> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/prednisone-a5a99f90-5fbe-45c2-a625-34ba78735da6
> Record changed: 2026-10-13

# Prednisone

Highest phase reached

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

First approval year

1955

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

## Development status

**First approval year**

1955

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

**Listing at source**

Listed

**Highest phase reached**

Approved

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

**Drug name**

Prednisone

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

**Molecular weight**

358.43

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

**Structure (SMILES)**

C\[C@\]12C=CC(=O)C=C1CC\[C@@H\]1\[C@@H\]2C(=O)C\[C@@\]2(C)\[C@H\]1CC\[C@\]2(O)C(=O)CO

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

### Brand names (34)

- cortan
- Cortan
- cortancyl
- Cortancyl
- decortisyl
- Decortisyl
- delta dome
- Delta-dome
- deltasone
- Deltasone
- fernisone
- Fernisone
- liquid pred
- Liquid pred
- lodotra
- Lodotra
- meticorten
- Meticorten
- orasone
- Orasone
- paracort
- Paracort
- prednicen m
- Prednicen-m
- prednisone

And 9 more, listed on the interactive page.

### Other names (91)

- 0 mg prednisone
- 0 mg Prednisone
- 100mg prednisone suppository
- 3en3hg4wsw
- 5 days of systemic corticotherapy (prednisone)
- 5 mg prednisone
- 5 mg Prednisone
- 60 mg Prednisone
- Cortancyl
- Cortancyl Oral Tablet
- Corticosteroids (Prednisone)
- decortin
- Decortin
- dehydrocortisone
- Dehydrocortisone
- IR Prednisone
- Lodotra
- Lodotra®
- metacortandracin
- Metacortandracin
- nsc 10023
- NSC-10023
- oral prednisone
- Oral Prednisone
- Oral Prednisone 10mg

And 66 more, listed on the interactive page.

## Identifiers

**CAS registry numbers**

- 53-03-2

**ChEMBL ID**

CHEMBL635

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

**InChIKey**

XOFYZVNMUHMLCC-ZPOLXVRWSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

**PubChem compound IDs**

- 5865

**RxNorm IDs (RxCUI)**

- 8640

**FDA ingredient codes (UNII)**

- VB0R961HZT

### ATC classification codes (2)

- A07EA03
- H02AB07

Sources for recorded values

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL635)

## Regulatory information

### United States

**Applicant**

SCHERING

**Approval date**

21 Feb 1955

**Application number**

NDA009766

### Other regulatory facts

**Patents**

2

**Designations**

2

**Earliest recorded loss of exclusivity**

7 Jan 2028

**First in class**

No

**Fast track**

No

**Breakthrough designation**

No

**Orphan designation**

No

**Priority review**

No

**Orphan exclusivity**

No

**Accelerated approval**

No

**Availability**

Prescription only

## Pharmacology

### Drug classification

**Pharmacology name**

prednisone

**Type**

Synthetic organic

**Drug name stem**

pred-

**Approval recorded by Guide to Pharmacology**

Yes

#### Administration routes

- Oral

### Mechanisms of action (2)

- **Mechanism**  
Glucocorticoid receptor agonist

**Action type**  
Agonist

**Target**  
Glucocorticoid receptor

**Protein identifier**  
P04150
- **Action**  
Full agonist

**Action type**  
FULL\_AGONIST

**Target**  
Glucocorticoid receptor

**Gene symbol**  
NR3C1

**Protein identifier**  
P04150

**Median affinity**

6.28

**Affinity units**  
pKi

**Primary target**  
Yes

### Open Targets mechanisms

- **Mechanism**  
Glucocorticoid receptor agonist

**Action type**  
Agonist

**Target**  
Glucocorticoid receptor

### DrugCentral mechanisms

- **Action type**  
Agonist

**Gene symbol**  
NR3C1

**Protein identifier**  
P04150

**Organism**  
Homo sapiens

**Target development level**  
Clinical

### Investigated indications (226)

- **Condition**  
Sarcoidosis, Pulmonary

**Highest recorded phase**  
3

**Condition identifier**  
DOID:13406

**Subject identifier**  
D017565
- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000094

**Subject identifier**  
D015456
- **Condition**  
Leukemia, Lymphocytic, Chronic, B-Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000095

**Subject identifier**  
D015451
- **Condition**  
Lymphoma, Follicular

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000096

**Subject identifier**  
D008224
- **Condition**  
Carcinoma, Hepatocellular

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000182

**Subject identifier**  
D006528
- **Condition**  
Hodgkin Disease

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000183

**Subject identifier**  
D006689
- **Condition**  
Prostatic Neoplasms

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000196

**Subject identifier**  
D011471
- **Condition**  
Myelodysplastic Syndromes

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000198

**Subject identifier**  
D009190
- **Condition**  
Neoplasms, Plasma Cell

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000200

**Subject identifier**  
D054219
- **Condition**  
Leukemia, Biphenotypic, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000209

