> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/retatrutide-1c18d390-804a-469b-95a1-d654ddcca41e
> Record changed: 2026-10-13

# Retatrutide

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095485)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095485)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095485)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095485)

**Drug name**

Retatrutide

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095485)

### Other names (13)

- ly 3437943
- LY-3437943
- ly3437943
- LY3437943
- retatrutide
- Retatrutide
- Retatrutide (LY3437943)
- retatrutide \[INN\]
- RETATRUTIDE \[USAN\]
- Retatrutide \[WHO-DD\]
- retatrutide inn
- retatrutide usan
- retatrutide who dd

## Identifiers

**CAS registry numbers**

- 2381089-83-2

**ChEMBL ID**

CHEMBL5095485

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095485)

**RxNorm IDs (RxCUI)**

- 2722410

**FDA ingredient codes (UNII)**

- NOP2Y096GV

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

retatrutide

**Type**

Peptide

**Drug name stem**

\-tide

### Mechanisms of action (6)

- **Mechanism**  
Gastric inhibitory polypeptide receptor agonist

**Action type**  
Agonist

**Target**  
Gastric inhibitory polypeptide receptor

**Protein identifier**  
P48546
- **Mechanism**  
Glucagon receptor agonist

**Action type**  
Agonist

**Target**  
Glucagon receptor

**Protein identifier**  
P47871
- **Mechanism**  
Glucagon-like peptide 1 receptor agonist

**Action type**  
Agonist

**Target**  
Glucagon-like peptide 1 receptor

**Protein identifier**  
P43220
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
GLP-1 receptor

**Gene symbol**  
GLP1R

**Protein identifier**  
P43220

**Median affinity**

8.14

**Affinity units**  
pKi
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
glucagon receptor

**Gene symbol**  
GCGR

**Protein identifier**  
P47871

**Median affinity**

8.25

**Affinity units**  
pKi
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
GIP receptor

**Gene symbol**  
GIPR

**Protein identifier**  
P48546

**Median affinity**

10.24

**Affinity units**  
pKi

### Open Targets mechanisms (3)

- **Mechanism**  
Gastric inhibitory polypeptide receptor agonist

**Action type**  
Agonist

**Target**  
Gastric inhibitory polypeptide receptor
- **Mechanism**  
Glucagon receptor agonist

**Action type**  
Agonist

**Target**  
Glucagon receptor
- **Mechanism**  
Glucagon-like peptide 1 receptor agonist

**Action type**  
Agonist

**Target**  
Glucagon-like peptide 1 receptor

### Investigated indications (4)

- **Condition**  
Diabetes Mellitus

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000400

**Subject identifier**  
D003920
- **Condition**  
Obesity

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001073

**Subject identifier**  
D009765
- **Condition**  
Renal Insufficiency

**Highest recorded phase**  
1

**Condition identifier**  
HP:0000083

**Subject identifier**  
D051437
- **Condition**  
Diabetes Mellitus, Type 2

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005148

**Subject identifier**  
D003924

### Open Targets indications (13)

- **Condition identifier**  
EFO\_0000400

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0001073

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000083

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001399

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0001513

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0001943

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0025502

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004995

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005015
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005178

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005300

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0011122

**Highest recorded phase**  
3

### Trial references (12)

- NCT04143802  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04143802)
- NCT04823208  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04823208)
- NCT04867785  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04867785)
- NCT06260722  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06260722)
- NCT06297603  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06297603)
- NCT04881760  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04881760)
- NCT05445232  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05445232)
- NCT05548231  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05548231)
- NCT06039826  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06039826)
- NCT06383390  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06383390)
- NCT05611957  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05611957)
- NCT06354660  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06354660)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (2)

- **Component**  
Sequence

**Type**  
Protein

**Sequence**  
YA1QGTFTSDYSIL2LDKK4AQA1AFIEYLLEGGPSSGAPPPS3
- **Component**  
Modified residues

**Sequence**  
A1(SMILES):CNC(C)(C)C(C)=O

## Related records

### Trials (34)

- A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants
- [A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)](https://trialight.com/data/trial/a-master-protocol-of-multiple-agents-in-adults-with-e6b397f9-90a9-42e3-81a6-c73e9176a43c.md)
- A Research Study Looking at Similarity Between LY3437943 Versions for Different Injection Devices
- A Safety Study of LY3437943 Given as a Single Injection in Healthy Participants
- A Study of Carbon-14-Labelled \[14C\] LY3437943 in Healthy Male Participants
- A Study of LY3437943 in Chinese Participants With Obesity Or Overweight
- A Study of LY3437943 in Healthy Participants and Participants With Impaired Renal Function
- A Study of LY3437943 in Healthy Participants With a High Body Mass Index
- A Study of LY3437943 in Japanese Participants With Type 2 Diabetes Mellitus (T2DM)
- A Study of LY3437943 in Participants Who Have Obesity or Are Overweight
- A Study of LY3437943 in Participants With Impaired and Normal Liver Function
- A Study of LY3437943 in Participants With Type 2 Diabetes
- A Study of LY3437943 in Participants With Type 2 Diabetes Mellitus (T2DM)
- A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or Obese
- A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
- [A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight](https://trialight.com/data/trial/a-study-of-retatrutide-ly3437943-in-participants-who-have-15265fcb-acc6-4c96-80a5-06c8a4f74049.md)
- A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
- A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
- A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
- [A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight](https://trialight.com/data/trial/a-study-of-retatrutide-ly3437943-in-participants-with-type-2-b440df9f-06ca-4617-9f30-0ebb26f70945.md)

### In development for (4)

- [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) Phase 3
- [Kidney failure](https://trialight.com/data/condition/kidney-failure-f26737b4-3a55-50be-b6c3-b76514cb5067.md) Phase 1
- [Obesity disorder](https://trialight.com/data/condition/obesity-disorder-f3b57dc0-68ac-555c-8f13-0d81e595d9cb.md) Phase 3
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 3

### Targets (3)

- [GCGR](https://trialight.com/data/target/gcgr-418174f7-cf4a-56a4-9273-4cd98d0bc903.md) Glucagon receptor agonist
- [GIPR](https://trialight.com/data/target/gipr-5b65dd73-9875-5aca-be7a-5469a7290f0c.md) Gastric inhibitory polypeptide receptor agonist
- [GLP1R](https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742.md) Glucagon-like peptide 1 receptor agonist

---

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