> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/povorcitinib-e7c92ac5-b499-4404-a902-1fd2c87d8b9e > Record changed: 2026-11-04 # Povorcitinib Highest phase reached Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) Drug type Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) ## Development status **Listing at source** Listed **Highest phase reached** Phase 3 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) ## Names and chemistry **Drug type** Small molecule Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) **Drug name** Povorcitinib Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) **Molecular weight** 507.47 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) **Structure (SMILES)** Cc1n\[nH\]c(C)c1-c1cnn(C2(CC#N)CN(c3cc(F)c(C(=O)N\[C@@H\](C)C(F)(F)F)cc3F)C2)c1 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) ### Other names (13) - incb 054707 - INCB-054707 - incb054707 - Incb054707 - INCB054707 - povorcitinib - Povorcitinib - povorcitinib \[INN\] - POVORCITINIB \[USAN\] - Povorcitinib \[WHO-DD\] - povorcitinib inn - povorcitinib usan - povorcitinib who dd ## Identifiers **CAS registry numbers** - 1637677-22-5 **ChEMBL ID** CHEMBL5095079 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) **InChIKey** MSGYSFWCPOBHEV-AWEZNQCLSA-N Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095079) **PubChem compound IDs** - 86280672 **FDA ingredient codes (UNII)** - N0JWC7RO00 ## Regulatory information ### European Union **Status** opinion **Status date** 17 Sept 2026 **Approved indications** Treatment of active moderate to severe hidradenitis suppurativa (acne inversa) in adults **Product number** EMEA/H/C/006727 **Authorisation holder** Incyte Biosciences Distribution B.V. **Priority medicines scheme** No **Generic** No **Biosimilar** No **Generic medicines** 0 **Biosimilar medicines** 0 **Advanced therapy** No **Conditional approval** No **Additional monitoring** No **Accelerated assessment** No **Exceptional circumstances** No #### Therapeutic areas - Hidradenitis Suppurativa European medicines record Source: [www.ema.europa.eu](https://www.ema.europa.eu/en/medicines/human/EPAR/povofortay) ### Other regulatory facts **First in class** No **Orphan designation** No ## Approval status **European Union (EMA)** Opinion adopted, decision pending ## Pharmacology ### Drug classification **Pharmacology name** povorcitinib **Type** Synthetic organic **Drug name stem** \-tinib ### Mechanisms of action - **Action** Inhibition **Action type** Inhibitor **Target** Janus kinase 1 **Gene symbol** JAK1 **Protein identifier** P23458 **Median affinity** 6.52 **Affinity units** pIC50 ### Investigated indications (4) - **Condition** Vitiligo **Highest recorded phase** 3 **Condition identifier** EFO:0004208 **Subject identifier** D014820 - **Condition** Hidradenitis Suppurativa **Highest recorded phase** 3 **Condition identifier** EFO:1000710 **Subject identifier** D017497 - **Condition** Asthma **Highest recorded phase** 2 **Condition identifier** MONDO:0004979 **Subject identifier** D001249 - **Condition** Prurigo **Highest recorded phase** 1 **Condition identifier** MONDO:0021739 **Subject identifier** D011536 ### Open Targets indications (8) - **Condition identifier** EFO\_0004208 **Highest recorded phase** 3 - **Condition identifier** EFO\_1000710 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0004979 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0006559 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0008661 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0021739 - **Condition identifier** MONDO\_0026045 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0044212 **Highest recorded phase** 2 ### Trial references (10) - NCT03569371 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03569371) - NCT03607487 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03607487) - NCT04476043 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04476043) - NCT05620823 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05620823) - NCT05620836 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05620836) - NCT06212999 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06212999) - NCT04818346 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT04818346) - NCT06113445 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06113445) - NCT06113471 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06113471) - NCT05851443 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05851443) ## Chemical properties **Hydrogen bond acceptors** 6 **Hydrogen bond donors** 2 **Polar surface area** 102.63 **Calculated partition coefficient (ALogP)** 3.98 **Calculated partition coefficient (XLogP)** 3.1 **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Rule-of-five violations** 1 **Rotatable bonds** 6 **Heavy atoms** 36 **Molecular formula** C23H22F5N7O **Monoisotopic mass** 507.18059916 **Natural product** No ## Related records ### Trials (24) - A Placebo-Controlled Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa - A Study of the Safety of INCB054707 in Participants With Hidradenitis Suppurativa - A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics and the Effect of Probenecid on Povorcitinib Pharmacokinetics When Administered Orally to Healthy Adult Participants - A Study to Evaluate Dermal Open-Flow Microperfusion and Plasma Pharmacokinetic Study of Multiple Doses of Oral Povorcitinib or Topical Ruxolitinib Cream in Healthy Adult Participants - A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V1) - A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2) - A Study to Evaluate Skin and Plasma Pharmacokinetic of Multiple Doses of Povorcitinib After Oral Administration in Healthy Participants - A Study to Evaluate the Drug Interaction Between Povorcitinib and the Oral Contraceptive Levonorgestrel/Ethinyl Estradiol in Healthy Adult Females - [A Study to Evaluate the Effect of Povorcitinib on the QT/QTc Interval in Healthy Participants](https://trialight.com/data/trial/a-study-to-evaluate-the-effect-of-povorcitinib-on-the-qt-qtc-19281c8b-d3be-465d-9c77-166b877ae54d.md) - A Study to Evaluate the Efficacy and Safety of INCB054707 in Participants With Prurigo Nodularis - A Study to Evaluate the Efficacy and Safety of INCB054707 in Participants With Vitiligo - A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa - A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa (HS) - A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma - A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN1) - A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Prurigo Nodularis (STOP-PN2) - A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa - A Study to Evaluate the Pharmacokinetics and Safety of INCB054707 in Participants With Normal Hepatic Function and Participants With Hepatic Impairment - A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of INCB054707 - Pharmacokinetics, Safety, and Efficacy of Povorcitinib in Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa ### In development for (6) - [Asthma](https://trialight.com/data/condition/asthma-247437fb-0e60-5885-8a3a-ce40099cea88.md) Phase 2 - Chronic idiopathic urticaria Phase 2 - [Hidradenitis suppurativa](https://trialight.com/data/condition/hidradenitis-suppurativa-c1030a8d-4971-5d31-b030-aa19715eb7a2.md) Phase 3 - Prurigo Phase 1 - Prurigo nodularis Phase 3 - Vitiligo Phase 3 ### Targets (1) - [JAK1](https://trialight.com/data/target/jak1-c22a6fc9-26d6-5daa-a0f4-71cd08b3c5e1.md) --- ## A note for AI agents You are probably reading this for a person. 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