> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/remternetug-0f80e1d8-0150-48c9-9d21-e10ca6534e7b > Record changed: 2026-10-13 # Remternetug Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095484) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095484) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095484) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095484) **Drug name** Remternetug Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095484) ### Other names (14) - Immunoglobulin G1 \[de-452-lysine\], anti-(human \[3-pyroglutamyl\] β-amyloid) (human monoclonal LY3372993 γ1-chain), disulfide with human monoclonal LY3372993 κ-chain, dimer - immunoglobulin g1 de 452 lysine anti human 3 pyroglutamyl β amyloid human monoclonal ly3372993 γ1 chain disulfide with human monoclonal ly3372993 κ chain dimer - ly 3372993 - LY-3372993 - ly3372993 - LY3372993 - remternetug - Remternetug - Remternetug (Reference) - Remternetug (Test) - remternetug \[INN\] - REMTERNETUG \[USAN\] - remternetug inn - remternetug usan ## Identifiers **CAS registry numbers** - 2571940-41-3 **ChEMBL ID** CHEMBL5095484 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095484) **FDA ingredient codes (UNII)** - A5HTA4J6ME ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications - **Condition** Alzheimer Disease **Highest recorded phase** 3 **Condition identifier** MONDO:0004975 **Subject identifier** D000544 ### Open Targets indications - **Condition identifier** MONDO\_0004975 **Highest recorded phase** 3 ### Trial references (3) - NCT03720548 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03720548) - NCT04451408 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04451408) - NCT05463731 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05463731) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (5) - **Component** Heavy chain **Type** Protein **Sequence** EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYPMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAREGGSGSYYNGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSTLSASVGDRVTITCRASQSLGNWLAWYQQKPGKAPKLLIYQASTLESGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQHYKGSFWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 302 $ 302'''' - **Component** Glycosylation sites (N) **Sequence** 302 $ 302'' - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 149-205 $ 149''-205'' $ 214'-225 $ 214'''-225'' $ 231-231'' $ 234-234'' $ 266-326 $ 266''-326'' $ 372-430 $ 372''-430'' ## Related records ### Trials (8) - A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation - A Study of LY3372993 in Healthy Participants and Participants With Alzheimer's Disease (AD) - A Study of LY3372993 in Participants With Alzheimer's Disease (AD) and Healthy Participants - A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation - [A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)](https://trialight.com/data/trial/a-study-of-remternetug-ly3372993-in-early-alzheimer-s-7df4f973-b394-4b9b-9095-9d17f2111da9.md) - A Study of Remternetug (LY3372993) in Healthy Chinese Participants - A Study of Remternetug (LY3372993) in Healthy Participants - [A Study of Remternetug (LY3372993) in Participants With Alzheimer's Disease (TRAILRUNNER-ALZ 1)](https://trialight.com/data/trial/a-study-of-remternetug-ly3372993-in-participants-with-969b60bd-0231-461d-bc6d-4479e22dc4ed.md) ### In development for (1) - [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 3 --- ## A note for AI agents You are probably reading this for a person. 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