> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/rizatriptan-benzoate-2cd62623-7391-4fcf-a9bc-eaf423acd979 > Record changed: 2026-11-04 # Rizatriptan benzoate Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) First approval year 1998 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) ## Development status **First approval year** 1998 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) **Drug name** Rizatriptan benzoate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) **Molecular weight** 391.48 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) **Structure (SMILES)** CN(C)CCc1c\[nH\]c2ccc(Cn3cncn3)cc12.O=C(O)c1ccccc1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) ### Brand names (8) - maxalt - Maxalt - maxalt mlt - Maxalt-mlt - rizafilm - Rizafilm - rizatriptan benzoate - Rizatriptan benzoate ### Other names (37) - maxalt 10mg mlt - Maxalt 10mg MLT - mk 0462 - MK-0462 - nsc 758919 - NSC-758919 - rizafilm - Rizafilm - rizatriptan benzoate - Rizatriptan benzoate - Rizatriptan Benzoate - rizatriptan benzoate (MK0462) - RIZATRIPTAN BENZOATE \[EP MONOGRAPH\] - RIZATRIPTAN BENZOATE \[JAN\] - RIZATRIPTAN BENZOATE \[MART.\] - RIZATRIPTAN BENZOATE \[MI\] - RIZATRIPTAN BENZOATE \[ORANGE BOOK\] - RIZATRIPTAN BENZOATE \[USAN\] - RIZATRIPTAN BENZOATE \[USP MONOGRAPH\] - RIZATRIPTAN BENZOATE \[USP-RS\] - RIZATRIPTAN BENZOATE \[VANDF\] - Rizatriptan benzoate \[WHO-DD\] - rizatriptan benzoate 10 mg - rizatriptan benzoate 5 mg - rizatriptan benzoate ep monograph And 12 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 145202-66-0 **ChEMBL ID** CHEMBL1201032 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) **InChIKey** JPRXYLQNJJVCMZ-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1201032) **RxNorm IDs (RxCUI)** - 237082 **FDA ingredient codes (UNII)** - WR978S7QHH ### PubChem compound IDs (2) - 77997 - 68473071 ## Regulatory information ### United States **Applicant** ORGANON LLC **Approval date** 29 Jun 1998 **Application number** NDA020864 ### Other regulatory facts **Patents** 1 **Designations** 0 **Earliest recorded loss of exclusivity** 30 Jul 2034 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No **Availability** Prescription only **Boxed warning** Yes ## Approval status **United States (FDA)** Approved ## Pharmacology ### Drug classification **Pharmacology name** rizatriptan **Type** Synthetic organic **Drug name stem** \-triptan #### Administration routes - Oral ### Mechanisms of action (2) - **Mechanism** Serotonin 1b (5-HT1b) receptor agonist **Action type** Agonist **Target** 5-hydroxytryptamine receptor 1B **Protein identifier** P28222 - **Mechanism** Serotonin 1d (5-HT1d) receptor agonist **Action type** Agonist **Target** 5-hydroxytryptamine receptor 1D **Protein identifier** P28221 ### Open Targets mechanisms (2) - **Mechanism** Serotonin 1b (5-HT1b) receptor agonist **Action type** Agonist **Target** 5-hydroxytryptamine receptor 1B - **Mechanism** Serotonin 1d (5-HT1d) receptor agonist **Action type** Agonist **Target** 5-hydroxytryptamine receptor 1D ### Investigated indications (3) - **Condition** Migraine Disorders **Highest recorded phase** 4 **Condition identifier** MONDO:0005277 **Subject identifier** D008881 - **Condition** Migraine with Aura **Highest recorded phase** 3 **Condition identifier** MONDO:0005475 **Subject identifier** D020325 - **Condition** Migraine without Aura **Highest recorded phase** 3 **Condition identifier** MONDO:0100431 **Subject identifier** D020326 ### Open Targets indications (4) - **Condition identifier** MONDO\_0005277 - **Condition identifier** MONDO\_0005277 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005475 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0100431 **Highest recorded phase** 3 ### Warnings - **Warning** Black Box Warning ### Open Targets warnings - **Warning** Black Box Warning **Country** United States ### Reported adverse events (67) - **Event** abdominal pain **Reports** 36 **Reporting signal score** 12.9843 - **Event** abdominal pain upper **Reports** 27 **Reporting signal score** 13.4301 - **Event** acute respiratory failure **Reports** 12 **Reporting signal score** 20.2922 - **Event** alanine aminotransferase increased **Reports** 22 **Reporting signal score** 14.3632 - **Event** anuria **Reports** 13 **Reporting signal score** 27.8633 - **Event** aspartate aminotransferase increased **Reports** 21 **Reporting signal score** 14.8521 - **Event** atheroembolism **Reports** 3 **Reporting signal score** 13.4378 - **Event** blood chloride decreased **Reports** 6 **Reporting signal score** 13.6439 - **Event** broad ligament tear **Reports** 3 **Reporting signal score** 21.9256 - **Event** carotid artery dissection **Reports** 7 **Reporting signal score** 29.417 - **Event** chest discomfort **Reports** 27 **Reporting signal score** 22.4586 - **Event** chest pain **Reports** 32 **Reporting signal score** 15.5779 - **Event** colitis ischaemic **Reports** 27 **Reporting signal score** 81.4397 - **Event** coronary artery dissection **Reports** 10 **Reporting signal score** 40.0367 - **Event** cough **Reports** 38 **Reporting signal score** 16.2122 - **Event** drug abuse **Reports** 24 **Reporting signal score** 24.0348 - **Event** drug hypersensitivity **Reports** 48 **Reporting signal score** 21.9553 - **Event** drug interaction **Reports** 47 **Reporting signal score** 27.9695 - **Event** duodenal ulcer **Reports** 8 **Reporting signal score** 12.7222 - **Event** extrapyramidal disorder **Reports** 13 **Reporting signal score** 19.3264 - **Event** gallbladder polyp **Reports** 14 **Reporting signal score** 65.7329 - **Event** gastritis **Reports** 13 **Reporting signal score** 15.7596 - **Event** gastroenteritis radiation **Reports** 5 **Reporting signal score** 20.9084 - **Event** glaucoma **Reports** 9 **Reporting signal score** 12.9947 - **Event** granulosa cell tumour of the testis **Reports** 2 **Reporting signal score** 14.3805 And 42 more, listed on the interactive page. ### Trial references (17) - NCT00092963 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00092963) - NCT00095004 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00095004) - NCT00111709 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00111709) - NCT00111722 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00111722) - NCT00516737 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00516737) - NCT00604812 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00604812) - NCT00719134 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00719134) - NCT00753311 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00753311) - NCT00812006 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00812006) - NCT00897104 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00897104) - NCT00897949 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00897949) - NCT00898677 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00898677) - NCT00899379 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00899379) - NCT01004263 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01004263) - NCT04384367 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04384367) - NCT06473597 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06473597) - NCT00471952 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00471952) ## Dosing **Dose** 5-10 mg **Route** Oral **How often** As needed ### Conditions of use (3) - Do not exceed 30 mg in 24 hours - Single 5 mg dose in patients on propranolol weighing 40 kg or more - Up to 3 doses in 24 hours in adult patients taking propranolol ## Chemical properties **Hydrogen bond acceptors** 4 **Hydrogen bond donors** 1 **Polar surface area** 49.74 **Calculated partition coefficient (ALogP)** 1.91 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 5 **Heavy atoms** 29 **Molecular formula** C22H25N5O2 **Monoisotopic mass** 391.20082506 **Natural product** No ## National Drug Codes - 0093-7471 - 0093-7472 - 29300-268 - 29300-269 - 29300-316 - 29300-317 - 33342-087 - 33342-088 - 33342-093 - 33342-094 - 43817-133 - 43817-135 - 51407-679 - 51407-680 - 51407-681 - 51407-682 - 57237-085 - 57237-086 - 57237-087 - 57237-088 - 61919-394 - 61919-656 - 65862-599 - 65862-600 - 65862-625 And 46 more, listed on the interactive page. ## Evidence counts **Recorded assays** 431 **Active assays** 1 ### Active assay types - Screening ## Pharmacologic actions - Serotonin Receptor Agonists Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D017366.html) ## Related records ### Trials (15) - A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache - A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis - A Study to Evaluate the Safety and Tolerability of Rizatriptan for Long Term Treatment of Acute Migraine in Children and Adolescents (MK-0462-086 AM3) - Drug Study in Pediatric Subjects With Migraines (MK0462-083 AM1) - [Efficacy and Safety of Rizatriptan-Naproxen (10/550 mg) in the Acute Treatment of Migraine](https://trialight.com/data/trial/efficacy-and-safety-of-rizatriptan-naproxen-10-550-mg-in-the-70efddef-4813-48a4-864f-4182d7fde312.md) - MK0462 5 mg, Sumatriptan 50 mg, and Placebo Comparison Study (0462-029) - MK0462 in Treatment of Migraine With Recurrence (MK0462-022) - Rizatriptan 5 mg and 10 mg, Sumatriptan 100 mg, and Placebo Comparison Study (0462-030) - Study to Test a Marketed Drug in the Treatment of Menstrual Migraine (0462-071) - Study to Test a Marketed Drug in the Treatment of Menstrual Migraine (0462-072) - Study to Test an Approved Product in the Early Treatment of Migraine (0462-065) - Study to Test an Approved Product in the Early Treatment of Migraine (0462-066) - Study to Test Rizatriptan in the Early Treatment of Acute Migraine (0462-081) - The Effects of Expectation and Knowledge on Rizatriptan and Placebo Treatment of Acute Migraine Headache - Treatment of Multiple Attacks of Acute Migraine (0462-025) ### Approved for (1) - [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) ### In development for (2) - Migraine with aura Phase 3 - Migraine without aura Phase 3 ### Targets (2) - [HTR1B](https://trialight.com/data/target/htr1b-f109dd33-597e-57af-8498-727af113b42b.md) Serotonin 1b (5-HT1b) receptor agonist - [HTR1D](https://trialight.com/data/target/htr1d-8c6c6eaa-650d-574b-b5ed-aa796d90ad80.md) Serotonin 1d (5-HT1d) receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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