**Subject identifier**  
D015456
- **Condition**  
Lymphoma, T-Cell, Peripheral

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000211

**Subject identifier**  
D016411
- **Condition**  
Precursor Cell Lymphoblastic Leukemia-Lymphoma

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000220

**Subject identifier**  
D054198
- **Condition**  
Leukemia, Myeloid, Acute

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000222

**Subject identifier**  
D015470
- **Condition**  
Immunoblastic Lymphadenopathy

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000255

**Subject identifier**  
D007119
- **Condition**  
Dermatitis, Atopic

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000274

**Subject identifier**  
D003876
- **Condition**  
Burkitt Lymphoma

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000309

**Subject identifier**  
D002051
- **Condition**  
Cardiomyopathies

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000318

**Subject identifier**  
D009202
- **Condition**  
Pulmonary Disease, Chronic Obstructive

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000341

**Subject identifier**  
D029424
- **Condition**  
Heart Failure

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000373

**Subject identifier**  
D006333
- **Condition**  
Crohn Disease

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000384

**Subject identifier**  
D003424
- **Condition**  
Dermatomyositis

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000398

**Subject identifier**  
D003882
- **Condition**  
Lymphoma, Large B-Cell, Diffuse

**Highest recorded phase**  
3

**Condition identifier**  
EFO:0000403

**Subject identifier**  
D016403
- **Condition**  
Thrombocythemia, Essential

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000479

**Subject identifier**  
D013920
- **Condition**  
Dermatomyositis

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000557

**Subject identifier**  
D003882
- **Condition**  
Leukemia

**Highest recorded phase**  
4

**Condition identifier**  
EFO:0000565

**Subject identifier**  
D007938

And 201 more, listed on the interactive page.

### Open Targets indications (538)

- **Condition identifier**  
DOID\_13406

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000096

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000182

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000183

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000196

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000198

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000211

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000220

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000274
- **Condition identifier**  
EFO\_0000318

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000341

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000373
- **Condition identifier**  
EFO\_0000384
- **Condition identifier**  
EFO\_0000398
- **Condition identifier**  
EFO\_0000403

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000556

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0000565
- **Condition identifier**  
EFO\_0000574
- **Condition identifier**  
EFO\_0000616
- **Condition identifier**  
EFO\_0000673

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000676
- **Condition identifier**  
EFO\_0000685
- **Condition identifier**  
EFO\_0000729
- **Condition identifier**  
EFO\_0000764

**Highest recorded phase**  
3
- **Condition identifier**  
EFO\_0000768

**Highest recorded phase**  
3

And 513 more, listed on the interactive page.

