> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/rabeprazole-c1f8c7ed-cc36-469a-a527-ead5eea1412a
> Record changed: 2026-11-04

# Rabeprazole

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

First approval year

1999

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

## Development status

**First approval year**

1999

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

**Drug name**

Rabeprazole

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

**Molecular weight**

359.45

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

**Structure (SMILES)**

COCCCOc1ccnc(C\[S+\](\[O-\])c2nc3ccccc3\[nH\]2)c1C

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

### Other names (44)

- Current proton pump inhibitor (PPI)
- current proton pump inhibitor ppi
- e 3810 ppi
- E-3810 (PPI)
- e3810
- E3810
- eraloc
- Eraloc
- ly 307640
- Ly-307640
- ly307640
- LY307640
- one proton pump inhibitor ppi
- one proton pump inhibitor(PPI)
- pariprazole
- Pariprazole
- ppi
- PPI (proton pump inhibitor)
- ppi 20 mg domperidone 10 mg
- ppi proton pump inhibitor
- Proton Pump Inhibitor (PPI) Therapy
- proton pump inhibitor ppi
- proton pump inhibitor ppi therapy
- proton pump inhibitors ppi
- rabeprazol

And 19 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 117976-89-3

**ChEMBL ID**

CHEMBL1219

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

**InChIKey**

YREYEVIYCVEVJK-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

**PubChem compound IDs**

- 5029

**RxNorm IDs (RxCUI)**

- 114979

**FDA ingredient codes (UNII)**

- 32828355LL

### ATC classification codes (2)

- A02BC04
- A02BC54

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1219)

## Regulatory information

### United States

**Applicant**

WAYLIS THERAP

**Approval date**

19 Aug 1999

**Application number**

NDA020973

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

## Approval status

**United States (FDA)**

Approved

## Pharmacology

### Drug classification

**Pharmacology name**

rabeprazole

**Type**

Synthetic organic

**Drug name stem**

\-prazole

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral

### Open Targets mechanisms

- **Mechanism**  
Potassium-transporting ATPase inhibitor

**Action type**  
Inhibitor

**Target**  
Potassium-transporting ATPase

### DrugCentral mechanisms

- **Action type**  
Inhibitor

**Gene symbol**  
ATP4A|ATP4B

**Protein identifier**  
P20648|P51164

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (13)

- **Condition**  
Lymphoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000574

**Subject identifier**  
D008223
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Hematologic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0001642

**Subject identifier**  
D019337
- **Condition**  
Gastroesophageal Reflux

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0003948

**Subject identifier**  
D005764
- **Condition**  
Duodenal Ulcer

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004607

**Subject identifier**  
D004381
- **Condition**  
Communicable Diseases

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0005741

**Subject identifier**  
D003141
- **Condition**  
Dyspepsia

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0008533

**Subject identifier**  
D004415
- **Condition**  
Helicobacter Infections

**Highest recorded phase**  
3

**Condition identifier**  
EFO:1000961

**Subject identifier**  
D016481
- **Condition**  
Cholangiocarcinoma

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001961

**Subject identifier**  
D018281
- **Condition**  
Gastrointestinal Hemorrhage

**Highest recorded phase**  
3

**Condition identifier**  
HP:0002239

**Subject identifier**  
D006471
- **Condition**  
Peptic Ulcer

**Highest recorded phase**  
4

**Condition identifier**  
HP:0004398

**Subject identifier**  
D010437
- **Condition**  
Amyotrophic Lateral Sclerosis

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004976

**Subject identifier**  
D000690
- **Condition**  
Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369

### Open Targets indications (26)

- **Condition identifier**  
EFO\_0000771
- **Condition identifier**  
EFO\_0001642

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0003948
- **Condition identifier**  
EFO\_0004607
- **Condition identifier**  
EFO\_0005741

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0005769
- **Condition identifier**  
EFO\_0008533

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0009454
- **Condition identifier**  
EFO\_1000961

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_1001355

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0002239

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0004398
- **Condition identifier**  
HP\_0004398

**Highest recorded phase**  
4
- **Condition identifier**  
HP\_0100749
- **Condition identifier**  
MONDO\_0001126
- **Condition identifier**  
MONDO\_0002268

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004247
- **Condition identifier**  
MONDO\_0004247

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0004976

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0004979

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005068

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0005113

**Highest recorded phase**  
4
- **Condition identifier**  
MONDO\_0005412

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006781

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006896

**Highest recorded phase**  
3

And 1 more, listed on the interactive page.

