> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/relacorilant-3e88f9c3-9db2-466d-b646-da1d62538526
> Record changed: 2026-11-04

# Relacorilant

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

**Drug name**

Relacorilant

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

**Molecular weight**

586.57

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

**Structure (SMILES)**

Cn1cc(S(=O)(=O)N2CCC3=Cc4c(cnn4-c4ccc(F)cc4)C\[C@\]3(C(=O)c3cc(C(F)(F)F)ccn3)C2)cn1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

### Other names (34)

- (R)-(1-(4-FLUOROPHENYL)-6-((1-METHYL-1H-PYRAZOL-4-YL)SULFONYL)-1,4,5,6,7,8-HEXAHYDRO-4AH-PYRAZOLO(3,4-G)ISOQUINOLIN-4A-YL)(4-(TRIFLUOROMETHYL)PYRIDIN-2-YL)METHANONE
- cort 125134
- Cort 125134
- Cort-125134
- cort125134
- CORT125134
- cort125134 150 mg
- CORT125134 150 mg
- cort125134 250 mg
- CORT125134 250 mg
- lifyorli
- LIFYORLI
- r 1 4 fluorophenyl 6 1 methyl 1h pyrazol 4 yl sulfonyl 1 4 5 6 7 8 hexahydro 4ah pyrazolo 3 4 g isoquinolin 4a yl 4 trifluoromethyl pyridin 2 yl methanone
- relacorilant
- Relacorilant
- Relacorilant (3x100 mg hard-shell capsules)
- Relacorilant (3x100 mg softgel capsules)
- Relacorilant (6x50mg hard-shell capsules)
- relacorilant \[INN\]
- RELACORILANT \[USAN\]
- Relacorilant \[WHO-DD\]
- relacorilant 150 mg
- Relacorilant 150 mg
- relacorilant 300mg
- Relacorilant 300mg

And 9 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 1496510-51-0

**ChEMBL ID**

CHEMBL4068611

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

**InChIKey**

WANIDIGFXJFFEL-SANMLTNESA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4068611)

**PubChem compound IDs**

- 73051463

**RxNorm IDs (RxCUI)**

- 2739519

**FDA ingredient codes (UNII)**

- 2158753C7E

## Regulatory information

### European Union

**Status**

opinion

**Status date**

17 Sept 2026

**Approved indications**

Treatment of adult patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer

**Product number**

EMEA/H/C/006731

**Authorisation holder**

Corcept Therapeutics Netherlands B.V.

**Priority medicines scheme**

No

**Generic**

No

**Biosimilar**

No

**Generic medicines**

0

**Biosimilar medicines**

0

**Advanced therapy**

No

**Conditional approval**

No

**Additional monitoring**

No

**Accelerated assessment**

No

**Exceptional circumstances**

No

#### Therapeutic areas

- Carcinoma, Ovarian Epithelial
- Fallopian Tube Neoplasms
- Peritoneal Neoplasms

European medicines record

Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/lifyorli)

### Other regulatory facts

**Patents**

10

**Designations**

1

**Earliest recorded loss of exclusivity**

22 Dec 2041

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

Yes

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Approval status

**European Union (EMA)**

Opinion adopted, decision pending

## Pharmacology

### Drug classification

**Pharmacology name**

relacorilant

**Type**

Synthetic organic

**Drug name stem**

\-corilant

**Approval recorded by Guide to Pharmacology**

Yes

### Mechanisms of action (2)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
Glucocorticoid receptor

**Gene symbol**  
NR3C1

**Protein identifier**  
P04150

**Median affinity**

8.14

**Affinity units**  
pKi
- **Mechanism**  
Glucocorticoid receptor antagonist

**Action type**  
Antagonist

**Target**  
Glucocorticoid receptor

**Protein identifier**  
P04150

### Open Targets mechanisms

- **Mechanism**  
Glucocorticoid receptor antagonist

**Action type**  
Antagonist

**Target**  
Glucocorticoid receptor

### Investigated indications (10)

- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000673

**Subject identifier**  
D011471
- **Condition**  
Liver Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001421

**Subject identifier**  
D008107
- **Condition**  
Cushing Syndrome

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0003099

**Subject identifier**  
D003480
- **Condition**  
Fallopian Tube Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1000251

**Subject identifier**  
D005185
- **Condition**  
Adrenal Cortex Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1000796

**Subject identifier**  
D000306
- **Condition**  
Adrenocortical Hyperfunction

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1000797

**Subject identifier**  
D000308
- **Condition**  
Carcinoma, Pancreatic Ductal

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005184

**Subject identifier**  
D021441
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008170

**Subject identifier**  
D010051
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129

### Open Targets indications (25)

- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0001421

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003099

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1000797

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0000822

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0040270

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0001416

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002158

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005044

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005070

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005140

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005148

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006047

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0006639

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006640

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0007079
- **Condition identifier**  
MONDO\_0008170

