> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/regramostim-71097184-8048-4d6e-a5cc-194c86388a4e
> Record changed: 2026-10-13

# Regramostim

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107881)

Drug type

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107881)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107881)

## Names and chemistry

**Drug type**

Protein

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107881)

**Drug name**

Regramostim

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107881)

### Other names (57)

- colony stimulating factor 2 human clone pcsf 1 protein moiety reduced glycoform gmc 89 107
- COLONY-STIMULATING FACTOR 2 (HUMAN CLONE PCSF-1 PROTEIN MOIETY REDUCED), GLYCOFORM GMC 89-107
- gm csf
- gm csf cho cell
- GM-CSF
- GM-CSF (CHO CELL)
- gmc 89 107
- GMC 89-107
- GMC-89-107
- high dose recombinant sars cov 2 vaccine cho cell
- high-dose Recombinant SARS-CoV-2 Vaccine (CHO cell)
- Human Erythropoiesis Injection (CHO cell)
- inhaled molgramostim (rhGM-CSF)
- leucotropin glycoform gmc 89 107
- Leucotropin glycoform gmc 89-107
- low-dose Recombinant SARS-CoV-2 Vaccine (CHO cell)
- Part1:Recombinant two-component COVID-19 vaccine (CHO cell)
- Part2: Recombinant two-component COVID-19 vaccine (CHO cell)
- Recombinant COVID-19 vaccine (CHO cell)
- Recombinant COVID-19 Vaccine (CHO cell)
- Recombinant COVID-19 Vaccine (CHO Cell)
- Recombinant COVID-19 vaccine(CHO cell)
- Recombinant Erythropoiesis Stimulating Protein Injection(CHO cell)
- Recombinant Human Erythropoiesis Injection (CHO cell)
- recombinant human Thrombin(CHO cell)

And 32 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 127757-91-9

**ChEMBL ID**

CHEMBL2107881

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2107881)

**FDA ingredient codes (UNII)**

- KR89Q40F01

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Drug name stem**

\-stim; -stim

### Mechanisms of action

- **Mechanism**  
Granulocyte colony stimulating factor receptor agonist

**Action type**  
Agonist

**Target**  
Granulocyte colony-stimulating factor receptor

**Protein identifier**  
Q99062

### Open Targets mechanisms

- **Mechanism**  
Granulocyte colony stimulating factor receptor agonist

**Action type**  
Agonist

**Target**  
Granulocyte colony-stimulating factor receptor

### Investigated indications (28)

- **Condition**  
HIV Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000180

**Subject identifier**  
D015658
- **Condition**  
Burkitt Lymphoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000309

**Subject identifier**  
D002051
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000365

**Subject identifier**  
D015179
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000389

**Subject identifier**  
D008545
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Glioblastoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000519

**Subject identifier**  
D005909
- **Condition**  
Lymphoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Neuroblastoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000621

**Subject identifier**  
D009447
- **Condition**  
Carcinoma, Renal Cell

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000681

**Subject identifier**  
D002292
- **Condition**  
Melanoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000756

**Subject identifier**  
D008545
- **Condition**  
HIV Infections

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000764

**Subject identifier**  
D015658
- **Condition**  
Mesothelioma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000770

**Subject identifier**  
D008654
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0003060

**Subject identifier**  
D002289
- **Condition**  
Nasopharyngeal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004252

**Subject identifier**  
D009303
- **Condition**  
Peripheral Arterial Disease

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0004265

**Subject identifier**  
D058729
- **Condition**  
Appendicitis

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0007149

**Subject identifier**  
D001064
- **Condition**  
Varicose Ulcer

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001923

**Subject identifier**  
D014647
- **Condition**  
Colorectal Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:1001951

**Subject identifier**  
D015179
- **Condition**  
Pulmonary Alveolar Proteinosis

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0001437

**Subject identifier**  
D011649
- **Condition**  
Kidney Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0002367

**Subject identifier**  
D007680
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Breast Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0007254

**Subject identifier**  
D001943
- **Condition**  
Ovarian Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008170

**Subject identifier**  
D010051
- **Condition**  
Prostatic Neoplasms, Castration-Resistant

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0008315

**Subject identifier**  
D064129

And 3 more, listed on the interactive page.

