> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/retlirafusp-alfa-896e1516-969b-421a-8f63-2b8ae4836dff > Record changed: 2026-10-29 # Retlirafusp alfa Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095383) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095383) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095383) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095383) **Drug name** Retlirafusp alfa Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095383) ### Other names (19) - drug retlirafusp alfa - Drug: Retlirafusp alfa - IMMUNOGLOBULIN G4 (52-GLYCINE, 57-PHENYLALANINE, 227-PROLINE, 233-ALANINE, 234-ALANINE, 446-ALANINE), ANTI-(HUMAN PROGRAMMED DEATH-LIGAND 1) (HUMAN-MUS MUSCULUS MONOCLONAL SHR-1316 .GAMMA.4-CHAIN) FUSION PROTEIN WITH PEPTIDE LINKER ((GGGGS)4G) FUSION PROTEIN WITH 20-136-TYPE II TRANSFORMING GROWTH FACTOR .BETA. RECEPTOR (HUMAN ISOFORM 1), DISULFIDE WITH (85-GLUTAMIC ACID) HUMAN-MUS MUSCULUS MONOCLONAL SHR-1316 .KAPPA.-CHAIN, DIMER - immunoglobulin g4 52 glycine 57 phenylalanine 227 proline 233 alanine 234 alanine 446 alanine anti human programmed death ligand 1 human mus musculus monoclonal shr 1316 gamma 4 chain fusion protein with peptide linker ggggs 4g fusion protein with 20 136 type ii transforming growth factor beta receptor human isoform 1 disulfide with 85 glutamic acid human mus musculus monoclonal shr 1316 kappa chain dimer - retlirafusp alfa - Retlirafusp alfa - Retlirafusp Alfa - retlirafusp alfa \[INN\] - Retlirafusp alfa \[WHO-DD\] - Retlirafusp alfa Injection - retlirafusp alfa inn - retlirafusp alfa who dd - shr 1701 - Shr 1701 - SHR-1701 - SHR-1701 injection - SHR-1701 Injection - shr1701 - SHR1701 ## Identifiers **CAS registry numbers** - 2395839-91-3 **ChEMBL ID** CHEMBL5095383 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095383) **FDA ingredient codes (UNII)** - JP6N6TA92L ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** retlirafusp alfa **Type** Antibody **Drug name stem** \-fusp **Approval recorded by Guide to Pharmacology** Yes ### Mechanisms of action (2) - **Action** Binding **Action type** Binding **Target** programmed cell death 1 ligand 1 **Gene symbol** programmed cell death 1 ligand 1 - **Action** Binding **Action type** Binding **Target** TGFβ3 **Gene symbol** TGFβ3 ### Investigated indications (10) - **Condition** Carcinoma, Squamous Cell **Highest recorded phase** 2 **Condition identifier** EFO:0000181 **Subject identifier** D002294 - **Condition** Hodgkin Disease **Highest recorded phase** 1 **Condition identifier** EFO:0000183 **Subject identifier** D006689 - **Condition** Lymphoma **Highest recorded phase** 1 **Condition identifier** EFO:0000574 **Subject identifier** D008223 - **Condition** Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Melanoma **Highest recorded phase** 2 **Condition identifier** EFO:0000756 **Subject identifier** D008545 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 1 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Carcinoma, Non-Small-Cell Lung **Highest recorded phase** 3 **Condition identifier** EFO:0003060 **Subject identifier** D002289 - **Condition** Breast Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0007254 **Subject identifier** D001943 - **Condition** Lung Neoplasms **Highest recorded phase** 2 **Condition identifier** MONDO:0008903 **Subject identifier** D008175 - **Condition** Nasopharyngeal Carcinoma **Highest recorded phase** 1 **Condition identifier** MONDO:0015459 **Subject identifier** D000077274 ### Open Targets indications (32) - **Condition identifier** EFO\_0000181 **Highest recorded phase** 2 - **Condition identifier** EFO\_0000183 - **Condition identifier** EFO\_0000574 - **Condition identifier** EFO\_0000616 - **Condition identifier** EFO\_0002618 - **Condition identifier** EFO\_0003060 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0000544 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0002974 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0003210 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0003219 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0004992 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005008 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005036 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005070 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005097 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005105 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005192 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005580 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006519 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007254 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0007256 - **Condition identifier** MONDO\_0008170 **Highest recorded phase** 2 And 7 more, listed on the interactive page. ### Trial