> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/rezpegaldesleukin-e59e4dbf-5d1e-4fba-ba17-2fa0fc44cdde > Record changed: 2026-10-13 # Rezpegaldesleukin Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095458) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095458) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095458) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095458) **Drug name** Rezpegaldesleukin Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095458) ### Other names (22) - il 2 peg conjugate nktr 358 - Il-2 peg conjugate (nktr-358) - INTERLEUKIN 2 (DE-1-ALANINE,125-SERINE) (RECOMBINANT HUMAN), N6-(4-(2-((((2-HYDROXYETHYL)AMINO)CARBONYL)OXY)-1-(((((2-HYDROXYETHYL)AMINO)CARBONYL)OXY) METHYL)ETHOXY)-1-OXOBUTYL)-L-LYSINE DIETHER WITH .ALPHA.-HYDRO-.OMEGA.-METHOXYPOLY(OXY-1,2-ETHANEDIYL) - interleukin 2 de 1 alanine 125 serine recombinant human n6 4 2 2 hydroxyethyl amino carbonyl oxy 1 2 hydroxyethyl amino carbonyl oxy methyl ethoxy 1 oxobutyl l lysine diether with alpha hydro omega methoxypoly oxy 1 2 ethanediyl - ly 3471851 - LY-3471851 - ly3471851 - LY3471851 - nktr 358 - NKTR-358 - rezpegaldesleukin - Rezpegaldesleukin - rezpegaldesleukin \[INN\] - REZPEGALDESLEUKIN \[USAN\] - Rezpegaldesleukin \[WHO-DD\] - rezpegaldesleukin inn - rezpegaldesleukin usan - rezpegaldesleukin who dd - rezpegaldesleukina - Rezpegaldesleukina - rezpegaldesleukine - Rezpegaldesleukine ## Identifiers **CAS registry numbers** - 2641686-76-0 **ChEMBL ID** CHEMBL5095458 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095458) **FDA ingredient codes (UNII)** - VGR86P26ER ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-kin; -peg- ### Investigated indications (6) - **Condition** Dermatitis, Atopic **Highest recorded phase** 2 **Condition identifier** EFO:0000274 **Subject identifier** D003876 - **Condition** Psoriasis **Highest recorded phase** 1 **Condition identifier** EFO:0000676 **Subject identifier** D011565 - **Condition** Colitis, Ulcerative **Highest recorded phase** 2 **Condition identifier** EFO:0000729 **Subject identifier** D003093 - **Condition** Alopecia Areata **Highest recorded phase** 2 **Condition identifier** EFO:0004192 **Subject identifier** D000506 - **Condition** Autoimmune Diseases **Highest recorded phase** 1 **Condition identifier** EFO:0005809 **Subject identifier** D001327 - **Condition** Lupus Erythematosus, Systemic **Highest recorded phase** 1 **Condition identifier** MONDO:0007915 **Subject identifier** D008180 ### Open Targets indications (12) - **Condition identifier** EFO\_0000274 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000676 **Highest recorded phase** 1 - **Condition identifier** EFO\_0000729 **Highest recorded phase** 2 - **Condition identifier** EFO\_0004192 **Highest recorded phase** 2 - **Condition identifier** EFO\_0005809 - **Condition identifier** MONDO\_0004980 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005083 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005101 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005147 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005340 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007179 - **Condition identifier** MONDO\_0007915 **Highest recorded phase** 2 ### Trial references (5) - NCT03556007 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03556007) - NCT04119557 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04119557) - NCT04677179 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04677179) - NCT06136741 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06136741) - NCT06340360 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06340360) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (2) - **Component** Sequence **Type** Protein **Sequence** PTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFSQSIISTLT - **Component** Disulfide bridges **Sequence** 57-104 ## Related records ### Trials (14) - [A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis](https://trialight.com/data/trial/a-phase-2b-study-to-evaluate-rezpegaldesleukin-rezpeg-in-the-895acd6f-de64-40f6-9abe-d218203c0670.md) - A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Severe to Very Severe Alopecia Areata in Adult Patients (Rezolve AA) - A Phase 3 Study of Rezpegaldesleukin (NKTR-358) for Patients ≥ 12 Years of Age With Moderate-to-Severe Atopic Dermatitis - A Phase 3 Study of Rezpegaldesleukin (NKTR-358) for Patients ≥ 12 Years of Age With Moderate-to-Severe Atopic Dermatitis - A Phase I Study of LY3471851 in Healthy Participants - A Single-Dose Study of LY3471851 in Healthy Participants - A Study of LY3471851 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC) - A Study of LY3471851 in Adults With Systemic Lupus Erythematosus (SLE) - A Study of LY3471851 in Healthy Participants - A Study of LY3471851 in Participants With Eczema - A Study of LY3471851 in Participants With Psoriasis - A Study of NKTR-358 (LY3471851) in Healthy Participants - A Study of NKTR-358 (LY3471851) in Participants With Systemic Lupus Erythematosus (SLE) - Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus ### In development for (7) - [Alopecia areata](https://trialight.com/data/condition/alopecia-areata-8709d8ab-db3b-57e6-88fa-7d7ae93d4561.md) Phase 2 - [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md) Phase 2 - [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) Phase 1 - [Psoriasis](https://trialight.com/data/condition/psoriasis-4340caf0-883c-54c7-886d-31e59b80dead.md) Phase 1 - [Systemic lupus erythematosus](https://trialight.com/data/condition/systemic-lupus-erythematosus-6c9d074f-cc5f-588b-bf0c-6338d30c6eac.md) Phase 1 - Type 1 diabetes mellitus Phase 2 - [Ulcerative colitis](https://trialight.com/data/condition/ulcerative-colitis-afbc4579-f001-5a8a-b904-28f09f344ab5.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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