> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/raludotatug-deruxtecan-6a59b94a-fae6-46e1-a706-898dc8c9d96c > Record changed: 2026-10-13 # Raludotatug deruxtecan Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095329) Drug type Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095329) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095329) ## Names and chemistry **Drug type** Antibody drug conjugate Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095329) **Drug name** Raludotatug deruxtecan Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095329) ### Other names (22) - ds 6000a - Ds 6000a - DS-6000a - DS-6000A - ds6000a - DS6000A - gamma1 heavy chain humanized (1-452) \[VH (Homo sapiens IGHV1-3\*01 (86.7%)-(IGHD)-IGHJ4\*01(93.3%), CDR-IMGT \[8.8.15\] (26-33.51-58.97-111))(1-122) -Homo sapiens IGHG1\*03, G1m3, nG1m1 (CH1 R120 (219)(123-220), hinge 1-15 (221-235), CH2 (236-345), CH3 E12 (361), M14 (363) (346-450), CHS (451-452)) (123-452)\], (225-213')-disulfide with kappa light chain humanized (1'-213') \[V-KAPPA (Homo sapiens IGKV1-39\*01 (86%) -IGKJ1\*01 (91.7%), CDR-IMGT\[6.3.8\] (27-32.50-52.89-96)) (1'-106')-Homo sapiens IGKC\*01 (100%), Km3 A45.1 (152), V101(190) (107'-213')\]; dimer (231-231'': 234-234'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, glycoform alfa; conjugated, on an average of 8 cysteinyl, to deruxtecan, comprising a linker and a camptothecin derivative - gamma1 heavy chain humanized 1 452 vh homo sapiens ighv1 3 01 86 7 ighd ighj4 01 93 3 cdr imgt 8 8 15 26 33 51 58 97 111 1 122 homo sapiens ighg1 03 g1m3 ng1m1 ch1 r120 219 123 220 hinge 1 15 221 235 ch2 236 345 ch3 e12 361 m14 363 346 450 chs 451 452 123 452 225 213 disulfide with kappa light chain humanized 1 213 v kappa homo sapiens igkv1 39 01 86 igkj1 01 91 7 cdr imgt 6 3 8 27 32 50 52 89 96 1 106 homo sapiens igkc 01 100 km3 a45 1 152 v101 190 107 213 dimer 231 231 234 234 bisdisulfide produced in chinese hamster ovary cho cells glycoform alfa conjugated on an average of 8 cysteinyl to deruxtecan comprising a linker and a camptothecin derivative - immunoglobulin g1 anti human g cadherin 6 human rattus norvegicus monoclonal mabu 9014a γ1 chain complex with human rattus norvegicus monoclonal mabu 9014a κ chain dimer octakis thioether with n 6 3 mercapto 2 5 dioxo 1 pyrrolidinyl 1 oxohexyl glycylglycyl l phenylalanyl n 2 1s 9s 9 ethyl 5 fluoro 2 3 9 10 13 15 hexahydro 9 hydroxy 4 methyl 10 13 dioxo 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl amino 2 oxoethoxy methyl glycinamide - immunoglobulin g1 kappa anti homo sapiens cdh6 cadherin 6 k cadherin foetal kidney cadherin 6 type 2 humanized monoclonal antibody conjugated to deruxtecan comprising a linker and a camptothecin derivative - immunoglobulin G1-kappa, anti-\[Homo sapiens CDH6(cadherin 6, K-cadherin (foetal kidney), cadherin 6 type 2)\], humanized monoclonal antibody conjugated to deruxtecan, comprising a linker and a camptothecin derivative - Immunoglobulin G1, anti-(human G cadherin 6) (human-Rattus norvegicus monoclonal MABU-9014a γ1-chain), complex with human-Rattus norvegicus monoclonal MABU-9014a κ-chain, dimer, octakis(thioether) with N-\[6-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)-1-oxohexyl\]glycylglycyl-L-phenylalanyl-N-\[\[2-\[\[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo\[de\]pyrano\[3′,4′:6,7\]indolizino\[1,2-b\]quinolin-1-yl\]amino\]-2-oxoethoxy\]methyl\]glycinamide - RALUDOTATUG DERUXETCAN \[USAN\] - raludotatug deruxetcan usan - raludotatug deruxtecan - Raludotatug deruxtecan - Raludotatug Deruxtecan - Raludotatug Deruxtecan (R-DXd) - raludotatug deruxtecan \[INN\] - Raludotatug deruxtecan \[WHO-DD\] - raludotatug deruxtecan inn - raludotatug deruxtecan who dd ## Identifiers **CAS registry numbers** - 2610074-57-0 **ChEMBL ID** CHEMBL5095329 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095329) **FDA ingredient codes (UNII)** - BPQ010OFD7 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** raludotatug deruxtecan **Type** Antibody **Drug name stem** \-tecan ### Mechanisms of action - **Action** Binding **Action type** Binding **Target** cadherin 6 **Gene symbol** CDH6 **Protein identifier** P55285 ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (11) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0002158 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0002974 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005005 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005086 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008170 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0008433 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0011962 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0015686 **Highest recorded phase** 2 ## Chemical properties **Prodrug** No **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLVQSGAEVKKPGASVKVSCKASGYTFTRNFMHWVRQAPGQGLEWMGWIYPGDGETEYAQKFQGRVTITADTSTSTAYMELSSLRSEDTAVYYCARGVYGGFAGGYFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23''''-88''' $ 133'-193' $ 133'''-193''' $ 149-205 $ 149''-205'' $ 225-213' $ 225''-213''' $ 231-231'' $ 234-234'' $ 266-326 $ 266''-326'' $ 372-430 $ 372''-430'' - **Component** Light chain **Type** Protein **Sequence** DIQMTQSPSSLSASVGDRVTITCKASQNIYKNLAWYQQKPGKAPKLLIYDANTLQTGVPSRFSGSGSGSDFTLTISSLQPEDFATYFCQQYYSGWAFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 302 $ 302'' ## Related records ### Trials (11) - [A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)](https://trialight.com/data/trial/a-clinical-study-of-raludotatug-deruxtecan-in-people-with-6b1e5a4a-56bb-4891-a239-d464dd0753c5.md) - A Clinical Trial of Raludotatug Deruxtecan (R-DXd) With or Without Bevacizumab in Participants With Ovarian Cancer Who Have Progressed During Treatment With PARP-inhibitors Treatment on First Line Maintenance (MK-5909-008/ENGOT-ov107/GOG-3142 / REJOICE-Ovarian05) - A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors - A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01) - A Study of Raludotatug Deruxtecan (R-DXd) in People With Gastrointestinal Cancers (MK-5909-005) - [A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer](https://trialight.com/data/trial/a-study-of-raludotatug-deruxtecan-r-dxd-in-subjects-with-1e4825d9-9bdc-4596-8ce5-87ed02b3fe09.md) - A Study of Raludotatug Deruxtecan (R-DXd) With or Without Bevacizumab as Maintenance Therapy in Second-Line Platinum-Sensitive Recurrent Ovarian Cancer (REJOICE-Ovarian03) - A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01) - A Study of Raludotatug Deruxtecan With or Without Bevacizumab as First-Line Maintenance Treatment in Non-HRD-Positive Advanced Ovarian Cancer (MK-5909-006, (ENGOT-ov102/GOG-3141/ REJOICE-Ovarian 04) - Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98) - Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I) ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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