references (19) - NCT03710265 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03710265) - NCT03774979 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03774979) - NCT04324814 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04324814) - NCT04679038 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04679038) - NCT04282070 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04282070) - NCT05020925 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05020925) - NCT04355858 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04355858) - NCT04407741 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04407741) - NCT04560244 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04560244) - NCT04580498 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04580498) - NCT04699968 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04699968) - NCT04937972 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04937972) - NCT05132413 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05132413) - NCT05177497 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05177497) - NCT04624217 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04624217) - NCT04650633 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04650633) - NCT04884009 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04884009) - NCT05106023 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05106023) - NCT05896046 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05896046) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ## Related records ### Trials (64) - A Clinical Study of SHR-1701 Combined With Chemotherapy for the Perioperative Treatment of Locally Advanced Resectable Siewert Type II Adenocarcinoma of the Esophagogastric Junction - A Clinical Studyf of SHR-1701 or Placebo in Combination With BP102 and XELOX in the First-line Treatment of mCRC - A Phase I Study of HRS2300 or Combined With SHR-1316 or SHR-1701 or Trametinib or Almonertinib in Patients With Advanced Malignancies - A Randomized, Open-label, Double-cohort Study of Fluzoparib Combined With Famitinib Malate or SHR-1701 for Neoadjuvant Therapy in Patients With Advanced Ovarian Cancer - A Study of SHR-1701 Plus Bevacizumab and Chemotherapy in Non-Small-Cell-Lung-Cancer - A Study of SHR-1701 Plus Platinum-containing Chemotherapy With or Without BP102 (Bevacizumab) as First-line Treatment in Cervical Cancer - A Trial of SHR-1701 in Combination With and Without Famitinib Malate in Patients With Extensive Stage Small Cell Lung Cancer - A Trial of SHR-1701 in Combination With Famitinib in Patients With Advanced Solid Tumors - A Trial of SHR-1701 in Combination With Gemcitabine and Albumin Paclitaxel in Patients With Pancreatic Cancer - A Trial of SHR-1701 in Subjects With Advanced Solid Tumors - A Trial of SHR-1701 With or Without Chemotherapy in Patients With Stage III NSCLC - A Trial of SHR-1701 With or Without Famitinib in Patients With Advanced or Metastatic NSCLC - [A Trial of SHR-2002 Injection or Combined With Other Anti-cancer Medication in Advanced Malignant Tumors of Patients](https://trialight.com/data/trial/a-trial-of-shr-2002-injection-or-combined-with-other-anti-9b204cad-ba32-4d65-ab31-9b8c11a07c73.md) - A Trial of SHR1701 Combined With Radiotherapy for Metastatic Non-small Cell Lung Cancer Failure After First-line Treatment - A Trial of SHR1701 Plus Chemotherapy in Patients With Gastric or Gastroesophageal Cancer - Adebrelimab or Retlirafusp Alfa Plus Recaticimab and Chemotherapy for Resectable NSCLC - An Exploratory Clinical Study of Accurate Efficacy Assessment of Neoadjuvant Immunotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma Based on 68Ga-FAPI (\[68Ga\] Fibroblast Activation Protein Inhibitor)/¹⁸F-FDG (2-Deoxy-2-\[¹⁸F\]Fluoro-D-glucose) Dual Imaging - An Umbrella-designed Prospective Multicenter Randomized Open-label Superiority Trial Evaluating Multi-biomarker-guided Precision Therapy for First-line Treatment of Advanced Esophageal Squamous Cell Carcinoma - Chemoradiotherapy and SHR-1701 in Patients With Unresectable Gastric Cancer - Clinical Study of SHR-1701 Plus Chemotherapy as Perioperative Treatment in Subjects With Gastric Cancer ### In development for (10) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2 - Exocrine pancreatic carcinoma Phase 1 - [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 2 - Hodgkins lymphoma Phase 1 - [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 2 - [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 1 - [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 2 - [Nasopharyngeal carcinoma](https://trialight.com/data/condition/nasopharyngeal-carcinoma-9ead4a97-f794-5dda-b62e-20f8ca202f89.md) Phase 1 - Neoplasm Phase 1 - [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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