> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/quemliclustat-bf22144a-7270-4d57-8258-cef1e916a241
> Record changed: 2026-10-13

# Quemliclustat

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

**Drug name**

Quemliclustat

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

**Molecular weight**

580.83

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

**Structure (SMILES)**

C\[C@H\](Nc1cc(Cl)nc2c1cnn2\[C@@H\]1O\[C@H\](COP(=O)(O)CP(=O)(O)O)\[C@@H\](O)\[C@H\]1O)c1ccccc1F

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

### Other names (16)

- ab 680
- AB-680
- ab680
- Ab680
- AB680
- compound 55
- COMPOUND 55
- quemliclustat
- Quemliclustat
- QUEMLICLUSTAT
- quemliclustat \[INN\]
- QUEMLICLUSTAT \[USAN\]
- Quemliclustat \[WHO-DD\]
- quemliclustat inn
- quemliclustat usan
- quemliclustat who dd

## Identifiers

**CAS registry numbers**

- 2105904-82-1

**ChEMBL ID**

CHEMBL4471306

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

**InChIKey**

MFYLCAMJNGIULC-KCVUFLITSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4471306)

**PubChem compound IDs**

- 130205852

**FDA ingredient codes (UNII)**

- J6K8WSV73A

## Regulatory information

### Other regulatory facts

**Patents**

0

**Designations**

1

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

## Pharmacology

### Drug classification

**Pharmacology name**

quemliclustat

**Type**

Synthetic organic

**Drug name stem**

\-stat

### Mechanisms of action

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Ecto-5'-Nucleotidase

**Gene symbol**  
NT5E

**Protein identifier**  
P21589

**Median affinity**

11.3

**Affinity units**  
pKi

### Investigated indications (8)

- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000196

**Subject identifier**  
D011471
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000616

**Subject identifier**  
D009369
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000673

**Subject identifier**  
D011471
- **Condition**  
Cholangiocarcinoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0005221

**Subject identifier**  
D018281
- **Condition**  
Pancreatic Neoplasms

**Highest recorded phase**  
1

**Condition identifier**  
EFO:1000359

**Subject identifier**  
D010190
- **Condition**  
Neoplasms

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0004992

**Subject identifier**  
D009369
- **Condition**  
Carcinoma, Pancreatic Ductal

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005184

**Subject identifier**  
D021441
- **Condition**  
Carcinoma, Non-Small-Cell Lung

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005233

**Subject identifier**  
D002289

### Open Targets indications (15)

- **Condition identifier**  
EFO\_0000196

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0003860

**Highest recorded phase**  
1
- **Condition identifier**  
EFO\_1000359

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0003060

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0003219

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005028

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005036

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005070
- **Condition identifier**  
MONDO\_0005184

**Highest recorded phase**  
3
- **Condition identifier**  
MONDO\_0005233

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005575

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0006047

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0008315

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0009831

**Highest recorded phase**  
1

### Trial references (8)

- NCT04104672  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04104672)
- NCT04381832  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04381832)
- NCT05329766  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05329766)
- NCT05676931  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05676931)
- NCT05688215  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05688215)
- NCT06048484  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06048484)
- NCT05915442  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05915442)
- NCT06048133  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06048133)

## Chemical properties

**Hydrogen bond acceptors**

10

**Hydrogen bond donors**

6

**Polar surface area**

196.49

**Calculated partition coefficient (ALogP)**

2.35

**Calculated partition coefficient (XLogP)**

\-0.7

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

2

**Rotatable bonds**

9

**Heavy atoms**

37

**Molecular formula**

C20H24ClFN4O9P2

**Monoisotopic mass**

580.0691082

**Natural product**

No

## Evidence counts

**Recorded assays**

80

**Active assays**

18

### Active assay types

- Confirmatory

## Pharmacologic actions

- Immune Checkpoint Inhibitors  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000082082.html)

## Related records

### Trials (14)

- [A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies](https://trialight.com/data/trial/a-safety-and-efficacy-study-of-treatment-combinations-with-3f4b398e-ad9f-4d15-84a8-5055bc61e278.md)
- A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies
- A Study to Investigate the Pharmacokinetic Profile of Oral AB680 in Healthy Volunteers
- A Study to Investigate the Safety of AB680 in Healthy Volunteers
- Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer
- Adenosine Signaling Modulation and Immune Checkpoint Inhibition With Hormone Sensitive Oligometastatic Prostate Cancer
- An Open Label Study Evaluating the Efficacy and Safety of Etrumadenant (AB928) Based Treatment Combinations in Participants With Metastatic Colorectal Cancer.
- Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma
- Enfortumab Vedotin, Pembrolizumab and Quemliclustat for the Treatment of Unresectable Locally Advanced and Metastatic Urothelial Cancer
- Metabolism, Excretion, and Mass Balance Study of Quemliclustat in Healthy Adult Participants (ARC-24)
- Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers (QUIC)
- Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
- [Study With Various Immunotherapy Treatments in Participants With Lung Cancer](https://trialight.com/data/trial/study-with-various-immunotherapy-treatments-in-participants-b82162b7-88f5-4d28-aa34-a74740ae72c8.md)
- Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma

### In development for (9)

- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 2
- [Cholangiocarcinoma](https://trialight.com/data/condition/cholangiocarcinoma-3777afe4-5189-5eb1-82f8-0c3446cb902f.md) Phase 2
- [Malignant pancreatic neoplasm](https://trialight.com/data/condition/malignant-pancreatic-neoplasm-5dd0b53e-5962-50ea-a2e5-cf2444bd0485.md) Phase 1
- [Metastatic prostate carcinoma](https://trialight.com/data/condition/metastatic-prostate-carcinoma-d5fb1084-bad5-5db6-8240-897dc47ea451.md) Phase 2
- Neoplasm Phase 2
- [Non-small cell lung carcinoma](https://trialight.com/data/condition/non-small-cell-lung-carcinoma-a86c1d60-523f-5ea7-a5e1-39ed4a2296f8.md) Phase 2
- [Pancreatic ductal adenocarcinoma](https://trialight.com/data/condition/pancreatic-ductal-adenocarcinoma-77c1c5a8-638b-51d0-b18e-2c881b8902e5.md) Phase 2
- [Pancreatic neoplasm](https://trialight.com/data/condition/pancreatic-neoplasm-de300cc3-339a-5c06-97d8-2d9155fc3a7b.md) Phase 1
- [Prostate adenocarcinoma](https://trialight.com/data/condition/prostate-adenocarcinoma-84e3e3af-1ae1-5760-8157-8d9fc0cff608.md) Phase 2

---

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