> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394
> Record changed: 2026-10-13

# Quinidine

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

First approval year

1950

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

## Development status

**First approval year**

1950

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

**Drug name**

Quinidine

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

**Molecular weight**

324.42

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

**Structure (SMILES)**

C=C\[C@H\]1CN2CC\[C@H\]1C\[C@@H\]2\[C@@H\](O)c1ccnc2ccc(OC)cc12

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

### Other names (35)

- .beta.-quinidine
- (+)-QUINIDINE
- (8r,9s)-quinidine
- 8r 9s quinidine
- beta quinidine
- cinchonan 9 ol 6 methoxy 9s
- CINCHONAN-9-OL, 6'-METHOXY-, (9S)-
- conquinine
- Conquinine
- kinidin
- Kinidin
- pitayine
- Pitayine
- quinidine
- Quinidine
- QUINIDINE \[HSDB\]
- QUINIDINE \[MART.\]
- QUINIDINE \[MI\]
- QUINIDINE \[VANDF\]
- Quinidine \[WHO-DD\]
- quinidine hsdb
- quinidine mart
- quinidine mi
- quinidine vandf
- quinidine who dd

And 10 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 56-54-2

**ChEMBL ID**

CHEMBL1294

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

**InChIKey**

LOUPRKONTZGTKE-LHHVKLHASA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

**PubChem compound IDs**

- 441074

**FDA ingredient codes (UNII)**

- ITX08688JL

### ATC classification codes (3)

- C01BA01
- C01BA51
- C01BA71

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1294)

### RxNorm IDs (RxCUI) (2)

- 9068
- 35220

## Regulatory information

### United States

**Applicant**

LILLY

**Approval date**

12 Jul 1950

**Application number**

NDA007529

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

**Availability**

Prescription only

**Boxed warning**

Yes

## Pharmacology

### Drug classification

**Pharmacology name**

quinidine

**Type**

Natural product

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral
- Parenteral

### Mechanisms of action (10)

- **Action**  
Antagonist

**Action type**  
Antagonist

**Target**  
KNa1.1

**Gene symbol**  
KCNT1

**Protein identifier**  
Q5JUK3
- **Action**  
Channel blocker

**Action type**  
Channel blocker

**Target**  
VRAC

**Gene symbol**  
VRAC
- **Action**  
Channel blocker

**Action type**  
Channel blocker

**Target**  
KCa5.1

**Gene symbol**  
KCNU1

**Protein identifier**  
A8MYU2
- **Action**  
Channel blocker

**Action type**  
Channel blocker

**Target**  
Kv10.1

**Gene symbol**  
KCNH1

**Protein identifier**  
O95259

**Median affinity**

5.8

**Affinity units**  
pIC50
- **Action**  
Channel blocker

**Action type**  
Channel blocker

**Target**  
K2P5.1

**Gene symbol**  
KCNK5

**Protein identifier**  
O95279
- **Action**  
Channel blocker

**Action type**  
Channel blocker

**Target**  
Kv1.5

**Gene symbol**  
KCNA5

**Protein identifier**  
P22460

**Median affinity**

5.2

**Affinity units**  
pKd
- **Action**  
Channel blocker

**Action type**  
Channel blocker

**Target**  
Kv1.7

**Gene symbol**  
KCNA7

**Protein identifier**  
Q96RP8

**Median affinity**

4.8

**Affinity units**  
pKd
- **Action**  
Channel blocker

**Action type**  
Channel blocker

**Target**  
K2P16.1

**Gene symbol**  
KCNK16

**Protein identifier**  
Q96T55
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Plasma membrane monoamine transporter

