> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/rimegepant-c1207159-0a84-4344-9a8d-b5dc577a317a > Record changed: 2026-11-04 # Rimegepant Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) First approval year 2020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) ## Development status **First approval year** 2020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) **Drug name** Rimegepant Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) **Molecular weight** 534.57 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) **Structure (SMILES)** N\[C@@H\]1c2cccnc2\[C@H\](OC(=O)N2CCC(n3c(=O)\[nH\]c4ncccc43)CC2)CC\[C@H\]1c1cccc(F)c1F Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) ### Other names (16) - bhv 3000 - Bhv-3000 - bms 927711 - bms 927711 cgrp antagonist - BMS-927711 - BMS-927711 (CGRP Antagonist) - rimegepant - Rimegepant - Rimegepant \[INN\] - Rimegepant \[MI\] - Rimegepant \[USAN\] - Rimegepant \[WHO-DD\] - rimegepant inn - rimegepant mi - rimegepant usan - rimegepant who dd ## Identifiers **ATC classification codes** - N02CD06 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) **CAS registry numbers** - 1289023-67-1 **ChEMBL ID** CHEMBL2178422 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) **InChIKey** KRNAOFGYEFKHPB-ANJVHQHFSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2178422) **PubChem compound IDs** - 51049968 **RxNorm IDs (RxCUI)** - 2282307 **FDA ingredient codes (UNII)** - 997WVV895X ## Regulatory information ### United States **Applicant** PFIZER **Approval date** 27 Feb 2020 **Application number** NDA212728 ### European Union **Status** Authorised **Status date** 25 Apr 2022 **Authorisation date** 25 Apr 2022 **Approved indications** Vydura is indicated for the Acute treatment of migraine with or without aura in adults; Preventative treatment of episodic migraine in adults who have at least 4 migraine attacks per month. **Product number** EMEA/H/C/005725 **Authorisation holder** Pfizer Europe MA EEIG **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** Yes **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Migraine Disorders European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/vydura) ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Approval status **United States (FDA)** Approved **European Union (EMA)** Authorised ## Pharmacology ### Drug classification **Pharmacology name** rimegepant **Type** Synthetic organic **Drug name stem** \-gepant **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Oral ### Mechanisms of action (5) - **Action** Antagonist **Action type** Antagonist **Target** AMY1 receptor **Gene symbol** RAMP1 **Protein identifier** O60894 **Median affinity** 8.1 **Affinity units** pKB - **Action** Antagonist **Action type** Antagonist **Target** CGRP receptor **Gene symbol** RAMP1 **Protein identifier** O60894 **Median affinity** 9.6 **Affinity units** pKB **Primary target** Yes - **Action** Antagonist **Action type** Antagonist **Target** AMY1 receptor **Gene symbol** CALCR **Protein identifier** P30988 **Median affinity** 8.1 **Affinity units** pKB - **Action** Antagonist **Action type** Antagonist **Target** CGRP receptor **Gene symbol** CALCRL **Protein identifier** Q16602 **Median affinity** 9.6 **Affinity units** pKB **Primary target** Yes - **Mechanism** Calcitonin gene-related peptide type 1 receptor antagonist **Action type** Antagonist **Target** Calcitonin gene-related peptide type 1 receptor **Protein identifier** Q16602 ### Open Targets mechanisms - **Mechanism** Calcitonin gene-related peptide type 1 receptor antagonist **Action type** Antagonist **Target** Calcitonin gene-related peptide type 1 receptor ### DrugCentral mechanisms - **Action type** Antagonist **Gene symbol** CALCRL **Protein identifier** Q16602 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (7) - **Condition** Irritable Bowel Syndrome **Highest recorded phase** 2 **Condition identifier** EFO:0000555 **Subject identifier** D043183 - **Condition** Psoriasis **Highest recorded phase** 2 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Pain **Highest recorded phase** 2 **Condition identifier** EFO:0003843 **Subject identifier** D010146 - **Condition** Temporomandibular Joint Disorders **Highest recorded phase** 3 **Condition identifier** EFO:0005279 **Subject identifier** D013705 - **Condition** Sinusitis **Highest recorded phase** 3 **Condition identifier** EFO:0007486 **Subject identifier** D012852 - **Condition** Trigeminal Neuralgia **Highest recorded phase** 2 **Condition identifier** EFO:1001219 **Subject identifier** D014277 - **Condition** Migraine Disorders **Highest recorded phase** 3 **Condition identifier** MONDO:0005277 **Subject identifier** D008881 ### Open Targets indications (19) - **Condition identifier** EFO\_0000555 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000676 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005279 **Highest recorded phase** 3 - **Condition identifier** EFO\_0007486 **Highest recorded phase** 3 - **Condition identifier** EFO\_0008008 - **Condition identifier** EFO\_1001219 **Highest recorded phase** 2 - **Condition identifier** HP\_0002027 **Highest recorded phase** 2 - **Condition identifier** HP\_0012531 **Highest recorded phase** 2 - **Condition identifier** HP\_0100582 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005052 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005184 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005277 - **Condition identifier** MONDO\_0005277 **Highest recorded phase** 4 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006031 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0006314 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0008599 