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0015686

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018364

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018479

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0018912

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0957431

**Highest recorded phase**  
2

### Trial references (11)

- NCT02762981  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02762981)
- NCT02804750  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02804750)
- NCT03604198  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03604198)
- NCT03697109  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03697109)
- NCT03674814  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03674814)
- NCT05726292  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05726292)
- NCT03776812  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03776812)
- NCT04308590  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04308590)
- NCT04329949  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04329949)
- NCT04373265  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04373265)
- NCT06094725  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06094725)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

0

**Polar surface area**

102.98

**Calculated partition coefficient (ALogP)**

4.06

**Calculated partition coefficient (XLogP)**

2.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

1

**Rotatable bonds**

5

**Heavy atoms**

41

**Molecular formula**

C27H22F4N6O3S

**Monoisotopic mass**

586.14102241

**Natural product**

No

## Evidence counts

**Recorded assays**

170

**Active assays**

13

### Active assay types

- Confirmatory

## Pharmacologic actions

- Antineoplastic Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000970.html)

## Biological measurements

These details could not be displayed.

## Related records

### Trials (25)

- A Study Designed to See How \[14C\]-CORT125134 is Taken up, Broken Down and Removed From the Body
- A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer
- A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas
- A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome
- A Study to Determine the Relative Bioavailability of Two New Relacorilant Capsule Variants
- A Study to Evaluate the Effect of Food on the Oral Bioavailability of Relacorilant in Healthy Subjects
- A Study to Evaluate the Effects of Hepatic Impairment on the Pharmacokinetics of Relacorilant
- A Study to Evaluate the Pharmacokinetics of the CORT125134 Phase 2 Formulation in Healthy Male Subjects
- A Study to Evaluate the Pharmacokinetics of the Current Capsule Formulation of CORT125134 in Healthy Subjects
- CORT125134 Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD)
- Effect of Relacorilant on the Pharmacokinetics of the Sensitive P-glycoprotein Substrate Dabigatran Etexilate in Healthy Participants
- Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome
- Relacorilant and Nab-Paclitaxel in Recurrent or Metastatic Cervical Cancer
- Relacorilant Food Effect Study in Healthy Subjects
- [Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers](https://trialight.com/data/trial/relacorilant-in-combination-with-different-treatment-65ed442e-00f9-486e-9266-a310b02d8ddb.md)
- Relacorilant in Combination With Nab-Paclitaxel in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube Cancer
- Relacorilant With Nab-Paclitaxel and Gemcitabine in Patients With Metastatic Pancreatic Adenocarcinoma
- Study in Healthy Subjects to Determine the Effect of an Inhibitor on Exposure to Relacorilant and Its Metabolites
- Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s
- Study of Drug 1 (Enzalutamide) Plus Drug 2 (Relacorilant) for Patients With Prostate Cancer

### In development for (20)

- Adrenal cortex carcinoma Phase 1
- Adrenal gland hyperfunction Phase 3
- Congenital adrenal hyperplasia Phase 3
- [Cushing syndrome](https://trialight.com/data/condition/cushing-syndrome-bf694ab1-28dd-5b0a-bb0e-fbe035b96fed.md) Phase 3
- Endogenous Cushing syndrome Phase 2
- [Fallopian tube cancer](https://trialight.com/data/condition/fallopian-tube-cancer-b95d05ee-41d5-565a-87e1-041170b88760.md) Phase 3
- Fallopian tube carcinoma Phase 2
- [Female reproductive organ cancer](https://trialight.com/data/condition/female-reproductive-organ-cancer-1207d84e-931f-51b6-90d9-6b2135cdebbb.md) Phase 2
- [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) Phase 3
- [Liver disorder](https://trialight.com/data/condition/liver-disorder-8388d30a-2581-5015-9ddf-adc5f6a331d7.md) Phase 1
- Malignant epithelial tumor of ovary Phase 3
- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 1
- [Ovarian cancer](https://trialight.com/data/condition/ovarian-cancer-f64f2018-55a5-553a-8960-76cb4906aa17.md) Phase 2
- [Ovarian carcinoma](https://trialight.com/data/condition/ovarian-carcinoma-e5ec8fdc-01ec-5cd9-9507-107d23d3a30b.md) Phase 3
- [Pancreatic adenocarcinoma](https://trialight.com/data/condition/pancreatic-adenocarcinoma-fd65444c-0bc5-53ed-8c6a-62d9809145d0.md) Phase 2
- [Pancreatic ductal adenocarcinoma](https://trialight.com/data/condition/pancreatic-ductal-adenocarcinoma-77c1c5a8-638b-51d0-b18e-2c881b8902e5.md) Phase 3
- Primary peritoneal carcinoma Phase 3
- Prostate adenocarcinoma Phase 2
- [Prostate cancer](https://trialight.com/data/condition/prostate-cancer-3659fc70-617b-5868-a093-ae819ffc6755.md) Phase 2
- [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 3

### Other linked conditions (1)

- Alcohol dependence

### Targets (1)

- [NR3C1](https://trialight.com/data/target/nr3c1-98974b8d-fb89-5483-955e-d4a994c71532.md) Glucocorticoid receptor antagonist

---

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