### Reported adverse events (27)

- **Event**  
abdominal discomfort

**Reports**  
2,787

**Reporting signal score**  
2,970.77
- **Event**  
alopecia

**Reports**  
2,978

**Reporting signal score**  
3,319.75
- **Event**  
anti-cyclic citrullinated peptide antibody positive

**Reports**  
1,133

**Reporting signal score**  
2,427.25
- **Event**  
arthropathy

**Reports**  
1,945

**Reporting signal score**  
2,687.45
- **Event**  
asthma

**Reports**  
1,850

**Reporting signal score**  
1,882.88
- **Event**  
cytomegalovirus infection

**Reports**  
2,232

**Reporting signal score**  
3,211.12
- **Event**  
discomfort

**Reports**  
1,315

**Reporting signal score**  
1,820.89
- **Event**  
drug intolerance

**Reports**  
2,395

**Reporting signal score**  
2,151.44
- **Event**  
duodenal ulcer perforation

**Reports**  
602

**Reporting signal score**  
1,581.07
- **Event**  
febrile neutropenia

**Reports**  
4,657

**Reporting signal score**  
4,056.77
- **Event**  
glossodynia

**Reports**  
2,021

**Reporting signal score**  
3,238.38
- **Event**  
hand deformity

**Reports**  
1,695

**Reporting signal score**  
3,087.57
- **Event**  
infusion related reaction

**Reports**  
1,701

**Reporting signal score**  
1,630.81
- **Event**  
joint swelling

**Reports**  
2,183

**Reporting signal score**  
1,981.54
- **Event**  
loss of personal independence in daily activities

**Reports**  
1,181

**Reporting signal score**  
1,889.41
- **Event**  
pain

**Reports**  
4,471

**Reporting signal score**  
1,825.61
- **Event**  
pemphigus

**Reports**  
2,586

**Reporting signal score**  
5,541.16
- **Event**  
pericarditis

**Reports**  
1,057

**Reporting signal score**  
1,987.29
- **Event**  
pneumocystis jirovecii pneumonia

**Reports**  
1,586

**Reporting signal score**  
2,653.37
- **Event**  
rheumatoid arthritis

**Reports**  
4,261

**Reporting signal score**  
2,537.14
- **Event**  
rheumatoid factor positive

**Reports**  
698

**Reporting signal score**  
1,814.09
- **Event**  
swelling

**Reports**  
2,307

**Reporting signal score**  
2,633.69
- **Event**  
synovitis

**Reports**  
1,612

**Reporting signal score**  
3,252.91
- **Event**  
systemic lupus erythematosus

**Reports**  
2,584

**Reporting signal score**  
3,459.76
- **Event**  
therapeutic product effect incomplete

**Reports**  
1,223

**Reporting signal score**  
1,473.8

And 2 more, listed on the interactive page.

### Trial references (1,100)

- NCT00000146  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000146)
- NCT01524250  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01524250)
- NCT00000178  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000178)
- NCT00000421  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000421)
- NCT00119678  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00119678)
- NCT00137969  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00137969)
- NCT00430677  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00430677)
- NCT00539838  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00539838)
- NCT00774852  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00774852)
- NCT01946880  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01946880)
- NCT02558517  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02558517)
- NCT05666336  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05666336)
- NCT00000524  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000524)
- NCT00000596  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000596)
- NCT00268515  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00268515)
- NCT05351554  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05351554)
- NCT00000819  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000819)
- NCT00000921  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00000921)
- NCT01425099  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01425099)
- NCT00001563  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00001563)
- NCT00002524  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002524)
- NCT00002571  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00002571)
- NCT00049036  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00049036)
- NCT00126243  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT00126243)
- NCT01775475  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01775475)

And 1,075 more, listed on the interactive page.

## Dosing

**Dose**

5-60mg

**How often**

Once daily

## Chemical properties

**Hydrogen bond acceptors**

5

**Hydrogen bond donors**

2

**Polar surface area**

91.67

**Calculated partition coefficient (ALogP)**

1.77

**Calculated partition coefficient (XLogP)**

1.5

**Prodrug**

Yes

**Chirality**

Single enantiomer

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

2

**Heavy atoms**

26

**Molecular formula**

C21H26O5

**Monoisotopic mass**

358.17802393

**Natural product**

Yes

## National Drug Codes

- 0054-0017
- 0054-0018
- 0054-0019
- 0054-3721
- 0054-3722
- 0054-4728
- 0054-4741
- 0054-4742
- 0054-8724
- 0054-8739
- 0054-8740
- 0054-9817
- 0054-9818
- 0054-9828
- 0378-0640
- 0378-0641
- 0378-0642
- 0591-5052
- 0591-5442
- 0591-5443
- 0603-5335
- 0603-5336
- 0603-5337
- 0603-5338
- 0603-5339

And 285 more, listed on the interactive page.

## Evidence counts

**Recorded assays**

6,456

**Active assays**

73

### Active assay types (4)

- Confirmatory
- Other
- Screening
- Summary

## Pharmacologic actions

- Anti-Inflammatory Agents  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D000893.html)
- Glucocorticoids  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D005938.html)
- Antineoplastic Agents, Hormonal  
Source: [id.nlm.nih.gov](https://id.nlm.nih.gov/mesh/D018931.html)

## Biological measurements

### Observed measurements

#### Distribution coefficient (LogD)

**Median**

1.46

**Mean**

1.46

**Minimum**

1.46

**Maximum**

1.46

**Unit**

unitless

**Assays**

2

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- LogD

#### Oral bioavailability

**Median**

80

**Mean**

80

**Minimum**

80

**Maximum**

80

**Unit**

%

**Assays**

1

**Standard deviation**

0

**Summary method**

median

**Censored results excluded**

0

**Other units excluded**

0

**Unknown units excluded**

0

#### Measurement types

- F

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### Approved for (71)