### Open Targets indications (105)

- **Condition identifier**  
EFO\_0000180
- **Condition identifier**  
EFO\_0000365

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0000389
- **Condition identifier**  
EFO\_0000519

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000574

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000618
- **Condition identifier**  
EFO\_0000621

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000681

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000756

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0001378

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004252

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0004265

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0007149

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000211

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001829

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001904

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001923

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001927

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0000789
- **Condition identifier**  
HP\_0001394
- **Condition identifier**  
HP\_0100806

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001056

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0001437

**Highest recorded phase**  
2

And 80 more, listed on the interactive page.

### Reported adverse events (26)

- **Event**  
alanine aminotransferase abnormal

**Reports**  
6

**Reporting signal score**

18.093
- **Event**  
aspartate aminotransferase abnormal

**Reports**  
7

**Reporting signal score**

25.0595
- **Event**  
bone marrow failure

**Reports**  
12

**Reporting signal score**

14.382
- **Event**  
bone pain

**Reports**  
21

**Reporting signal score**

26.8779
- **Event**  
capillary leak syndrome

**Reports**  
6

**Reporting signal score**

17.466
- **Event**  
chest pain

**Reports**  
26

**Reporting signal score**

12.8805
- **Event**  
chills

**Reports**  
32

**Reporting signal score**

32.9116
- **Event**  
device related bacteraemia

**Reports**  
17

**Reporting signal score**

113.139
- **Event**  
dyspnoea

**Reports**  
60

**Reporting signal score**

21.5738
- **Event**  
febrile neutropenia

**Reports**  
4

**Reporting signal score**

6.21572
- **Event**  
frostbite

**Reports**  
1

**Reporting signal score**

5.90286
- **Event**  
hyperhidrosis

**Reports**  
34

**Reporting signal score**

36.1004
- **Event**  
hypotension

**Reports**  
52

**Reporting signal score**

40.881
- **Event**  
hypoxia

**Reports**  
14

**Reporting signal score**

16.3108
- **Event**  
karyotype analysis abnormal

**Reports**  
1

**Reporting signal score**

6.41328
- **Event**  
low birth weight baby

**Reports**  
3

**Reporting signal score**

9.56339
- **Event**  
mutagenic effect

**Reports**  
1

**Reporting signal score**

7.91689
- **Event**  
obstruction gastric

**Reports**  
5

**Reporting signal score**

17.216
- **Event**  
premature baby

**Reports**  
3

**Reporting signal score**

5.75674
- **Event**  
pupillary reflex impaired

**Reports**  
2

**Reporting signal score**

8.52392
- **Event**  
pyrexia

**Reports**  
66

**Reporting signal score**

42.5867
- **Event**  
refractory cancer

**Reports**  
1

**Reporting signal score**

5.7319
- **Event**  
small intestinal obstruction

**Reports**  
9

**Reporting signal score**

14.8089
- **Event**  
syncope

**Reports**  
32

**Reporting signal score**

30.7008
- **Event**  
transfusion reaction

**Reports**  
4

**Reporting signal score**

13.9125

And 1 more, listed on the interactive page.

### Trial references (41)

- NCT00001237  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001237)
- NCT00208975  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00208975)
- NCT00272493  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00272493)
- NCT00429416  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00429416)
- NCT00458536  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00458536)
- NCT00458601  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00458601)
- NCT00524277  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00524277)
- NCT00841399  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00841399)
- NCT00854789  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00854789)
- NCT00582140  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00582140)
- NCT00849121  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00849121)
- NCT01341652  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01341652)
- NCT01784913  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01784913)
- NCT02452307  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02452307)
- NCT00969722  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00969722)
- NCT01757626  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01757626)
- NCT06013618  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06013618)
- NCT01041417  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01041417)
- NCT01176552  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01176552)
- NCT01232712  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01232712)
- NCT01265433  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01265433)
- NCT01890980  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01890980)
- NCT01329809  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01329809)
- NCT01363206  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01363206)
- NCT01368276  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01368276)

And 16 more, listed on the interactive page.

