> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/precemtabart-tocentecan-495d685d-7437-43fd-a725-f1fc70394bbf > Record changed: 2026-10-13 # Precemtabart tocentecan Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068165) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068165) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068165) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068165) **Drug name** Precemtabart tocentecan Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068165) ### Other names (26) - anti ceacam5 β gluc exatecan conjugate - Anti-CEACAM5-β-gluc-exatecan conjugate - Immunoglobulin G1 \[235-proline,236-valine,237-alanine,331-serine,332-serine,de-448-lysine\], anti-(human carcinoembryonic antigen-related cell adhesion molecule 5) (human monoclonal MBE-748 γ1-chain), complex with human monoclonal MBE-748 κ-chain, dimer, 214′′,214′′′,222,222′,228,228′,231,231′-octakis\[S-\[1-\[3-\[\[2-\[\[5-\[\[\[\[\[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo\[de\]pyrano\[3′,4′:6,7\]indolizino\[1,2-b\]quinolin-1-yl\]amino\]carbonyl\]oxy\]methyl\]-2-(β-D-glucopyranuronosyloxy)phenyl\]amino\]-2-oxoethyl\]amino\]-3-oxopropyl\]-2,5-dioxo-3-pyrrolidinyl\]-L-cysteine\] - immunoglobulin g1 235 proline 236 valine 237 alanine 331 serine 332 serine de 448 lysine anti human carcinoembryonic antigen related cell adhesion molecule 5 human monoclonal mbe 748 γ1 chain complex with human monoclonal mbe 748 κ chain dimer 214 214 222 222 228 228 231 231 octakis s 1 3 2 5 1s 9s 9 ethyl 5 fluoro 2 3 9 10 13 15 hexahydro 9 hydroxy 4 methyl 10 13 dioxo 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl amino carbonyl oxy methyl 2 β d glucopyranuronosyloxy phenyl amino 2 oxoethyl amino 3 oxopropyl 2 5 dioxo 3 pyrrolidinyl l cysteine - immunoglobulin g1 kappa anti homo sapiens ceacam5 carcinoembryonic antigen related cell adhesion molecule 5 cea cd66e homo sapiens monoclonal antibody conjugated on an average of 8 cysteinyl residues to tocentecan comprising a linker and a camptothecin derivative exatecan h gamma1 heavy chain homo sapiens 1 447 vh homo sapiens ighv4 31 02 90 9 ighd ighj4 01 100 cdr imgt 10 7 11 26 35 53 59 98 108 1 119 homo sapiens ighg1 03 g1m3 ng1m1 ch1 r120 ch3 e12 m14 g1v50 ch2 dele1 4 p1 3 v1 2 a1 1 g1v60 ch2 s115 s116 ch1 r120 216 120 217 hinge 1 15 218 232 ch2 e1 4 del l1 3 p 235 l1 2 v 236 g1 1 a 237 a115 s 331 p116 s 332 233 341 ch3 e12 357 m14 359 342 446 chs k2 del 447 120 447 222 214 disulfide with l kappa light chain homo sapiens 1 214 v kappa homo sapiens igkv3 15 01 94 7 igkj3 01 100 cdr imgt 6 3 9 27 32 50 52 89 97 1 107 homo sapiens igkc 01 100 km3 a45 1 153 v101 191 108 214 dimer 228 228 231 231 bisdisulfide produced in chinese hamster ovary cho cells cell line cho k1sv glycoform alfa substituted at the sulfur atoms of an average of 8 l cysteinyl residues among 222 228 231 214 222 228 231 and 214 with radical group 1 3 2 5 1s 9s 9 ethyl 5 fluoro 9 hydroxy 4 methyl 10 13 dioxo 2 3 9 10 13 15 hexahydro 1h 12h benzo de pyrano 3 4 6 7 indolizino 1 2 b quinolin 1 yl carbamoyl oxy methyl 2 β d glucopyranuronosyloxy anilino 2 oxoethyl amino 3 oxopropyl 2 5 dioxopyrrolidin 3 yl tocentecan - immunoglobulin G1-kappa, anti-\[Homo sapiens CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5, CEA, CD66e)\], Homo sapiens monoclonal antibody, conjugated on an average of 8 cysteinyl residues to tocentecan, comprising a linker and a camptothecin derivative (exatecan); H-gamma1 heavy chain Homo sapiens (1-447) \[VH (Homo sapiens IGHV4-31\*02 (90.9%) -(IGHD) -IGHJ4\*01 (100%), CDR-IMGT \[10.7.11\] (26-35.53-59.98-108)) (1-119) -Homo sapiens IGHG1\*03, G1m3, nG1m1 