules (RIF) - A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Rilpivirine Tablets (RPV) - A Clinical Study of the Interactions Between Azvudine Tablets (FNC) and Tenofovir Alafenol Fumarate Tablets (TAF) - A Clinical Trial for Azvudine in the Treatment of Novel Coronavirus Pneumonia (COVID-19） - A Pharmacokinetics and Safety Study of Azvudine Tablets in Subjects With Mild-To-Moderate GFR Decline in Renal Insufficiency and in Healthy Subjects - A Small Sample Prospective Clinical Study of Azvudine Tablets to Promote Clinical Cure in Patients With Chronic Hepatitis B - A Study of Efficacy and Safety of Azvudine vs. Nirmatrelvir-Ritonavir in the Treatment of COVID-19 Infection - A Study to Evaluate the Pharmacokinetics and Safety of Azvudine Tablets in Healthy Adult Subjects and Healthy Elderly Subjects - An Observational, Ambispective Cohort Study of Azvudine in the Treatment of Patients With COVID-19 Pneumonia - [Evaluate Azvudine in Preventing SARS-Cov-2 Infection in Household Contacts of Covid-19 in China](https://trialight.com/data/trial/evaluate-azvudine-in-preventing-sars-cov-2-infection-in-d2694d23-df0c-476c-aeba-7eb4bc95959f.md) - [Evaluate the Efficacy and Safety of Azvudine in Preventing SARS-Cov-2 Infection in Household Contacts of Covid-19](https://trialight.com/data/trial/evaluate-the-efficacy-and-safety-of-azvudine-in-preventing-901801dc-7ffe-469c-a69e-87fb40f66fc2.md) - Multicenter Randomized Double-blind Placebo-controlled Study to Investigate Azvudine in Symptomatic Adults With COVID-19 at Increased Risk of Progressing to Severe Illness - Phase III Clinical Study of Azvudine in Hiv-infected Treatment Naive Patients - Real-world Study Evaluating the Efficacy and Safety of Azvudine in Nursing Home Patients - Risk Factors for Severe Disease in Hospitalized Patients With COVID-19 and the Effect of Azvudine Treatment: a Retrospective Cohort Study - Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (SARS-CoV-2 Infected) ### In development for (1) - [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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