### Reported adverse events (51)

- **Event**  
abdominal discomfort

**Reports**  
43

**Reporting signal score**

26.9726
- **Event**  
anorectal discomfort

**Reports**  
10

**Reporting signal score**

25.5295
- **Event**  
asthma

**Reports**  
66

**Reporting signal score**

84.1835
- **Event**  
autoimmune haemolytic anaemia

**Reports**  
11

**Reporting signal score**

24.2048
- **Event**  
bacterial infection

**Reports**  
32

**Reporting signal score**

67.6241
- **Event**  
bronchial secretion retention

**Reports**  
10

**Reporting signal score**

37.2526
- **Event**  
clumsiness

**Reports**  
17

**Reporting signal score**

57.6161
- **Event**  
colitis microscopic

**Reports**  
26

**Reporting signal score**

74.5808
- **Event**  
drug withdrawal syndrome neonatal

**Reports**  
18

**Reporting signal score**

34.7633
- **Event**  
enterocolitis haemorrhagic

**Reports**  
16

**Reporting signal score**

50.2326
- **Event**  
eosinophil count increased

**Reports**  
44

**Reporting signal score**

122.756
- **Event**  
eosinophilic bronchitis

**Reports**  
32

**Reporting signal score**

203.456
- **Event**  
fall

**Reports**  
83

**Reporting signal score**

29.9938
- **Event**  
flatulence

**Reports**  
22

**Reporting signal score**

24.3218
- **Event**  
full blood count abnormal

**Reports**  
13

**Reporting signal score**

33.5646
- **Event**  
gait spastic

**Reports**  
13

**Reporting signal score**

61.8915
- **Event**  
gastric polyps

**Reports**  
26

**Reporting signal score**

93.8721
- **Event**  
gastrooesophageal reflux disease

**Reports**  
87

**Reporting signal score**

153.266
- **Event**  
hepatic function abnormal

**Reports**  
27

**Reporting signal score**

24.5821
- **Event**  
hypertonic bladder

**Reports**  
16

**Reporting signal score**

51.9531
- **Event**  
hypocalcaemia

**Reports**  
59

**Reporting signal score**

122.357
- **Event**  
hypokalaemia

**Reports**  
50

**Reporting signal score**

60.253
- **Event**  
hypomagnesaemia

**Reports**  
78

**Reporting signal score**

210.061
- **Event**  
hyponatraemia

**Reports**  
43

**Reporting signal score**

33.9345
- **Event**  
hypoparathyroidism secondary

**Reports**  
10

**Reporting signal score**

50.6858

And 26 more, listed on the interactive page.

### Trial references (33)

- NCT00165841  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00165841)
- NCT00222170  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00222170)
- NCT00237367  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00237367)
- NCT00251732  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00251732)
- NCT00304421  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00304421)
- NCT00464308  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00464308)
- NCT00539240  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00539240)
- NCT00787891  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00787891)
- NCT00838526  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00838526)
- NCT00839306  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00839306)
- NCT00857597  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00857597)
- NCT01136317  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01136317)
- NCT01391715  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01391715)
- NCT02135107  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02135107)
- NCT04494243  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04494243)
- NCT04622358  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04622358)
- NCT01089543  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01089543)
- NCT01513785  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01513785)
- NCT01398410  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01398410)
- NCT02847455  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02847455)
- NCT04215653  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04215653)
- NCT01408186  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01408186)
- NCT01805934  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01805934)
- NCT02767479  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02767479)
- NCT01954043  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01954043)

And 8 more, listed on the interactive page.

## Dosing

**Dose**

20mg

**Route**

Oral

**How often**

Once daily

### Conditions of use (2)

- Do not chew, crush or split tablets
- Swallow whole

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

1

**Polar surface area**

83.09

**Calculated partition coefficient (ALogP)**

2.99

**Calculated partition coefficient (XLogP)**

1.9

**Prodrug**

No

**Chirality**

Racemic

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

8

**Heavy atoms**

25

**Molecular formula**

C18H21N3O3S

**Monoisotopic mass**

359.13036271

**Natural product**

Yes

## Evidence counts

**Recorded assays**

1,044

**Active assays**

37

### Active assay types (2)

- Confirmatory
- Screening

## Pharmacologic actions

- Anti-Ulcer Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000897.html)
- Proton Pump Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D054328.html)