**Gene symbol**  
SLC29A4

**Protein identifier**  
Q7RTT9

**Median affinity**

4.6

**Affinity units**  
pKi
- **Action**  
Pore blocker

**Action type**  
PORE\_BLOCKER

**Target**  
Kv10.2

**Gene symbol**  
KCNH5

**Protein identifier**  
Q8NCM2

**Median affinity**

3.8

**Affinity units**  
pIC50

### Open Targets mechanisms

- **Mechanism**  
Sodium channel alpha subunit blocker

**Action type**  
Blocker

**Target**  
Sodium channel alpha subunit

### DrugCentral mechanisms (7)

- **Action type**  
Blocker

**Gene symbol**  
KCNH1

**Protein identifier**  
O95259

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Blocker

**Gene symbol**  
KCNA5

**Protein identifier**  
P22460

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Blocker

**Gene symbol**  
SCN1A|SCN2A|SCN3A

**Protein identifier**  
P35498|Q99250|Q9NY46

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Blocker

**Gene symbol**  
SCN5A

**Protein identifier**  
Q14524

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Blocker

**Gene symbol**  
KCNA7

**Protein identifier**  
Q96RP8

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Inhibitor

**Gene symbol**  
CYP2D6

**Protein identifier**  
P10635

**Organism**  
Homo sapiens

**Target development level**  
Clinical
- **Action type**  
Inhibitor

**Gene symbol**  
SLC29A4

**Protein identifier**  
Q7RTT9

**Organism**  
Homo sapiens

**Target development level**  
Biological evidence

### Investigated indications (15)

- **Condition**  
Atrial Fibrillation

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000275

**Subject identifier**  
D001281
- **Condition**  
Myocardial Infarction

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000612

**Subject identifier**  
D009203
- **Condition**  
Hepatitis B, Chronic

**Highest recorded phase**  
1

**Condition identifier**  
EFO:0004197

**Subject identifier**  
D019694
- **Condition**  
Arrhythmias, Cardiac

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0004269

**Subject identifier**  
D001145
- **Condition**  
Death, Sudden, Cardiac

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004278

**Subject identifier**  
D016757
- **Condition**  
Ventricular Fibrillation

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0004287

**Subject identifier**  
D014693
- **Condition**  
Non-alcoholic Fatty Liver Disease

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001249

**Subject identifier**  
D065626
- **Condition**  
Respiratory Syncytial Virus Infections

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1001413

**Subject identifier**  
D018357
- **Condition**  
Constipation

**Highest recorded phase**  
1

**Condition identifier**  
HP:0002019

**Subject identifier**  
D003248
- **Condition**  
Depressive Disorder, Major

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002009

**Subject identifier**  
D003865
- **Condition**  
Depressive Disorder

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0002050

**Subject identifier**  
D003866
- **Condition**  
Amyotrophic Lateral Sclerosis

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0004976

**Subject identifier**  
D000690
- **Condition**  
Migraine Disorders

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005277

**Subject identifier**  
D008881
- **Condition**  
Multiple Sclerosis

**Highest recorded phase**  
3

**Condition identifier**  
MONDO:0005301

**Subject identifier**  
D009103
- **Condition**  
Severe Acute Respiratory Syndrome

**Highest recorded phase**  
1

**Condition identifier**  
MONDO:0100096

**Subject identifier**  
D045169

### Open Targets indications (25)

- **Condition identifier**  
EFO\_0004197

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_0004269
- **Condition identifier**  
EFO\_0004269

