> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/relatlimab-7c233520-282a-4920-8915-6376595bb1af
> Record changed: 2026-10-13

# Relatlimab

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990044)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990044)

First approval year

2022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990044)

## Development status

**First approval year**

2022

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990044)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990044)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990044)

**Drug name**

Relatlimab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990044)

### Brand names (4)

- relatlimab component of bms 986213
- Relatlimab component of bms-986213
- Relatlimab component of opdualag -rmbw
- relatlimab component of opdualag rmbw

### Other names (21)

- bms 986016
- bms 986213 component relatlimab
- BMS-986016
- BMS-986213 COMPONENT RELATLIMAB
- opdualag component relatlimab rmbw
- OPDUALAG COMPONENT RELATLIMAB-RMBW
- relatlimab
- Relatlimab
- relatlimab \[INN\]
- Relatlimab \[MI\]
- RELATLIMAB \[USAN\]
- Relatlimab \[WHO-DD\]
- relatlimab inn
- relatlimab mi
- relatlimab rmbw
- Relatlimab rmbw
- Relatlimab rmbw \[WHO-DD\]
- relatlimab rmbw who dd
- relatlimab usan
- relatlimab who dd
- Relatlimab-rmbw

## Identifiers

**CAS registry numbers**

- 1673516-98-7

**ChEMBL ID**

CHEMBL3990044

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3990044)

**FDA ingredient codes (UNII)**

- AF75XOF6W3

### RxNorm IDs (RxCUI) (2)

- 2596772
- 2596773

## Regulatory information

### United States

**Applicant**

BRISTOL MYERS SQUIBB

**Approval date**

18 Mar 2022

**Application number**

BLA761234

### Other regulatory facts

**First in class**

Yes

**Orphan designation**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

relatlimab

**Type**

Antibody

**Drug name stem**

\-mab

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Parenteral

### Mechanisms of action (2)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
LAG3 (CD223)

**Gene symbol**  
LAG3

**Protein identifier**  
P18627

**Primary target**  
Yes
- **Mechanism**  
Lymphocyte activation gene 3 protein inhibitor

**Action type**  
Inhibitor

**Target**  
Lymphocyte activation gene 3 protein

**Protein identifier**  
P18627

### Open Targets mechanisms

- **Mechanism**  
Lymphocyte activation gene 3 protein inhibitor

**Action type**  
Inhibitor

**Target**  
Lymphocyte activation gene 3 protein

### Investigated indications (31)

- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000181

**Subject identifier**  
D002294
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000365

**Subject identifier**  
D015179
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000389

**Subject identifier**  
D008545
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Glioblastoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Lymphoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000681

**Subject identifier**  
D002292
- **Condition**  
Carcinoma, Squamous Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000707

**Subject identifier**  
D002294
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0002617

**Subject identifier**  
D008545
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004142

**Subject identifier**  
D015179
- **Condition**  
Carcinoma, Basal Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004193

**Subject identifier**  
D002280
- **Condition**  
Uveal Melanoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000616

**Subject identifier**  
D000098943
- **Condition**  
Gliosarcoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001465

**Subject identifier**  
D018316
- **Condition**  
Carcinoma, Merkel Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001471

**Subject identifier**  
D015266
- **Condition**  
Colonic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001950

**Subject identifier**  
D003110
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1001951

**Subject identifier**  
D015179
- **Condition**  
Sarcoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001968

**Subject identifier**  
D012509
- **Condition**  
Stomach Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001056

**Subject identifier**  
D013274
- **Condition**  
Liver Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002691

**Subject identifier**  
D008113

And 6 more, listed on the interactive page.

### Open Targets indications (59)

- **Condition identifier**  
EFO\_0000222

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000389
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000681

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000756
- **Condition identifier**  
EFO\_0001378

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0002617

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0004193

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000616

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001471

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001480

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001927

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0000544

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001325

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001402

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0001528

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002271

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002974

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003219

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004952

**Highest recorded phase**  
1

And 34 more, listed on the interactive page.

### Reported adverse events (4)

- **Event**  
adrenal insufficiency

**Reports**  
4

**Reporting signal score**

11.5086
- **Event**  
hepatitis

**Reports**  
5

**Reporting signal score**

10.822
- **Event**  
meningitis aseptic

**Reports**  
4

**Reporting signal score**

14.8673
- **Event**  
pericardial effusion

**Reports**  
5

**Reporting signal score**

12.3489

### Trial references (60)

- NCT01968109  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01968109)
- NCT03607890  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03607890)
- NCT05400265  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05400265)
- NCT05498480  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05498480)
- NCT02060188  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02060188)
- NCT02061761  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02061761)
- NCT02488759  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02488759)
- NCT02750514  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02750514)
- NCT02966548  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02966548)
- NCT02996110  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02996110)
- NCT03335540  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03335540)
- NCT03459222  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03459222)
- NCT03899155  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03899155)
- NCT04112498  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04112498)
- NCT02658981  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02658981)
- NCT02935634  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02935634)
- NCT03704077  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03704077)
- NCT03026140  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03026140)
- NCT03310619  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03310619)
- NCT03470922  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03470922)
- NCT03743766  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03743766)
- NCT03978611  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03978611)
- NCT05002569  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05002569)
- NCT05418972  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05418972)
- NCT05428007  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05428007)

And 35 more, listed on the interactive page.

