> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/prasinezumab-2fbef4fa-88bd-4067-a69d-0bceaec155a4
> Record changed: 2026-11-04

# Prasinezumab

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298077)

Drug type

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298077)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298077)

## Names and chemistry

**Drug type**

Antibody

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298077)

**Drug name**

Prasinezumab

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298077)

### Other names (24)

- humanized igg1 kappa anti alpha synuclein antibody
- HUMANIZED IGG1, KAPPA ANTI-ALPHA-SYNUCLEIN ANTIBODY
- prasinezumab
- Prasinezumab
- prasinezumab \[INN\]
- PRASINEZUMAB \[USAN\]
- Prasinezumab \[WHO-DD\]
- prasinezumab inn
- prasinezumab usan
- prasinezumab who dd
- prx 002
- Prx-002
- prx002
- Prx002
- PRX002
- rg 7935
- RG-7935
- rg7935
- RG7935
- ro 7046015
- RO-7046015
- ro7046015
- Ro7046015
- RO7046015

## Identifiers

**CAS registry numbers**

- 1960462-19-4

**ChEMBL ID**

CHEMBL4298077

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4298077)

**FDA ingredient codes (UNII)**

- P3Z0Z3P1ZI

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

prasinezumab

**Type**

Antibody

**Drug name stem**

\-mab; -mab

### Mechanisms of action (3)

- **Mechanism**  
Alpha-synuclein binding agent

**Action type**  
BINDING\_AGENT

**Target**  
Alpha-synuclein

**Protein identifier**  
P37840
- **Action**  
Binding

**Action type**  
Binding

**Target**  
synuclein alpha

**Gene symbol**  
SNCA

**Protein identifier**  
P37840

**Median affinity**

10.32

**Affinity units**  
pKd
- **Action**  
Binding

**Action type**  
Binding

**Target**  
synuclein alpha

**Gene symbol**  
SNCA

**Protein identifier**  
P37840

**Median affinity**

7.7

**Affinity units**  
pKd

### Open Targets mechanisms

- **Mechanism**  
Alpha-synuclein binding agent

**Action type**  
BINDING AGENT

**Target**  
Alpha-synuclein

### Investigated indications

- **Condition**  
Parkinson Disease

**Highest recorded phase**  
2

**Condition identifier**  
MONDO:0005180

**Subject identifier**  
D010300

### Open Targets indications (2)

- **Condition identifier**  
HP\_0001268

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0005180

**Highest recorded phase**  
3

### Trial references (4)

- NCT02095171  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02095171)
- NCT02157714  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02157714)
- NCT03100149  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03100149)
- NCT04777331  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04777331)

## Chemical properties

**Prodrug**

No

**Chirality**

Single enantiomer

**Inorganic**

No

**Natural product**

No

### Sequences (5)

- **Component**  
Light chain

**Type**  
Protein

**Sequence**  
DIQMTQSPSSLSASVGDRVTITCKSIQTLLYSSNQKNYLAWFQQKPGKAPKLLIYWASIRKSGVPSRFSGSGSGTDFTLTISSLQPEDLATYYCQQYYSYPLTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
- **Component**  
Heavy chain

**Type**  
Protein

**Sequence**  
EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVAS50ISSGGGSTYYPDNVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARGG100AGIDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-296 $ Asn-296''''
- **Component**  
Disulfide bridge location

**Sequence**  
22-96 $ 22''-96'' $ 23'-94' $ 23'''-94''' $ 140'-200' $ 140'''-200''' $ 143-199 $ 143''-199'' $ 219-220' $ 219''-220''' $ 225-225'' $ 228-228'' $ 260-320 $ 260''-320'' $ 366-424 $ 366''-424''
- **Component**  
Glycosylation sites (N)

**Sequence**  
Asn-296 $ Asn-296''

## Related records

### Trials (6)

- [A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-and-safety-of-intravenous-1269a3d8-2519-4b21-a6fc-86cf80a4f5c4.md)
- A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease
- A Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Disease
- Multiple Ascending Dose Study of PRX002 in Patients With Parkinson's Disease
- Prevent Cognitive Decline in GBA-associated Parkinson's Disease
- Single Ascending Dose Study of PRX002 in Healthy Subjects

### In development for (1)

- [Parkinson disease](https://trialight.com/data/condition/parkinson-disease-a117728d-ad75-551b-9b20-fffa9a2305ac.md) Phase 2

### Targets (1)

- [SNCA](https://trialight.com/data/target/snca-968940e0-5926-55a8-b028-b20048e9b01f.md) Alpha-synuclein binding agent

---

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