> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/r-melphalan-7fbc2fe5-ce39-43af-8972-4e0d27151445
> Record changed: 2026-10-29

# (R)-melphalan

Highest phase reached

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 3

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

**Drug name**

(R)-melphalan

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

**Molecular weight**

305.21

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

**Structure (SMILES)**

N\[C@H\](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

### Other names (22)

- (r)-melphalan
- cb 3026
- CB-3026
- d melphalan
- d phenylalanine mustard
- d sarcolysine
- D-MELPHALAN
- D-PHENYLALANINE MUSTARD
- D-SARCOLYSINE
- medphalan
- MEDPHALAN
- MEDPHALAN \[IARC\]
- medphalan iarc
- melphalan d
- melphalan d form mi
- MELPHALAN D-FORM \[MI\]
- MELPHALAN, D-
- nsc 35051
- NSC-35051
- r melphalan
- sarcolysine d
- Sarcolysine, D-

## Identifiers

**CAS registry numbers**

- 13045-94-8

**ChEMBL ID**

CHEMBL250892

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

**InChIKey**

SGDBTWWWUNNDEQ-GFCCVEGCSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL250892)

**FDA ingredient codes (UNII)**

- 94H892992X

### PubChem compound IDs (2)

- 20189
- 6918991

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Investigated indications (2)

- **Condition**  
Sarcoma, Ewing

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000174

**Subject identifier**  
D012512
- **Condition**  
Multiple Myeloma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0001378

**Subject identifier**  
D009101

### Open Targets indications

- **Condition identifier**  
MONDO\_0009693

**Highest recorded phase**  
3

### Trial references (2)

- NCT00734877  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00734877)
- NCT02063022  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02063022)

## Chemical properties

**Hydrogen bond acceptors**

3

**Hydrogen bond donors**

2

**Polar surface area**

66.56

**Calculated partition coefficient (ALogP)**

1.93

**Calculated partition coefficient (XLogP)**

\-0.5

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

8

**Heavy atoms**

19

**Molecular formula**

C13H18Cl2N2O2

**Monoisotopic mass**

304.0745332

**Natural product**

Yes

## Evidence counts

**Recorded assays**

83

**Active assays**

6

### Active assay types (2)

- Confirmatory
- Other

## Biological measurements

### Observed measurements

#### Oral bioavailability

**Median**

71

**Mean**

71

**Minimum**

71

**Maximum**

71

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

## Related records

### Trials (187)

- \[11C\]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine
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### In development for (2)

- Ewing sarcoma Phase 3
- [Plasma cell myeloma](https://trialight.com/data/condition/plasma-cell-myeloma-37186689-2591-5775-9042-2f2bf046a2b5.md) Phase 3

---

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