## Biological measurements

### Observed measurements

#### Solubility

**Median**

1,000,000

**Mean**

1,000,000

**Minimum**

1,000,000

**Maximum**

1,000,000

**Unit**

nM

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- Solubility

## Related records

### Trials (151)

- 14-day PCAB-based High-dose Dual Therapy and14-day PCAB-based Triple Therapy vs 14-day PPI-based Reverse Hybrid Therapy
- A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet
- A Bioequivalence Study of Idiazole 20mg DR Tabs and PARIET® 20 mg DR Tabs After a Single Oral Dose Administration Under Fasting Conditions in Healthy Adults
- A Bioequivalence Study of Rabeprazole From Idiazole 20mg DR Tabs (GSK, Egypt) and PARIET 20 mg DR Tabs (JANSSEN, EGYPT)
- A Clinical Trial of Anaprazole for Treating Reflux Esophagitis.
- [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md)
- A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes
- A Comparative Study on the Efficacy and Safety of E3810 in Patients With Non-erosive Gastroesophageal Reflux Disease
- A Double-blind Comparative Study of the Efficacy and Safety of E3810 10mg Once and Twice Daily in Maintenance Therapy for PPI Resistant Gastroesophageal Reflux Disease Patients
- A Drug-Drug Interaction Study of the Effect of Rabeprazole, Itraconazole or Fluconazole on the Pharmacokinetics of Vismodegib
- A Multiple Ascending High Dose Pharmacology Study of Anaprazole in Healthy Chinese Subjects
- A Pharmacokinetics (PK) Study of the Effects Rabeprazole and Rifampin on Dabrafenib in Subjects With BRAF V600 Mutation Positive Tumors
- A Phase 3 Randomised Controlled Trial to Evaluate Efficacy and Safety of Anaprazole in Patients With Duodenal Ulcers.
- A Pilot Cross-over Bioequivalence Study of E3810 for Healthy Japanese Male (Under Postprandial Condition)
- A Pilot Study of a 14-day Modified Sequential Therapy for Helicobacter Pylori Infection
- A Pilot Study To Investigate The Effect Of Concurrent Antacid Administration On The Bioavailability Of Six Experimental Formulations Of Palbociclib
- A Relative Bioavailability Study Evaluating Two New Encorafenib Formulations
- A Study of E3810 for Japanese Subjects With Functional Dyspepsia (SAMURAI Study: Suppression of Acid Milieu With Rabeprazole Improving Functional Dyspepsia ) (Study E3810-J081-204)
- A Study of Efficacy and Safety of "On-demand" Maintenance Therapy With Rabeprazole in Patients With Non-erosive Reflux Disease (NERD)
- A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis

### Approved for (3)

- [Bacterial infectious disease](https://trialight.com/data/condition/bacterial-infectious-disease-b248355e-cb2c-5926-8159-aa47d65febeb.md)
- [Gastroesophageal reflux disease](https://trialight.com/data/condition/gastroesophageal-reflux-disease-98b37c15-1154-58ee-9085-aa95708c220a.md)
- Peptic ulcer disease

### In development for (13)

- [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 1
- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 3
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 1
- Duodenal ulcer Phase 3
- Dyspepsia Phase 2
- [Helicobacter pylori infectious disease](https://trialight.com/data/condition/helicobacter-pylori-infectious-disease-ff5903ca-758b-5979-a633-075499e2938b.md) Phase 3
- [Infectious disease](https://trialight.com/data/condition/infectious-disease-dadc2591-65fc-5842-b510-cfbc295d8093.md) Phase 1
- Intrahepatic cholangiocarcinoma Phase 1
- Lymphoid neoplasm Phase 1
- [Lymphoma](https://trialight.com/data/condition/lymphoma-de4db685-7419-5e0e-b958-4591ffd69d43.md) Phase 1
- [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) Phase 1
- [Neoplasm](https://trialight.com/data/condition/neoplasm-2a973797-359b-5982-907e-98f9b7c1a284.md) Phase 1
- [Peptic esophagitis](https://trialight.com/data/condition/peptic-esophagitis-641e2fd4-029a-5edc-9799-717abc777592.md) Phase 3

### Other linked conditions (2)

- Calcium metabolic disease
- Gastric ulcer

### Targets (2)

- [ATP4A](https://trialight.com/data/target/atp4a-cb311620-cbd7-5592-86bf-6eff6bf5e70e.md) Potassium-transporting ATPase inhibitor
- [ATP4B](https://trialight.com/data/target/atp4b-dd74ece5-dac6-5730-bcb3-d26c200dd49f.md) Potassium-transporting ATPase inhibitor

---

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