> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/propofol-11b6d3dc-8bdb-4f05-a143-ae26c38c4af2 > Record changed: 2026-10-13 # Propofol Highest phase reached Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) First approval year 1989 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) ## Development status **First approval year** 1989 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) **Listing at source** Listed **Highest phase reached** Approved Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) **Drug name** Propofol Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) **Molecular weight** 178.27 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) **Structure (SMILES)** CC(C)c1cccc(C(C)C)c1O Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) ### Brand names (10) - diprivan - Diprivan - disoprivan - Disoprivan - propofol - Propofol - propofol component of ketafol - Propofol component of ketafol - rapinovet - Rapinovet ### Other names (84) - Arm I (Propofol) - arm i propofol - Diprivan - disoprofol - Disoprofol - Drug-Induced Sleep Endoscopy (Propofol) - fresofol - Fresofol - ici 35 868 - ICI 35-868 - ICI 35,868 - ici 35868 - ICI-35868 - ici35 868 - ICI35,868 - Injection Propofol - ketafol component propofol - KETAFOL COMPONENT PROPOFOL - lipuro - Lipuro - nsc 5105 - NSC-5105 - phenol 2 6 bis 1 methylethyl - Phenol, 2,6-bis(1-methylethyl) - propofol And 59 more, listed on the interactive page. ## Identifiers **ATC classification codes** - N01AX10 Sources for recorded values Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) **CAS registry numbers** - 2078-54-8 **ChEMBL ID** CHEMBL526 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) **InChIKey** OLBCVFGFOZPWHH-UHFFFAOYSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL526) **PubChem compound IDs** - 4943 **RxNorm IDs (RxCUI)** - 8782 **FDA ingredient codes (UNII)** - YI7VU623SF ## Regulatory information ### United States **Applicant** FRESENIUS KABI USA **Approval date** 2 Oct 1989 **Application number** NDA019627 ### Other regulatory facts **First in class** No **Orphan designation** No **Availability** Prescription only ## Pharmacology ### Drug classification **Pharmacology name** propofol **Type** Synthetic organic **Approval recorded by Guide to Pharmacology** Yes #### Administration routes - Parenteral ### Mechanisms of action (19) - **Action** Inhibition **Action type** Inhibitor **Target** Piezo1 **Gene symbol** PIEZO1 **Protein identifier** Q92508 - **Action** Inhibition **Action type** Inhibitor **Target** Piezo2 **Gene symbol** PIEZO2 **Protein identifier** Q9H5I5 - **Action** Inhibition **Action type** Inhibitor **Target** TRPV4 **Gene symbol** TRPV4 **Protein identifier** Q9HBA0 **Median affinity** 4.41 **Affinity units** pIC50 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** O00591 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** O14764 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P14867 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P18505 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P18507 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P28472 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P31644 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P34903 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P47869 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P47870 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P48169 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** P78334 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q16445 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q8N1C3 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q99928 - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE\_ALLOSTERIC\_MODULATOR **Target** GABA-A receptor; anion channel **Protein identifier** Q9UN88 ### Open Targets mechanisms - **Mechanism** GABA-A receptor; anion channel positive allosteric modulator **Action type** POSITIVE ALLOSTERIC MODULATOR **Target** GABA-A receptor; anion channel ### DrugCentral mechanisms (3) - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA1|GABRG2|GABRB3 **Protein identifier** P14867|P18507|P28472 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRA1|GABRG2|GABRB2 **Protein identifier** P14867|P18507|P47870 **Organism** Homo sapiens **Target development level** Clinical - **Action type** POSITIVE ALLOSTERIC MODULATOR **Gene symbol** GABRG2|GABRA2|GABRB2 **Protein identifier** P18507|P47869|P47870 **Organism** Homo sapiens **Target development level** Clinical ### Investigated indications (58) - **Condition** Atrial Fibrillation **Highest recorded phase** 3 **Condition identifier** EFO:0000275 **Subject identifier** D001281 - **Condition** Hypertension **Highest recorded phase** 3 **Condition identifier** EFO:0000537 **Subject identifier** D006973 - **Condition** Wounds and Injuries **Highest recorded phase** 2 **Condition identifier** EFO:0000546 **Subject identifier** D014947 - **Condition** Leukemia **Highest recorded phase** 2 **Condition identifier** EFO:0000565 **Subject identifier** D007938 - **Condition** Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0000616 **Subject identifier** D009369 - **Condition** Adenomatous Polyposis Coli **Highest recorded phase** 