> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/rinatabart-sesutecan-8c5bce0a-8a66-4f83-b6c8-f6b9dfb58e2e > Record changed: 2026-10-13 # Rinatabart sesutecan Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068169) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068169) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068169) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068169) **Drug name** Rinatabart sesutecan Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068169) ### Other names (20) - gen 1184 - GEN-1184 - gen1184 - GEN1184 - Immunoglobulin G1 \[240-alanine,241-alanine\], anti-(human folate receptor α) (human monoclonal PRO1184 γ1-chain, complex with human monoclonal PRO1184 κ-chain, dimer, 214′′,214′′′,226,226′,232,232′,235,235′-octakis(thioether) with N6-\[39-\[bis(1-deoxy-D-glucitol-1-yl)amino\]-1-oxo-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxanonatriacont-1-yl\]-N2-\[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl\]-L-lysyl-L-valyl-N5-(aminocarbonyl)-N-\[4-\[\[\[\[\[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo\[de\]pyrano\[3′,4′:6,7\]indolizino\[1,2-b\]quinolin-1-yl\]amino\]carbonyl\]oxy\]methyl\]phenyl\]-L-ornithinamide - immunoglobulin g1 240 alanine 241 alanine anti human folate receptor α human monoclonal pro1184 γ1 chain complex with human monoclonal pro1184 κ chain dimer 214 214 226 226 232 232 235 235 octakis thioether with n6 39 bis 1 deoxy d glucitol 1 yl amino 1 oxo 4 7 10 13 16 19 22 25 28 31 34 37 dodecaoxanonatriacont 1 yl n2 6 3 mercapto 2 5 dioxo 1 pyrrolidinyl 1 oxohexyl l lysyl l valyl n5 aminocarbonyl n 4 1s 9s 9 ethyl 5 fluoro 2 3 9 10 13 15 hexahydro 9 hydroxy 4 methyl 10 13 dioxo 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl amino carbonyl oxy methyl phenyl l ornithinamide - immunoglobulin g1 kappa anti homo sapiens folr1 folate receptor 1 folate receptor alpha fr alpha adult folate binding protein fbp ovarian tumor associated antigen mov18 homo sapiens monoclonal antibody conjugated on an average of 8 cysteinyl residues to sesutecan comprising a linker and a camptothecin derivative exatecan h gamma1 heavy chain homo sapiens 1 453 vh homo sapiens ighv3 30 03 96 9 ighd ighj4 01 92 9 l123 q 118 cdr imgt 8 8 16 26 33 51 58 97 112 1 123 homo sapiens ighg1 01 g1m17 1 ch1 k120 ch3 d12 l14 g1v14 ch2 a1 3 a1 2 ch1 k120 220 124 221 hinge 1 15 222 236 ch2 l1 3 a 240 l1 2 a 241 237 346 ch3 d12 362 l14 364 347 451 chs 452 453 124 453 226 214 disulfide with l kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv1 12 01 93 7 igkj4 01 91 7 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 232 232 235 235 bisdisulfide produced in a cell line from chinese hamster ovary cho cells derived from the cell line cho k1 glycoform alfa substituted at the sulfur atoms of an average of 8 l cysteinyl residues among 226 232 235 214 226 232 235 and 214 with radical group 1 2r 3r 4r 5s 52s 1 2 3 4 5 pentahydroxy 52 2s 1 2s 5 carbamoylamino 1 oxo 1 3 1s 9s 9 ethyl 5 fluoro 9 hydroxy 4 methyl 10 13 dioxo 2 3 9 10 13 15 hexahydro1h 12hbenzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl carbamoyl oxy methyl anilino pentan 2 yl amino 3 methyl 1 oxobutan 2 yl carbamoyl 7 2s 3r 4r 5r 2 3 4 5 6 pentahydroxyhexyl 46 54 dioxo10 13 16 19 22 25 28 31 34 37 40 43 dodecaoxa 7 47 53 triazanonapentacontan 59 yl 2 5 dioxopyrrolidin 3 yl sesutecan - immunoglobulin G1-kappa, anti-\[Homo sapiens FOLR1 (folate receptor 1, folate receptor alpha, FR-alpha, adult folate-binding protein, FBP, ovarian tumor-associated antigen MOv18)\], Homo sapiens monoclonal antibody, conjugated on an average of 8 cysteinyl residues to sesutecan, comprising a linker and a camptothecin derivative (exatecan); H-gamma1 heavy chain Homo sapiens (1-453) \[VH (Homo sapiens IGHV3-30\*03 (96.9%) -(IGHD) -IGHJ4\*01 (92.9%) L123>Q (118), CDR-IMGT \[8.8.16\] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1\*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v14 