**Highest recorded phase**  
4
- **Condition identifier**  
EFO\_0005762

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1000783

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_1001249

**Highest recorded phase**  
1
- **Condition identifier**  
HP\_0000713

**Highest recorded phase**  
2
- **Condition identifier**  
HP\_0000737

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0001699

**Highest recorded phase**  
3
- **Condition identifier**  
HP\_0002019

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0000190

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0002009

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002009

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0002050

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004975

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0004976

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0004981

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005180

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005277

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005301

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005301

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005477

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0006626

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008222

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0100234

**Highest recorded phase**  
2

### Open Targets warnings

- **Warning**  
Black Box Warning

**Effect**  
cardiotoxicity

**Country**  
United States

### Reported adverse events (17)

- **Event**  
atrioventricular block

**Reports**  
7

**Reporting signal score**

25.0005
- **Event**  
blood ketone body decreased

**Reports**  
1

**Reporting signal score**

7.45954
- **Event**  
brugada syndrome

**Reports**  
3

**Reporting signal score**

13.828
- **Event**  
cerebral malaria

**Reports**  
1

**Reporting signal score**

7.3542
- **Event**  
cyp2d6 polymorphism

**Reports**  
1

**Reporting signal score**

7.09191
- **Event**  
drug hypersensitivity

**Reports**  
18

**Reporting signal score**

24.7978
- **Event**  
drug-genetic interaction

**Reports**  
1

**Reporting signal score**

7.45954
- **Event**  
electrocardiogram qrs complex prolonged

**Reports**  
4

**Reporting signal score**

13.6101
- **Event**  
electrocardiogram qt prolonged

**Reports**  
31

**Reporting signal score**

109.477
- **Event**  
haemoglobinuria

**Reports**  
2

**Reporting signal score**

9.3966
- **Event**  
long qt syndrome

**Reports**  
3

**Reporting signal score**

11.2651
- **Event**  
multiple-drug resistance

**Reports**  
4

**Reporting signal score**

16.3343
- **Event**  
ototoxicity

**Reports**  
2

**Reporting signal score**

7.08267
- **Event**  
seizure

**Reports**  
6

**Reporting signal score**

7.62338
- **Event**  
status epilepticus

**Reports**  
4

**Reporting signal score**

10.2399
- **Event**  
treatment failure

**Reports**  
8

**Reporting signal score**

13.4192
- **Event**  
ventricular tachycardia

**Reports**  
4

**Reporting signal score**

8.73092

### Trial references (15)

- NCT00000464  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000464)
- NCT00000556  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000556)
- NCT00789165  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00789165)
- NCT00021697  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00021697)
- NCT03883581  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03883581)
- NCT00050232  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00050232)
- NCT01460381  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01460381)
- NCT01882829  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01882829)
- NCT01533155  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01533155)
- NCT02153502  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02153502)
- NCT02176018  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02176018)
- NCT03610945  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03610945)
- NCT03755778  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03755778)
- NCT04783753  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04783753)
- NCT05594602  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05594602)

## Dosing

**Dose**

1 capsule, then 1 capsule every 12 hours

**Route**

Oral

**How often**

Once daily for 7 days, then twice daily after 7 days

## Chemical properties

**Hydrogen bond acceptors**

4

**Hydrogen bond donors**

1

**Polar surface area**

45.59

**Calculated partition coefficient (ALogP)**

3.17

**Calculated partition coefficient (XLogP)**

2.9

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

4

**Heavy atoms**

24

**Molecular formula**

C20H24N2O2

**Monoisotopic mass**

324.183778013

**Natural product**

Yes

## Evidence counts

**Recorded assays**

4,147

**Active assays**

224

### Active assay types (4)

- Confirmatory
- Other
- Screening
- Summary

## Pharmacologic actions

- Adrenergic alpha-Antagonists  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000317.html)
- Anti-Arrhythmia Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000889.html)
- Antimalarials  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000962.html)
- Enzyme Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D004791.html)
- Muscarinic Antagonists  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018727.html)
- Voltage-Gated Sodium Channel Blockers  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D061567.html)
- Cytochrome P-450 CYP2D6 Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D065690.html)

## Biological measurements

These details could not be displayed.

