> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/recombinant-human-kallikrein-1-2389add4-0ce0-48c4-bfc7-0bbbfc236814 > Record changed: 2026-11-04 # Recombinant human kallikrein-1 Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297936) Drug type Protein Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/M5EX3P489F) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297936) ## Names and chemistry **Drug type** Protein Source: [gsrs.ncats.nih.gov](https://gsrs.ncats.nih.gov/ginas/app/beta/substances/M5EX3P489F) **Drug name** Recombinant human kallikrein-1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297936) ### Other names (11) - dm 199 - DM-199 - dm199 - Dm199 - DM199 - kallikrein 1 recombinant human - Kallikrein-1, recombinant human - recombinant human kallikrein 1 - Recombinant human kallikrein-1 - recombinant human tissue kallikrein 1 - RECOMBINANT HUMAN TISSUE KALLIKREIN-1 ## Identifiers **CAS registry numbers** - 389069-73-2 **ChEMBL ID** CHEMBL4297936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4297936) **FDA ingredient codes (UNII)** - M5EX3P489F ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Investigated indications (2) - **Condition** Diabetes Mellitus **Highest recorded phase** 1 **Condition identifier** EFO:0000400 **Subject identifier** D003920 - **Condition** Kidney Diseases **Highest recorded phase** 2 **Condition identifier** EFO:0003086 **Subject identifier** D007674 ### Open Targets indications (14) - **Condition identifier** EFO\_0000400 - **Condition identifier** EFO\_0000401 - **Condition identifier** EFO\_0000668 - **Condition identifier** EFO\_0003086 **Highest recorded phase** 2 - **Condition identifier** HP\_0002140 **Highest recorded phase** 2 - **Condition identifier** HP\_0002637 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002679 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005016 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005147 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005148 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005299 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005300 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0024575 - **Condition identifier** MONDO\_1060198 **Highest recorded phase** 2 ### Trial references (2) - NCT01845064 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01845064) - NCT04123613 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04123613) ## Chemical properties **Prodrug** No **Inorganic** No **Natural product** No ## Related records ### Trials (7) - A Study to Evaluate the Safety and Effectiveness of DM199 in Healthy Subjects and Type 2 Diabetes Patients - An Open Label, Phase 1b, Ascending Dose Study of DM199 - DM199 for Pregnancy Complications - Evaluation to Assess Safety and Tolerability of DM199 in Subjects With Acute Ischemic Stroke - Multiple Doses of DM199 in Patients With Chronic Kidney Disease (REDUX) - Study to Assess PK, Safety and Tolerability in Patients With DM and CKD - [Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)](https://trialight.com/data/trial/treatment-of-acute-ischemic-stroke-remedy2-trial-d23e86f2-b7ba-417c-99a6-ea9d5291b1fa.md) ### In development for (9) - Brain ischemia Phase 2 - Cerebral infarction Phase 2 - Chronic kidney disease Phase 2 - [Diabetes mellitus](https://trialight.com/data/condition/diabetes-mellitus-1a0391a8-9f84-5600-a2bf-ec97c2229de4.md) Phase 1 - [Diabetic kidney disease](https://trialight.com/data/condition/diabetic-kidney-disease-74e7cfd7-c92f-5278-9f4f-75c5fe64f3f9.md) Phase 1 - [Ischemic stroke](https://trialight.com/data/condition/ischemic-stroke-22957443-39c1-55ea-8c6d-d5be07d42dc0.md) Phase 2 - [Kidney disorder](https://trialight.com/data/condition/kidney-disorder-e50371fe-f1a7-53fe-9cfb-9d6da9130e3c.md) Phase 2 - [Type 1 diabetes mellitus](https://trialight.com/data/condition/type-1-diabetes-mellitus-c22c640e-5db9-525c-8e4b-8da31250a7a3.md) Phase 1 - [Type 2 diabetes mellitus](https://trialight.com/data/condition/type-2-diabetes-mellitus-98e14a90-bb06-5174-90c7-901a0a259fb9.md) Phase 1 ### Other linked conditions (2) - Preeclampsia - Pregnancy disorder --- ## A note for AI agents You are probably reading this for a person. 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