3 **Condition identifier** EFO:0000662 **Subject identifier** D011125 - **Condition** Severe Acute Respiratory Syndrome **Highest recorded phase** 3 **Condition identifier** EFO:0000694 **Subject identifier** D045169 - **Condition** Stroke **Highest recorded phase** 3 **Condition identifier** EFO:0000712 **Subject identifier** D020521 - **Condition** Subarachnoid Hemorrhage **Highest recorded phase** 3 **Condition identifier** EFO:0000713 **Subject identifier** D013345 - **Condition** Obesity **Highest recorded phase** 3 **Condition identifier** EFO:0001073 **Subject identifier** D009765 - **Condition** Obesity, Morbid **Highest recorded phase** 2 **Condition identifier** EFO:0001074 **Subject identifier** D009767 - **Condition** Liver Cirrhosis **Highest recorded phase** 3 **Condition identifier** EFO:0001422 **Subject identifier** D008103 - **Condition** Coronary Disease **Highest recorded phase** 2 **Condition identifier** EFO:0001645 **Subject identifier** D003327 - **Condition** Pancreatic Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0002618 **Subject identifier** D010190 - **Condition** Reperfusion Injury **Highest recorded phase** 3 **Condition identifier** EFO:0002687 **Subject identifier** D015427 - **Condition** Heart Diseases **Highest recorded phase** 3 **Condition identifier** EFO:0003777 **Subject identifier** D006331 - **Condition** Pain **Highest recorded phase** 3 **Condition identifier** EFO:0003843 **Subject identifier** D010146 - **Condition** Intestinal Polyps **Highest recorded phase** 2 **Condition identifier** EFO:0003855 **Subject identifier** D007417 - **Condition** Breast Neoplasms **Highest recorded phase** 3 **Condition identifier** EFO:0003869 **Subject identifier** D001943 - **Condition** Intracranial Aneurysm **Highest recorded phase** 3 **Condition identifier** EFO:0003870 **Subject identifier** D002532 - **Condition** Renal Insufficiency, Chronic **Highest recorded phase** 1 **Condition identifier** EFO:0003884 **Subject identifier** D051436 - **Condition** Premature Birth **Highest recorded phase** 1 **Condition identifier** EFO:0003917 **Subject identifier** D047928 - **Condition** Sleep Apnea, Obstructive **Highest recorded phase** 2 **Condition identifier** EFO:0003918 **Subject identifier** D020181 - **Condition** Osteonecrosis **Highest recorded phase** 0.5 **Condition identifier** EFO:0004259 **Subject identifier** D010020 - **Condition** Scoliosis **Highest recorded phase** 1 **Condition identifier** EFO:0004273 **Subject identifier** D012600 And 33 more, listed on the interactive page. ### Open Targets indications (204) - **Condition identifier** EFO\_0000217 - **Condition identifier** EFO\_0000246 - **Condition identifier** EFO\_0000266 - **Condition identifier** EFO\_0000275 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000537 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000565 - **Condition identifier** EFO\_0000616 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000662 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000712 **Highest recorded phase** 3 - **Condition identifier** EFO\_0000713 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001072 **Highest recorded phase** 1 - **Condition identifier** EFO\_0001073 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001074 - **Condition identifier** EFO\_0001422 **Highest recorded phase** 3 - **Condition identifier** EFO\_0001645 **Highest recorded phase** 3 - **Condition identifier** EFO\_0002687 **Highest recorded phase** 3 - **Condition identifier** EFO\_0002950 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003776 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003777 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003818 - **Condition identifier** EFO\_0003855 **Highest recorded phase** 2 - **Condition identifier** EFO\_0003869 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003870 **Highest recorded phase** 3 - **Condition identifier** EFO\_0003884 **Highest recorded phase** 1 - **Condition identifier** EFO\_0003917 **Highest recorded phase** 1 And 179 more, listed on the interactive page. ### Reported adverse events (54) - **Event** agitation **Reports** 178 **Reporting signal score** 112.828 - **Event** airway complication of anaesthesia **Reports** 35 **Reporting signal score** 145.797 - **Event** anaesthetic complication **Reports** 66 **Reporting signal score** 166.789 - **Event** anaphylactic reaction **Reports** 486 **Reporting signal score** 754.843 - **Event** anaphylactic shock **Reports** 847 **Reporting signal score** 2,518.49 - **Event** anaphylactoid shock **Reports** 33 **Reporting signal score** 106.008 - **Event** arthralgia **Reports** 12 **Reporting signal score** 139.302 - **Event** blood pressure decreased **Reports** 164 **Reporting signal score** 132.279 - **Event** bradycardia **Reports** 337 **Reporting signal score** 358.721 - **Event** bronchospasm **Reports** 324 **Reporting signal score** 766.447 - **Event** cardiac arrest **Reports** 335 **Reporting signal score** 612.988 - **Event** cardio-respiratory arrest **Reports** 98 **Reporting signal score** 170.393 - **Event** circulatory collapse **Reports** 192 **Reporting signal score** 387.436 - **Event** delayed recovery from anaesthesia **Reports** 114 **Reporting signal score** 460.565 - **Event** diabetes insipidus **Reports** 46 **Reporting signal score** 104.465 - **Event** diarrhoea **Reports** 30 **Reporting signal score** 223.819 - **Event** dizziness **Reports** 52 **Reporting signal score** 108.664 - **Event** dystonia **Reports** 89 **Reporting signal score** 110.033 - **Event** electrocardiogram st segment elevation **Reports** 59 **Reporting signal score** 116.763 - **Event** fall **Reports** 11 **Reporting signal score** 131.428 - **Event** fatigue **Reports** 45 **Reporting signal score** 210.791 - **Event** generalised erythema **Reports** 79 **Reporting signal score** 144.184 - **Event** haemodynamic instability **Reports** 99 **Reporting signal score** 213.911 - **Event** headache **Reports** 65 **Reporting signal score** 124.956 - **Event** hyperthermia malignant **Reports** 162 **Reporting signal score** 650.429 And 29 more, listed on the interactive page. ### Trial references (81) - NCT00142493 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00142493) - NCT00187135 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00187135) - NCT00436345 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00436345) - NCT01342835 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01342835) - NCT01387139 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01387139) - NCT02203175 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02203175) - NCT03841812 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03841812) - NCT04062123 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04062123) - NCT04947345 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04947345) - NCT05486819 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05486819) - NCT06034873 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06034873) - NCT00209521 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00209521) - NCT01948765 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01948765) - NCT00265616 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00265616) - NCT00336882 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00336882) - NCT00538616 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00538616) - NCT01007773 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01007773) - NCT04034771 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04034771) - NCT00337051 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00337051) - NCT00389883 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00389883) - NCT00418457 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00418457) - NCT00478907 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00478907) - NCT00671931 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00671931) - NCT00695214 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00695214) - NCT05303987 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05303987) And 56 more, listed on the interactive page. ## Dosing **Route** Intravenous ### Conditions of use (3) - Discard unused after 28 days - Use aseptic technique - Use within 28 days after opening ## Chemical properties **Hydrogen bond acceptors** 1 **Hydrogen bond donors** 1 **Polar surface area** 20.23 **Calculated partition coefficient (ALogP)** 3.64 **Calculated partition coefficient (XLogP)** 3.8 **Prodrug** No **Chirality** Achiral **Inorganic** No **Rule-of-five violations** 0 **Rotatable bonds** 2 **Heavy atoms** 13 **Molecular formula** C12H18O **Monoisotopic mass** 178.135765193 **Natural product** Yes ## National Drug Codes - 0069-0209 - 0069-0234 - 0069-0248 - 0409-0010 - 0409-0501 - 0409-1511 - 0409-4699 - 0409-6010 - 0641-6194 - 0641-6195 - 0641-6196 - 16714-528 - 16714-690 - 16714-977 - 23155-345 - 25021-608 - 43598-265 - 43598-548 - 43598-549 - 63323-269 - 65219-800 - 71288-729 - 71288-730 - 71288-731 - 72572-590 And 10 more, listed on the interactive page. ## Evidence counts **Recorded assays** 3,799 **Active assays** 172 ### Active assay types (4) - Confirmatory - Other - Screening - Summary ## Pharmacologic actions - Hypnotics and Sedatives Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D006993.html) - Anesthetics, Intravenous Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018686.html) ## Biological measurements These details could not be displayed. ## Related records ### Trials (1,327) - "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail - A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation - A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery - A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy - A Clinical Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion in Elective Surgery Patients - A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor - A Comparative Study of Depth of Anesthesia Monitored by Bispectral Index (BIS) Values - A Comparative Study of Eleveld and Schnider Pharmacokinetic Models for Target-Controlled Infusion of Propofol in Sedation of Mechanically Ventilated ICU Patients - A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients - A Comparison Between Propofol-Remifentanil and Midazolam-Remifentanil Sedation in the Intensive Care Unit - A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation - A Comparison of Efficacy and Safety