## Dosing

**Dose**

160 mg relatlimab

**Route**

Intravenous

**How often**

Every 4 weeks

### Conditions of use

- Administer as an intravenous infusion over 30 minutes

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (3)

- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
Q1VQLQQWGAGLLKPSETLSLTCAVYGGSFSDYYWNWIRQPPGKGLEWIGEINHRGSTNSNPSLKSRVTLSLDTSKNQFSLKLRSVTAADTAVYYCAFGYSDYEYNWFDPWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG
- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
EIVLTQSPATLSLSPGERATLSCRASQSISSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPLTFGQGTNLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Disulfide bridges location

**Sequence**  
22-95$22''-95''$23'-88'$23'''-88'''$134'-194'$134'''-194'''$134-214'$134''-214'''$147-203$147''-203''$226-226''$229-229''$261-321$261''-321''$367-425$367''-425''

## National Drug Codes

- 0003-7125

## Related records

### Trials (88)

- A Phase 1, Bioavailability Study of Relatlimab in Combination With Nivolumab
- A Phase 2 Clinical Trial of Neoadjuvant Relatlimab and Nivolumab in High Risk, Clinical Stage II Cutaneous Melanoma
- A Randomized Phase 2 Trial of Nivolumab, Relatlimab Plus Ipilimumab vs. Nivolumab Plus Ipilimumab in First-line Advanced Renal Cell Carcinoma (RCC)
- A Safety and Efficacy Trial of JCAR017 Combinations in Subjects With Relapsed/Refractory B-cell Malignancies
- [A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-bms-986482-alone-or-as-combination-therapy-in-6d77cbe1-5589-468b-b0ee-4b57e5d96643.md)
- A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
- A Study of Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread
- A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer
- A Study of Relatlimab in Combination With Nivolumab in Participants With Advanced Liver Cancer Who Have Never Been Treated With Immuno-oncology Therapy After Prior Treatment With Tyrosine Kinase Inhibitors
- A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
- A Study of Relatlimab Plus Nivolumab Versus Nivolumab Alone in Participants With Advanced Melanoma
- A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma
- A Study to Assess Adjuvant Immunotherapy With Nivolumab Plus Relatlimab Versus Nivolumab Alone After Complete Resection of Stage III-IV Melanoma
- A Study to Assess Safety of Relatlimab With Ipilimumab in Participants With Advanced Melanoma Who Progressed on Anti-Programmed Cell Death Protein 1 (Anti-PD-1) Treatment
- A Study to Assess the Safety, and Tolerability of Nivolumab + Relatlimab Fixed-Dose Combination (FDC) In Unresectable or Metastatic Melanoma Participants In India
- [A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%](https://trialight.com/data/trial/a-study-to-compare-the-efficacy-of-nivolumab-and-relatlimab-71f07735-45a1-4bd2-9d98-f00e6c49ee26.md)
- A Study to Evaluate the Safety, Tolerability, and Efficacy of Relatlimab in Relapsed or Refractory B-Cell Malignancies
- A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of Relatlimab Plus Nivolumab in Pediatric and Young Adults With Hodgkin and Non-Hodgkin Lymphoma
- A Study to Evaluate Whether Participants With Melanoma Prefer Subcutaneous vs Intravenous Administration of Nivolumab and Nivolumab + Relatlimab Fixed-dose Combinations
- A Study to Test Combination Treatments in Participants With Advanced Gastric Cancer

### In development for (31)

- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 2
- [Basal cell carcinoma](https://trialight.com/data/condition/basal-cell-carcinoma-c09b4859-3642-5fab-89f0-8eede3ad7a6e.md) Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- Chordoma Phase 2
- Colon carcinoma Phase 2
- [Colorectal adenocarcinoma](https://trialight.com/data/condition/colorectal-adenocarcinoma-49107d5a-ece1-5f2b-8783-f2077e298ffa.md) Phase 3
- [Colorectal carcinoma](https://trialight.com/data/condition/colorectal-carcinoma-51401c02-7884-5c5c-bb91-90106e7d0d4a.md) Phase 3
- [Colorectal neoplasm](https://trialight.com/data/condition/colorectal-neoplasm-31f0a633-3abe-5df4-9d3a-9292c6541f1d.md) Phase 3
- [Cutaneous melanoma](https://trialight.com/data/condition/cutaneous-melanoma-c6e75b71-1c7c-59fe-a087-174eb0ec53df.md) Phase 3
- [Cutaneous neuroendocrine carcinoma](https://trialight.com/data/condition/cutaneous-neuroendocrine-carcinoma-ba38e774-613b-5117-ab12-d3c4e4cf6ad8.md) Phase 2
- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 1
- [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 1
- [Follicular lymphoma](https://trialight.com/data/condition/follicular-lymphoma-88de1ce9-ab0e-5d65-85c4-45a681fa2931.md) Phase 1
- [Gastric cancer](https://trialight.com/data/condition/gastric-cancer-3c1e2785-2672-5b3e-afce-9335f684c159.md) Phase 2
- Glioblastoma Phase 1
- Gliosarcoma Phase 1
- [Head and neck squamous cell carcinoma](https://trialight.com/data/condition/head-and-neck-squamous-cell-carcinoma-cbc3ae58-4a6c-52e4-a41b-274051db19fa.md) Phase 2
- [Hematopoietic and lymphoid cell neoplasm](https://trialight.com/data/condition/hematopoietic-and-lymphoid-cell-neoplasm-ed3616fa-22fe-5984-94b4-745416e01ef9.md) Phase 1
- [Hepatocellular carcinoma](https://trialight.com/data/condition/hepatocellular-carcinoma-fc1014ac-5a3c-551d-98ea-95306009e299.md) Phase 2
- Liver cancer Phase 2

### Targets (1)

- [LAG3](https://trialight.com/data/target/lag3-9427165f-23d0-56e2-8aec-0a1f9a15edc3.md) Lymphocyte activation gene 3 protein inhibitor

---

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