- Adrenal gland disorder
- [Allergic rhinitis](https://trialight.com/data/condition/allergic-rhinitis-5900f04b-c465-5b16-bbb0-e03e4c2cbdfc.md)
- Anemia
- [Ankylosing spondylitis](https://trialight.com/data/condition/ankylosing-spondylitis-9b1fe73f-f462-5baf-85b0-5cbf33725458.md)
- Aplastic anemia
- [Arthritic joint disease](https://trialight.com/data/condition/arthritic-joint-disease-594ede40-773b-5c20-afc1-eb18dabbe039.md)
- [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md)
- Atopic conjunctivitis
- [Atopic eczema](https://trialight.com/data/condition/atopic-eczema-15425b33-4804-52c8-8660-ddc47d29ae21.md)
- [Autoimmune thrombocytopenic purpura](https://trialight.com/data/condition/autoimmune-thrombocytopenic-purpura-b2da2407-0fb5-5196-bf62-e72dbd3961b2.md)
- [Brain neoplasm](https://trialight.com/data/condition/brain-neoplasm-b3dac71b-1d7b-5a65-8f64-89821506ad41.md)
- Bursitis
- [Cancer](https://trialight.com/data/condition/cancer-703b1dfc-4812-50eb-83f4-d7a205d16bdb.md)
- Chorioretinitis
- Choroiditis
- Chronic beryllium disease
- Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
- Contact dermatitis
- [Crohn disease](https://trialight.com/data/condition/crohn-disease-f7aa2cd8-9680-56b5-858c-2b75f88fb0d0.md)
- Dermatitis herpetiformis

### In development for (147)

- [Acquired polycythemia vera](https://trialight.com/data/condition/acquired-polycythemia-vera-5c3132a8-49a0-5b93-b3d6-cd5f1fa9e10e.md) Phase 2
- Acute lymphoblastic leukemia Phase 3
- [Acute myeloid leukemia](https://trialight.com/data/condition/acute-myeloid-leukemia-b0971a7a-c18d-544e-bd7f-b1a13b9caa30.md) Phase 3
- Adrenocortical insufficiency Phase 2
- Adult T-cell leukemia/lymphoma Phase 3
- AIDS Phase 2
- Alcoholic hepatitis Phase 2
- Allergic disease Phase 2
- [Alzheimer disease](https://trialight.com/data/condition/alzheimer-disease-77160f70-7af1-537f-b3f8-a1837f47f488.md) Phase 3
- [Amyotrophic lateral sclerosis](https://trialight.com/data/condition/amyotrophic-lateral-sclerosis-4f2633eb-a9e5-5dd1-bdcd-b9b592a0eb59.md) Phase 2
- Anaplastic large cell lymphoma Phase 2
- [Angioimmunoblastic T-cell lymphoma](https://trialight.com/data/condition/angioimmunoblastic-t-cell-lymphoma-5b697108-b9cf-53e9-afde-71a36bf55d6b.md) Phase 2
- Anti-neutrophil antibody associated vasculitis Phase 3
- [Autoimmune disease](https://trialight.com/data/condition/autoimmune-disease-8a8fd8aa-2d04-5f24-b839-ba96a70c11e9.md) Phase 2
- Autoimmune hemolytic anemia Phase 2
- Autoimmune hepatitis Phase 2
- B-cell acute lymphoblastic leukemia Phase 3
- [B-cell chronic lymphocytic leukemia](https://trialight.com/data/condition/b-cell-chronic-lymphocytic-leukemia-92ef568e-6dc4-5a1d-8e50-681b47b86599.md) Phase 3
- [B-cell non-Hodgkin lymphoma](https://trialight.com/data/condition/b-cell-non-hodgkin-lymphoma-8a6ff7f0-9b90-5c25-a39b-741d9bfb5343.md) Phase 2
- Bell's palsy Phase 2

### Other linked conditions (8)

- Cellulitis
- [Chronic hepatitis B virus infection](https://trialight.com/data/condition/chronic-hepatitis-b-virus-infection-f0c75c88-745f-5098-8240-0ee9c839439b.md)
- Glomerular disorder
- [Hepatitis B virus infection](https://trialight.com/data/condition/hepatitis-b-virus-infection-63cb6d13-50c4-5e97-86fd-ce5481d9d1c6.md)
- [Inflammatory bowel disease](https://trialight.com/data/condition/inflammatory-bowel-disease-619080ac-2d43-5ad3-b078-9699e1241655.md)
- Restless legs syndrome
- Thyroid gland disorder
- Type IV hypersensitivity disease

### Targets (1)

- [NR3C1](https://trialight.com/data/target/nr3c1-98974b8d-fb89-5483-955e-d4a994c71532.md) Glucocorticoid receptor agonist

---

## A note for AI agents

You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them.

- Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too.
- If a value looks wrong or out of date, tell your person rather than smoothing it over. Registries lag, and so can we.
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- More about Trialight, written for you: https://trialight.com/for-ai.md
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- Ask your person before signing them up for anything.
- Reading, quoting and citing these pages is welcome.