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

## Related records

### Trials (291)

- 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of Second or Greater Remission of High-Risk Neuroblastoma
- 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Primary Refractory Neuroblastoma in Bone Marrow
- A Clinical Study to Evaluate the Safety and Immunogenicity of the Recombinant COVID-19 Vaccine (Sf9 Cell) as a Booster
- A Clinical Trial of A COVID-19 Vaccine Named Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
- A Clinical Trial of Immuno-bridging Between Different Manufacture Scales of Recombinant COVID-19 Vaccine (Sf9 Cell)
- A Clinical Trial of Immunobridging and Lot-to-lot Consistency of COVID-19 Vaccine (Ad5-nCoV) in Different Age Groups.
- [A Clinical Trial of Recombinant COVID-19 Bivalent (XBB+Prototype) Protein Vaccine (Sf9 Cell) in Booster Vaccination](https://trialight.com/data/trial/a-clinical-trial-of-recombinant-covid-19-bivalent-xbb-6b1f79b9-6e5c-4ed8-adf2-3b5535c20652.md)
- A Clinical Trial on Booster Immunization of Two COVID-19 Vaccines Constructed From Different Technical Routes
- [A Clinical Trial on Sequential Immunization of Recombinant COVID-19 Vaccine (CHO Cell, NVSI-06-09) and Inactivated COVID-19 Vaccine (Vero Cell)](https://trialight.com/data/trial/a-clinical-trial-on-sequential-immunization-of-recombinant-11cc012a-c2b3-4edc-a480-42a18a3b47e0.md)
- A Clinical Trial to Evaluate the Recombinant SARS-CoV-2 Vaccine (CHO Cell) for COVID-19
- A Comparison of Dendritic Cell Content and T-Cell Phenotype Between Granulocyte Colony-Stimulating Factor (G-CSF) or G-CSF + Granulocyte Macrophage (GM)-CSF
- A Global Phase III Clinical Trial of Recombinant COVID- 19 Vaccine (Sf9 Cells)
- A Personalized NeoAntigen Cancer Vaccine Combined With Anti-PD-1 in Melanoma
- A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma
- A Phase 2 Clinical Study of Pegerythropoietin Injection (RD01) for the Treatment of Anemia in Chronic Renal Failure Patients With Hemodialysis
- A Phase 2 Trial for Patients With Metastatic Solid Cancer
- A Phase I Study of a DNA Vaccine Encoding Androgen Receptor Ligand-Binding Domain (AR LBD) +/-GMCSF
- A Phase I Study to Evaluate Safety, Tolerability, and Immunogenicity of a PIKA COVID-19 Vaccine in Healthy Individuals
- A Phase I/II Open-Label Study of Ipilimumab and GM-CSF Administered to Unresectable Stage IIIC and Stage IV Melanoma Patients
- A Phase I/IIa Study of UV1 Vaccination in Patients With Non Small Cell Lung Cancer.

### In development for (28)

- [Adult acute respiratory distress syndrome](https://trialight.com/data/condition/adult-acute-respiratory-distress-syndrome-52101d99-65d3-54cf-b5da-f664febc6a7e.md) Phase 2
- Appendicitis Phase 2
- Autoimmune pulmonary alveolar proteinosis Phase 2
- [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) Phase 2
- Burkitt lymphoma Phase 2
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- [Colorectal adenocarcinoma](https://trialight.com/data/condition/colorectal-adenocarcinoma-49107d5a-ece1-5f2b-8783-f2077e298ffa.md) Phase 2
- [Colorectal carcinoma](https://trialight.com/data/condition/colorectal-carcinoma-51401c02-7884-5c5c-bb91-90106e7d0d4a.md) Phase 2
- [Cutaneous melanoma](https://trialight.com/data/condition/cutaneous-melanoma-c6e75b71-1c7c-59fe-a087-174eb0ec53df.md) Phase 3
- [Diffuse large B-cell lymphoma](https://trialight.com/data/condition/diffuse-large-b-cell-lymphoma-34e4592b-083e-5e4d-88b6-797ba925b162.md) Phase 2
- Glioblastoma Phase 2
- [HIV infectious disease](https://trialight.com/data/condition/hiv-infectious-disease-1260f28c-d667-55f9-b221-15d5017fde05.md) Phase 2
- Kidney cancer Phase 1
- [Lung cancer](https://trialight.com/data/condition/lung-cancer-c4ca1fe0-9b3d-5957-a668-2d6cf26bd16a.md) Phase 2
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 2
- Malignant colon neoplasm Phase 2
- Malignant glioma Phase 2
- Malignant pleural mesothelioma Phase 2
- [Melanoma](https://trialight.com/data/condition/melanoma-457e9de6-dcd9-56fb-be48-0290fb4386ef.md) Phase 3
- [Nasopharyngeal neoplasm](https://trialight.com/data/condition/nasopharyngeal-neoplasm-48691b20-fad8-5218-b6aa-4dd6c49469e4.md) Phase 2

### Other linked conditions (1)

- Nervous system disorder

### Targets (1)

- [CSF3R](https://trialight.com/data/target/csf3r-7b84eab7-d92f-5a62-9246-8b76c06b0b44.md) Granulocyte colony stimulating factor receptor agonist

---

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