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0021040 **Highest recorded phase** 1 ### Reported adverse events (2) - **Event** decreased embryo viability **Reports** 1 **Reporting signal score** 11.3267 - **Event** drug interaction **Reports** 3 **Reporting signal score** 9.57925 ### Trial references (21) - NCT01430442 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01430442) - NCT01445067 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01445067) - NCT03235479 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03235479) - NCT03237845 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03237845) - NCT03266588 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03266588) - NCT03461757 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03461757) - NCT03732638 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03732638) - NCT04574362 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04574362) - NCT04649242 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04649242) - NCT04743141 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04743141) - NCT05156398 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05156398) - NCT05371652 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05371652) - NCT05399459 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05399459) - NCT05399485 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05399485) - NCT05810038 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05810038) - NCT03941834 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03941834) - NCT04629950 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04629950) - NCT05248997 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05248997) - NCT05262517 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05262517) - NCT05264714 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05264714) - NCT06221111 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06221111) ## Dosing **Dose** 75 mg **Route** Oral **How often** As needed; every other day ### Conditions of use - Take with or without food ## Chemical properties **Hydrogen bond acceptors** 7 **Hydrogen bond donors** 2 **Polar surface area** 119.13 **Calculated partition coefficient (ALogP)** 4.49 **Calculated partition coefficient (XLogP)** 2.3 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 3 **Heavy atoms** 39 **Molecular formula** C28H28F2N6O3 **Monoisotopic mass** 534.21909510 **Natural product** No ## Evidence counts **Recorded assays** 1,171 **Active assays** 7 ### Active assay types - Confirmatory ## Biological measurements These details could not be displayed. ## Related records ### Trials (61) - A Clinical Trial of Rimegepant for Vestibular Migraine Evaluation: Pre-experiment - A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache - A Prospective Real World Study of Rimegepant in the Treatment of Migraine - A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department - A Randomized, Open-Label, Multi-Center Study of Vestibular Migraine Prevention: Rimegepant Versus Flunarizine Non-inferiority Study - A Registry Study on Rimegepant for the Treatment of Migraine Participants in Guangdong-Hong Kong-Macao Greater Bay Area - A Study of Galcanezumab (LY2951742) in Adult Participants With Episodic Migraine - A Study to Find Out if the Medicine Called Rimegepant is Safe for Adults in India - A Study to Learn About the Long-term Safety of Rimegepant for the Acute Treatment of Migraine in Chinese Participants - A Study to Learn About the Safety and Effects of Rimegepant to Prevent Migraine in Chinese Subjects. - A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine - A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine - A Study to Learn About the Study Medicine Called Rimegepant in Adults When Used for the Prevention of Chronic Migraine - A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine - Acute Migraine Treatment in the ED With Gepants - An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache - An Open-label, Intermediate Size, Expanded Access Study of BHV-3000 in the Acute Treatment of Migraine - ARISE-A Chinese Real-world Study of Rimegepant for the Acute Treatment of Migraine - Biological Profiles of Neuropeptides, Neurotrophins and miRNA in Migraine - Cluster Headache Treatment With Rimegepant ### In development for (12) - Chronic rhinosinusitis Phase 3 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 2 - [Irritable bowel syndrome](https://trialight.com/data/condition/irritable-bowel-syndrome-10830a51-118b-59c5-8ff4-5e11dbe81c01.md) Phase 2 - [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 1 - [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) Phase 3 - Nasal cavity polyp Phase 3 - [Pancreatic ductal adenocarcinoma](https://trialight.com/data/condition/pancreatic-ductal-adenocarcinoma-77c1c5a8-638b-51d0-b18e-2c881b8902e5.md) Phase 1 - [Pancreatic neoplasm](https://trialight.com/data/condition/pancreatic-neoplasm-de300cc3-339a-5c06-97d8-2d9155fc3a7b.md) Phase 1 - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 2 - [Sinusitis](https://trialight.com/data/condition/sinusitis-2103c563-991f-52d7-b411-a1402fd4cbe6.md) Phase 3 - Temporomandibular joint disorder Phase 3 - Trigeminal neuralgia Phase 2 ### Targets (3) - [CALCR](https://trialight.com/data/target/calcr-087bb7fb-7962-554a-a552-307e1328bfbc.md) - [CALCRL](https://trialight.com/data/target/calcrl-ab682234-2bfa-51bd-a9eb-e0d3e9a4ee16.md) Calcitonin gene-related peptide type 1 receptor antagonist - [RAMP1](https://trialight.com/data/target/ramp1-304d5657-b31c-5ac4-bfab-a6382a086a28.md) --- ## A note for AI agents You are probably reading this for a person. 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