During Endoscopic Submucosal Dissection Between Dexmedetomidine-remifentanil and Propofol-remifentanil - A Comparison of Injection Pain of Propofol During Endoscopy : LCT Propofol vs MCT/LCT Propofol - A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters - A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation - A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Renal Protection During Deceased Brain Dead Donor Kidney Transplantation - A Prospective, Randomized Trial - A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy - A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial - A Comparison of the Sedation During Endoscopy in Children - A Comparison of Totally Intravenous and Inhalation Anesthesia for Intraocular Pressure During Robot-Assisted Laparoscopic Radical Prostatectomy ### In development for (47) - [Acute respiratory distress syndrome](https://trialight.com/data/condition/acute-respiratory-distress-syndrome-8dc4b74c-8356-5dfd-bfa3-258d9d1e44ab.md) Phase 3 - [Atrial fibrillation](https://trialight.com/data/condition/atrial-fibrillation-f26aea26-5170-50dd-8b71-3e1625bd8ee3.md) Phase 3 - Brain aneurysm Phase 3 - Brain injury Phase 3 - [Breast neoplasm](https://trialight.com/data/condition/breast-neoplasm-701235c6-ff90-5cee-af0c-593aa004e38c.md) Phase 3 - [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md) Phase 3 - Cerebral arterial disease Phase 3 - [Chronic kidney disease](https://trialight.com/data/condition/chronic-kidney-disease-dc1fecbb-338b-5bbc-8d68-08e49db49918.md) Phase 1 - [Cirrhosis of liver](https://trialight.com/data/condition/cirrhosis-of-liver-d90e4a84-9e82-54fc-a553-1e42086e8382.md) Phase 3 - Colon adenocarcinoma Phase 2 - [Colorectal cancer](https://trialight.com/data/condition/colorectal-cancer-09c643cf-146c-5e27-a5b7-3c891b3368c2.md) Phase 1 - [Coronary artery disorder](https://trialight.com/data/condition/coronary-artery-disorder-6f736849-d477-587a-b3fa-b0621d573407.md) Phase 2 - Delirium Phase 3 - [Depressive disorder](https://trialight.com/data/condition/depressive-disorder-7618feda-3f90-5521-94e1-99f7100e8324.md) Early phase 1 - Dissociative amnesia Phase 1 - [Esophageal cancer](https://trialight.com/data/condition/esophageal-cancer-a3b5271c-e6d4-537b-8dfd-9391c60e2af2.md) Phase 3 - Exocrine pancreatic carcinoma Phase 3 - Heart disorder Phase 3 - [Hypertensive disorder](https://trialight.com/data/condition/hypertensive-disorder-6d786557-b9e8-5afc-80f3-89a1995f9da5.md) Phase 3 - Hypotensive disorder Phase 2 ### Other linked conditions (9) - [Breast cancer](https://trialight.com/data/condition/breast-cancer-8ac10da3-93bd-54c5-a93b-265bc6699689.md) - Cerebral palsy - Childhood acute lymphoblastic leukemia - Cognitive disorder - Gastritis - [Lung disorder](https://trialight.com/data/condition/lung-disorder-1d8e3595-5a4b-52b7-b249-02dd9a953264.md) - Metabolic acidosis - Pain agnosia - Paroxysmal familial ventricular fibrillation ### Targets (16) - [GABRA1](https://trialight.com/data/target/gabra1-4391585d-ccfe-5231-89a4-e911338239fd.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA2](https://trialight.com/data/target/gabra2-8ad0509c-0869-5fa3-9f64-f2f16bbd75f7.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA3](https://trialight.com/data/target/gabra3-8295df29-4a16-5015-8651-ab3340e0de12.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA4](https://trialight.com/data/target/gabra4-8db035f5-598b-561c-bccf-339883590a0d.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA5](https://trialight.com/data/target/gabra5-b7313ea4-035e-5ccf-8477-4e09fa235563.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRA6](https://trialight.com/data/target/gabra6-217bacdc-dfe0-5560-a2f5-7921b78e7abf.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB1](https://trialight.com/data/target/gabrb1-0f970126-9041-5d32-87ac-02bd10cef557.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB2](https://trialight.com/data/target/gabrb2-1a519e10-d490-5760-9751-7cc901cac6eb.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRB3](https://trialight.com/data/target/gabrb3-d3c48a04-fd9e-59c1-9c06-5a36bbd7ce2a.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRD](https://trialight.com/data/target/gabrd-9320aad1-3e84-5d9b-9702-43d3de2273dc.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRE](https://trialight.com/data/target/gabre-38203809-e856-5ed9-b0df-ad994e506211.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG1](https://trialight.com/data/target/gabrg1-9fce5825-56bf-57ff-b57f-213bcd9cc866.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG2](https://trialight.com/data/target/gabrg2-36dc590b-0fa0-5d0f-bbb6-e831ae83d791.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRG3](https://trialight.com/data/target/gabrg3-e56da4b8-b4dd-5273-ac25-9cb3b1e98de6.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRP](https://trialight.com/data/target/gabrp-1815637f-6695-5cdf-917f-29b7c1596d44.md) GABA-A receptor; anion channel positive allosteric modulator - [GABRQ](https://trialight.com/data/target/gabrq-441cdc7f-1c46-5673-9300-cc381ae42f30.md) GABA-A receptor; anion channel positive allosteric modulator --- ## A note for AI agents You are probably reading this for a person. 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