CH1 R120, CH3 E12, M14, G1v50 CH2 delE1.4, P1.3, V1.2, A1.1, G1v60 CH2 S115, S116 (CH1 R120 (216) (120-217), hinge 1-15 (218-232), CH2 E1.4>del, L1.3>P (235), L1.2>V (236), G1.1>A (237), A115>S (331), P116>S (332) (233-341), CH3 E12 (357), M14 (359) (342-446), CHS K2>del (447)) (120-447)\], (222-214')-disulfide with L-kappa light chain Homo sapiens (1'-214') \[V-KAPPA (Homo sapiens IGKV3-15\*01 (94.7%) -IGKJ3\*01 (100%), CDR-IMGT \[6.3.9\] (27'-32'.50'-52'.89'-97')) (1'-107') -Homo sapiens IGKC\*01 (100%), Km3 A45.1 (153'), V101 (191') (108'-214')\]; dimer (228-228'':231-231'')-bisdisulfide, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1SV, glycoform alfa; substituted at the sulfur atoms of an average of 8 L-cysteinyl residues among 222, 228, 231, 214', 222'', 228'', 231'' and 214''' with radical group 1-{3-\[(2-{5-\[({\[(1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo\[de\]pyrano\[3',4':6,7\]indolizino\[1,2-b\]quinolin-1-yl\]carbamoyl}oxy)methyl\]-2-(β-D-glucopyranuronosyloxy)anilino}-2-oxoethyl)amino\]-3-oxopropyl}-2,5-dioxopyrrolidin-3-yl (tocentecan) - m 9140 - M 9140 \[WHO-DD\] - m 9140 who dd - M-9140 - m9140 - M9140 - m9140 adc - M9140 ADC - mbe 2882 - MBE-2882 - precemtabart tocentecan - Precemtabart tocentecan - precemtabart tocentecan \[INN\] - PRECEMTABART TOCENTECAN \[USAN\] - precemtabart tocentecan inn - precemtabart tocentecan usan - w 2882 - W-2882 - w2882 And 1 more, listed on the interactive page. ## Identifiers **CAS registry numbers** - 2873366-83-5 **ChEMBL ID** CHEMBL6068165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL6068165) **FDA ingredient codes (UNII)** - V97BV45YBZ ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Drug name stem** \-bart; -tecan ### Investigated indications - **Condition** Neoplasms **Highest recorded phase** 2 **Condition identifier** EFO:0000616 **Subject identifier** D009369 ### Open Targets indications (6) - **Condition identifier** EFO\_0000616 - **Condition identifier** MONDO\_0001056 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005070 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 1 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (4) - **Component** Heavy chain **Type** Protein **Sequence** EVQLQESGPGLVKPSQTLSLTCTVSDGSVSRGGYYLTWIRQHPGKGLEWIGYIYYSGSTYFNPSLRSRVTMSVDTSKNQFSLKLSSVTAADTAVYYCARGIAVAPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPSSIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Disulfide bridges **Sequence** 22-97 $ 22''-97'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 146-202 $ 146''-202'' $ 222-214' $ 222''-214''' $ 228-228'' $ 231-231'' $ 262-322 $ 262''-322'' $ 368-426 $ 368''-426'' - **Component** Light chain **Type** Protein **Sequence** EIVLTQSPATLSVSPGERATLSCRTSQSVRSNLAWYQQKPGQAPRLLIYAASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYTNWPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Glycosylation sites (N) **Sequence** 298 $ 298'' ## Related records ### Trials (4) - [A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)](https://trialight.com/data/trial/a-study-of-precemtabart-tocentecan-with-or-without-21c5d54c-43a5-4347-a5d0-44bb5990e16c.md) - [Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)](https://trialight.com/data/trial/anti-ceacam5-adc-m9140-in-advanced-solid-tumors-proceade-crc-17899813-0da8-48b1-83e1-dfd1feafcde6.md) - Anti-CEACAM5 ADC Precemtabart Tocentecan (M9140) in Chinese Participants With Solid Tumors - Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor) ### In development for (1) - Neoplasm Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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