## Related records

### Trials (24)

- A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
- A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants
- A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323.
- [A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers](https://trialight.com/data/trial/a-single-and-multiple-ascending-doses-relative-e765be29-f034-4382-84c2-075c49a7d226.md)
- A Study of Imlunestrant (LY3484356) in Female Healthy Participants
- A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants
- A Study to Evaluate the Effect of Genotype on LY2216684
- A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants.
- A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine
- Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
- Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
- Drug-Drug Interaction Study Between EDP-235, Itraconazole, Carbamazepine and Quinidine in Healthy Subjects.
- Drug-drug Interaction Study Between EDP-305, Fluconazole and Quinidine in Healthy Volunteers
- Drug-Drug Interaction Study Between EDP-514, Itraconazole, Carbamazepine, and Quinidine in Healthy Subjects
- Drug-Drug Interaction Study Between EDP-938, Itraconazole, Rifampin, and Quinidine in Healthy Subjects
- Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males
- Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM)
- Empiric Quinidine for Asymptomatic Brugada Syndrome
- Evaluating the Efficacy of Dextromethorphan/Quinidine in Treating Irritability in Huntington's Disease
- Nuedexta for the Prevention and Modification of Disease Progression in Episodic Migraine

### Approved for (1)

- Cardiac rhythm disease

### In development for (15)

- [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 3
- [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 3
- Constipation disorder Phase 1
- [COVID-19](https://trialight.com/data/condition/covid-19-13f0ebf3-c291-557d-bdef-93563d077103.md) Phase 1
- [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Phase 2
- Diabetic neuropathy Phase 2
- [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md) Phase 1
- [Major depressive disorder](https://trialight.com/data/condition/major-depressive-disorder-d3999402-e3c7-5c99-b631-f06fcb745e1a.md) Phase 2
- [Metabolic dysfunction-associated steatohepatitis](https://trialight.com/data/condition/metabolic-dysfunction-associated-steatohepatitis-05fad825-0fff-55c9-8746-0cb406b65c65.md) Phase 1
- [Migraine disorder](https://trialight.com/data/condition/migraine-disorder-0a28e77d-6415-5582-980f-2d0721f95f76.md) Phase 2
- [Multiple sclerosis](https://trialight.com/data/condition/multiple-sclerosis-62806c95-fe1b-529e-bd16-95cb92d15375.md) Phase 3
- [Myocardial infarction](https://trialight.com/data/condition/myocardial-infarction-b4e97483-7435-5701-81dc-26d955e420ec.md) Phase 3
- [Respiratory syncytial virus infectious disease](https://trialight.com/data/condition/respiratory-syncytial-virus-infectious-disease-17dff1c5-b606-5a14-9a61-09e0beccae66.md) Phase 1
- Sudden cardiac arrest Phase 3
- Ventricular fibrillation Phase 3

### Targets (10)

- [SCN10A](https://trialight.com/data/target/scn10a-e64e3928-416a-5e6d-b348-81c46298a289.md) Sodium channel alpha subunit blocker
- [SCN11A](https://trialight.com/data/target/scn11a-e3013f04-1b7e-5769-85f7-a85f520126d6.md) Sodium channel alpha subunit blocker
- [SCN1A](https://trialight.com/data/target/scn1a-3473d408-b191-588e-8a54-6ea744fc0b86.md) Sodium channel alpha subunit blocker
- [SCN2A](https://trialight.com/data/target/scn2a-58945297-e1b4-5bf0-977c-fff5460c4bc5.md) Sodium channel alpha subunit blocker
- [SCN3A](https://trialight.com/data/target/scn3a-312e048c-0a82-5193-94d1-473a98b97a6e.md) Sodium channel alpha subunit blocker
- [SCN4A](https://trialight.com/data/target/scn4a-49bb6125-30fd-58f5-8275-868382aee1cb.md) Sodium channel alpha subunit blocker
- [SCN5A](https://trialight.com/data/target/scn5a-b122849c-977b-5d4c-a790-0245f1654eb5.md) Sodium channel alpha subunit blocker
- [SCN7A](https://trialight.com/data/target/scn7a-8f79dda4-d450-5e5e-ade8-304fdd8afea0.md) Sodium channel alpha subunit blocker
- [SCN8A](https://trialight.com/data/target/scn8a-05beb79a-ca39-5d8d-a99b-ee0fd0d5e8c4.md) Sodium channel alpha subunit blocker
- [SCN9A](https://trialight.com/data/target/scn9a-6d55e0b8-9c24-5570-a1c0-5445020a13bf.md) Sodium channel alpha subunit blocker

---

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