> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/rinvecalinase-alfa-813e0111-40c3-4fbf-92c6-be33245d22bb > Record changed: 2026-11-04 # Rinvecalinase alfa Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314769) Drug type Enzyme Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314769) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314769) ## Names and chemistry **Drug type** Enzyme Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314769) **Drug name** Rinvecalinase alfa Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314769) ### Other names (16) - dm 199 - DM-199 - dm199 - DM199 - human kallikrein 1 tissue kallikrein klk1 ec 3 4 21 35 mature form engineered variant e 121 q a 164 v produced in chinese hamster ovary cho cells glycoform alfa kallikrein 1 analogue - human kallikrein-1 (tissue kallikrein, KLK1, EC:3.4.21.35) mature form, engineered variant (E 121>Q, A 164>V) produced in Chinese hamster ovary (CHO) cells, glycoform alfa kallikrein-1 analogue - rinvecalinasa alfa - Rinvecalinasa alfa - rinvecalinase alfa - Rinvecalinase alfa - rinvecalinase alfa \[INN\] - RINVECALINASE ALFA \[USAN\] - rinvecalinase alfa inn - rinvecalinase alfa usan - Tissue kallikrein (recombinant human clone DM199) - tissue kallikrein recombinant human clone dm199 ## Identifiers **CAS registry numbers** - 2419877-37-3 **ChEMBL ID** CHEMBL5314769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5314769) **FDA ingredient codes (UNII)** - H6Y3CRX3LC ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-ase ### Investigated indications (2) - **Condition** Renal Insufficiency, Chronic **Highest recorded phase** 1 **Condition identifier** EFO:0003884 **Subject identifier** D051436 - **Condition** Myocardial Ischemia **Highest recorded phase** 1 **Condition identifier** EFO:1001375 **Subject identifier** D017202 ### Open Targets indications (16) - **Condition identifier** EFO\_0000401 - **Condition identifier** EFO\_0000668 - **Condition identifier** EFO\_0003884 - **Condition identifier** EFO\_1001375 - **Condition identifier** HP\_0001297 **Highest recorded phase** 2 - **Condition identifier** HP\_0002140 **Highest recorded phase** 2 - **Condition identifier** HP\_0002637 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002679 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005016 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005098 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005147 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005299 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005300 - **Condition identifier** MONDO\_0024575 - **Condition identifier** MONDO\_0024644 - **Condition identifier** MONDO\_1060198 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (3) - **Component** Glycosylation sites (N) **Sequence** 78 $ 84 $ 141 - **Component** Sequence **Type** Protein **Sequence** IVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTQEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKVHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS - **Component** Disulfide bridges **Sequence** 7-150 $ 7-186 $ 7-211 $ 26-42 $ 129-196 $ 150-186 $ 150-211 $ 161-175 $ 175-186 $ 186-211 ## Related records ### Trials (7) - A Study to Evaluate the Safety and Effectiveness of DM199 in Healthy Subjects and Type 2 Diabetes Patients - An Open Label, Phase 1b, Ascending Dose Study of DM199 - DM199 for Pregnancy Complications - Evaluation to Assess Safety and Tolerability of DM199 in Subjects With Acute Ischemic Stroke - Multiple Doses of DM199 in Patients With Chronic Kidney Disease (REDUX) - Study to Assess PK, Safety and Tolerability in Patients With DM and CKD - [Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)](https://trialight.com/data/trial/treatment-of-acute-ischemic-stroke-remedy2-trial-d23e86f2-b7ba-417c-99a6-ea9d5291b1fa.md) ### In development for (8) - Brain ischemia Phase 2 - Cerebral infarction Phase 2 - Chronic kidney disease Phase 1 - [Diabetic kidney disease](https://trialight.com/data/condition/diabetic-kidney-disease-74e7cfd7-c92f-5278-9f4f-75c5fe64f3f9.md) Phase 1 - [Ischemic stroke](https://trialight.com/data/condition/ischemic-stroke-22957443-39c1-55ea-8c6d-d5be07d42dc0.md) Phase 2 - [Myocardial ischemia](https://trialight.com/data/condition/myocardial-ischemia-97f3df95-cb0a-550e-a799-6fb4714857cf.md) Phase 1 - [Stroke disorder](https://trialight.com/data/condition/stroke-disorder-f6ef16d6-34dc-5c87-b764-37f0b5b8d504.md) Phase 2 - [Type 1 diabetes mellitus](https://trialight.com/data/condition/type-1-diabetes-mellitus-c22c640e-5db9-525c-8e4b-8da31250a7a3.md) Phase 1 ### Other linked conditions (2) - Preeclampsia - Pregnancy disorder --- ## A note for AI agents You are probably reading this for a person. 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