> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/povetacicept-35bc1784-7c86-451c-9e1d-f9af96cfc0f6 > Record changed: 2026-11-04 # Povetacicept Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095306) Drug type Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095306) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095306) ## Names and chemistry **Drug type** Protein Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095306) **Drug name** Povetacicept Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095306) ### Brand names (2) - variant tnf receptor domain - Variant tnf receptor domain ### Other names (16) - 68 110 tumor necrosis factor receptor superfamily protein tnfrsf13b 77 glutamic acid 78 tyrosine 102 aspartic acid human fusion with peptide linker gsggggs fusion with immunoglobulin g1 5 serine 19 alanine 20 glutamic acid 22 alanine de c terminal lysine human γ1 chain c region c terminal fragment dimer - 68-110-Tumor necrosis factor receptor superfamily protein TNFRSF13B \[77-glutamic acid,78-tyrosine,102-aspartic acid\] (human) fusion with peptide linker (GSGGGGS) fusion with immunoglobulin G1 \[5-serine,19-alanine,20-glutamic acid,22-alanine,de-C-terminal-lysine\] (human γ1-chain C-region C-terminal fragment), dimer - alpn 303 - alpn 303 dual baff april fc fusion antagonist - ALPN-303 - ALPN-303 (DUAL BAFF/APRIL Fc Fusion Antagonist) - human TACI (transmembrane activator and CAML interactor, tumor necrosis factor receptor superfamily member 13B, TNFRSF13B, CD267) receptor domain 68-110 fragment (K77>E10, F78>Y11, Y102>D35)-mutant (1-43), fused via a GSG4S peptide linker (44-50) with 232 C-terminal residues of a mutated human immunoglobulin G1 gamma1 heavy chain (51-281) \[Homo sapiens IGHG1\*01, hinge C55>S (51-65), CH2 L69>A, L70>E, G72>A (66-175), CH3 (176-280), CHS K282>del (281)\], (61-61':64-64')-bisdisulfide dimer, produced in Chinese hamster ovary (CHO) cells, cell line CHO-K1 GS-, glycoform alfa - human taci transmembrane activator and caml interactor tumor necrosis factor receptor superfamily member 13b tnfrsf13b cd267 receptor domain 68 110 fragment k77 e10 f78 y11 y102 d35 mutant 1 43 fused via a gsg4s peptide linker 44 50 with 232 c terminal residues of a mutated human immunoglobulin g1 gamma1 heavy chain 51 281 homo sapiens ighg1 01 hinge c55 s 51 65 ch2 l69 a l70 e g72 a 66 175 ch3 176 280 chs k282 del 281 61 61 64 64 bisdisulfide dimer produced in chinese hamster ovary cho cells cell line cho k1 gs glycoform alfa - povetacicept - Povetacicept - povetacicept \[INN\] - POVETACICEPT \[USAN\] - Povetacicept \[WHO-DD\] - povetacicept inn - povetacicept usan - povetacicept who dd ## Identifiers **CAS registry numbers** - 2490217-42-8 **ChEMBL ID** CHEMBL5095306 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL5095306) **FDA ingredient codes (UNII)** - EN2U82XV65 ## Regulatory information ### Other regulatory facts **Patents** 0 **Designations** 2 **First in class** No **Fast track** No **Breakthrough designation** No **Orphan designation** No **Priority review** No **Orphan exclusivity** No **Accelerated approval** No ## Pharmacology ### Drug classification **Pharmacology name** povetacicept **Type** Peptide **Drug name stem** \-cept ### Mechanisms of action (2) - **Action** Binding **Action type** Binding **Target** APRIL **Gene symbol** APRIL **Median affinity** 12 **Affinity units** pKd - **Action** Binding **Action type** Binding **Target** BAFF **Gene symbol** BAFF **Median affinity** 10.23 **Affinity units** pKd ### Investigated indications (3) - **Condition** Purpura, Thrombocytopenic, Idiopathic **Highest recorded phase** 1 **Condition identifier** EFO:0007160 **Subject identifier** D016553 - **Condition** Anemia, Hemolytic, Autoimmune **Highest recorded phase** 1 **Condition identifier** MONDO:0018922 **Subject identifier** D000744 - **Condition** Inflammation **Highest recorded phase** 1 **Condition identifier** MP:0001845 **Subject identifier** D007249 ### Open Targets indications (10) - **Condition identifier** EFO\_0004194 **Highest recorded phase** 3 - **Condition identifier** EFO\_0007160 - **Condition identifier** MONDO\_0005342 **Highest recorded phase** 3 - **Condition identifier** MONDO\_0005556 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0008558 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0015492 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0018922 - **Condition identifier** MONDO\_0018922 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0020108 **Highest recorded phase** 1 - **Condition identifier** MP\_0001845 ### Trial references - NCT05757570 Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05757570) ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (3) - **Component** Glycosylation sites (N) **Sequence** 132 $ 132' - **Component** Sequence **Type** Protein **Sequence** SLSCRKEQGEYYDHLLRDCISCASICGQHPKQCADFCENKLRSGSGGGGSEPKSSDKTHTCPPCPAPEAEGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPOVYTLPPSRDELTKNOVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Disulfide bridges **Sequence** 4-19 $ 4'-19' $ 22-33 $ 22'-33' $ 26-37 $ 26'-37' $ 61-61' $ 64-64' $ 96-156 $ 96'-156' $ 202-260 $ 202'-260' ## Related records ### Trials (9) - A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis - A Phase 3 Open-Label Study of Long-term Treatment With Povetacicept in Adults With Immunoglobulin A Nephropathy - A Phase 3b Study of Participant Experience on Povetacicept Administered Via Autoinjector as Compared to Sibeprenlimab Administered Via Prefilled Syringe - A Study of ALPN-303 in Adult Healthy Volunteers - [A Study to Evaluate the Relative Bioavailability of Povetacicept Formulations and Bioequivalence of Povetacicept Presentations](https://trialight.com/data/trial/a-study-to-evaluate-the-relative-bioavailability-of-aa6e20ca-3b97-4b8c-8186-ae3fdf16c67a.md) - An Open-label Study of Povetacicept in Autoantibody-Associated Glomerular Diseases - An Open-label Study of Povetacicept in Participants With Autoimmune Cytopenias (RUBY-4) - Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN) - Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN) ### In development for (6) - [Anti-neutrophil cytoplasmic antibody-associated vasculitis](https://trialight.com/data/condition/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-a59f9899-4e99-54af-98e3-b03dbdb0192e.md) Phase 1 - Autoimmune hemolytic anemia Phase 1 - Autoimmune thrombocytopenic purpura Phase 1 - Cold agglutinin disease Phase 1 - [IgA glomerulonephritis](https://trialight.com/data/condition/iga-glomerulonephritis-f6f68a56-7253-54d9-9456-5d9ece4d1a52.md) Phase 3 - [Lupus nephritis](https://trialight.com/data/condition/lupus-nephritis-2794deed-1735-531d-b3ca-1e5d38aadc8a.md) Phase 1 --- ## A note for AI agents You are probably reading this for a person. 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