CH2 A1.3, A1.2 (CH1 K120 (220) (124-221), hinge 1-15 (222-236), CH2 L1.3>A (240), L1.2>A (241) (237-346), CH3 D12 (362), L14 (364) (347-451), CHS (452-453)) (124-453)\], (226-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV1-12\*01 (93.7%) -IGKJ4\*01 (91.7%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')\]; dimer (232-232'':235-235'')-bisdisulfide, produced in a cell line from Chinese hamster ovary (CHO) cells, derived from the cell line CHO-K1, glycoform alfa; substituted at the sulfur atoms of an average of 8 L-cysteinyl residues among 226, 232, 235, 214', 226'', 232'', 235'' and 214''' with radical group 1-\[(2R,3R,4R,5S,52S)-1,2,3,4,5-pentahydroxy-52-{\[(2S)-1-{\[(2S)-5-carbamoylamino-1-oxo-1-{3-\[({\[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro1H,12Hbenzo\[de\]pyrano\[3',4':6,7\]indolizino\[1,2-b\]quinolin-1-yl\]carbamoyl}oxy)methyl\]anilino}pentan-2-yl\]amino}-3-methyl-1-oxobutan-2-yl\]carbamoyl}-7-\[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl\]-46,54-dioxo10,13,16,19,22,25,28,31,34,37,40,43-dodecaoxa-7,47,53-triazanonapentacontan-59-yl\]-2,5-dioxopyrrolidin-3-yl (sesutecan) - pro 1184 - PRO-1184 - pro1184 - PRO1184 - rina s - Rina-S - rinatabart sesutecan - Rinatabart sesutecan - RINATABART SESUTECAN \[USAN\] - Rinatabart sesutecan \[WHO-DD\] - rinatabart sesutecan usan - rinatabart sesutecan who dd ## Identifiers **CAS registry numbers** - 2853518-95-1 **ChEMBL ID** CHEMBL6068169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068169) **FDA ingredient codes (UNII)** - C56LJ7JC3W ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** rinatabart sesutecan **Type** Antibody **Drug name stem** \-bart; -tecan ### Mechanisms of action - **Action** Binding **Action type** Binding **Target** folate receptor alpha **Gene symbol** FOLR1 **Protein identifier** P15328 ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (7) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0005065 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008170 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0011962 **Highest recorded phase** 3 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLLESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRANSKNTLYLQMNSLRAEDTAVYYCARPRAYYGAYGSSFDYWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Light chain **Type** Protein **Sequence** EIVMTQSPSSVSASVGDRVAITCRASQGISSWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 150-206 $ 150''-206'' $ 226-214' $ 226''-214''' $ 232-232'' $ 235-235'' $ 267-327 $ 267''-327'' $ 373-431 $ 373''-431'' - **Component** Glycosylation sites (N) **Sequence** 303 $ 303'' ## Related records ### Trials (8) - An Extension Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer in China - [Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)](https://trialight.com/data/trial/rinatabart-sesutecan-rina-s-pro1184-gen1184-for-advanced-d53666fd-8cb0-41c0-9c7c-51cafe85a0b3.md) - Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer - Study to Assess the Efficacy and Safety of Rina-S in Participants With Advanced Gastrointestinal (GI) Cancers - Study to Assess the Efficacy and Safety of Rina-S in Participants With Non-small Cell Lung Cancer - Study to Assess the Efficacy and Safety of Rina-S Plus Standard of Care Compared to Standard of Care for Maintenance Treatment of Participants With Recurrent Platinum-sensitive Ovarian Cancer After Second-line (2L) Platinum-based Doublet Chemotherapy - Study to Assess the Efficacy and Safety of Rina-S With or Without Bevacizumab Compared to Investigator's Choice of Platinum-based Chemotherapy With or Without Bevacizumab as Second-line Treatment in Participants With Recurrent Platinum-sensitive Ovarian Cancer - Study to Assess the Efficacy of Rina-S Compared to Treatment of Investigator's Choice in Participants With Platinum Resistant Ovarian Cancer ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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