> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/asset/poseltinib-2b61b78e-7758-48f6-8b32-cc7f97dd50ed
> Record changed: 2026-10-13

# Poseltinib

Highest phase reached

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

Drug type

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

## Development status

**Listing at source**

Listed

**Highest phase reached**

Phase 2

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

## Names and chemistry

**Drug type**

Small molecule

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

**Drug name**

Poseltinib

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

**Molecular weight**

470.53

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

**Structure (SMILES)**

C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccoc23)c1

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

### Other names (17)

- glofitamab poseltinib lenalidomide
- hm 71224
- Hm-71224
- hm71224
- HM71224
- ly3337641
- Ly3337641
- LY3337641
- LY3337641 (T1)
- LY3337641 (T2)
- NB02 (Poseltinib)
- poseltinib
- Poseltinib
- poseltinib \[INN\]
- Poseltinib \[WHO-DD\]
- poseltinib inn
- poseltinib who dd

## Identifiers

**CAS registry numbers**

- 1353552-97-2

**ChEMBL ID**

CHEMBL4163691

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

**InChIKey**

LZMJNVRJMFMYQS-UHFFFAOYSA-N

Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4163691)

**PubChem compound IDs**

- 56644522

**FDA ingredient codes (UNII)**

- D01E4B1U35

## Regulatory information

### Other regulatory facts

**First in class**

No

**Orphan designation**

No

## Pharmacology

### Drug classification

**Pharmacology name**

poseltinib

**Type**

Synthetic organic

**Drug name stem**

\-tinib

### Mechanisms of action (3)

- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Janus kinase 3

**Gene symbol**  
JAK3

**Protein identifier**  
P52333

**Median affinity**

7.3

**Affinity units**  
pIC50
- **Action**  
Inhibition

**Action type**  
Inhibitor

**Target**  
Bruton tyrosine kinase

**Gene symbol**  
BTK

**Protein identifier**  
Q06187

**Median affinity**

7.3

**Affinity units**  
pIC50
- **Mechanism**  
Tyrosine-protein kinase BTK inhibitor

**Action type**  
Inhibitor

**Target**  
Tyrosine-protein kinase BTK

**Protein identifier**  
Q06187

### Open Targets mechanisms

- **Mechanism**  
Tyrosine-protein kinase BTK inhibitor

**Action type**  
Inhibitor

**Target**  
Tyrosine-protein kinase BTK

### Investigated indications

- **Condition**  
Arthritis, Rheumatoid

**Highest recorded phase**  
2

**Condition identifier**  
EFO:0000685

**Subject identifier**  
D001172

### Open Targets indications (9)

- **Condition identifier**  
EFO\_0000685

**Highest recorded phase**  
2
- **Condition identifier**  
EFO\_0005952

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0002571

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0008383

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0017604

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018876

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018905

**Highest recorded phase**  
2
- **Condition identifier**  
MONDO\_0018906

**Highest recorded phase**  
1
- **Condition identifier**  
MONDO\_0018908

**Highest recorded phase**  
1

### Trial references (2)

- NCT01765478  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT01765478)
- NCT02628028  
Source: [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT02628028)

## Chemical properties

**Hydrogen bond acceptors**

8

**Hydrogen bond donors**

2

**Polar surface area**

95.76

**Calculated partition coefficient (ALogP)**

4.64

**Calculated partition coefficient (XLogP)**

4.1

**Prodrug**

No

**Chirality**

Achiral

**Inorganic**

No

**Rule-of-five violations**

0

**Rotatable bonds**

7

**Heavy atoms**

35

**Molecular formula**

C26H26N6O3

**Monoisotopic mass**

470.20663871

**Natural product**

No

## Evidence counts

**Recorded assays**

8

**Active assays**

7

### Active assay types (2)

- Confirmatory
- Other

## Related records

### Trials (20)

- 19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers
- A Study in Healthy Male Volunteers to Investigate the Safety and Tolerability of a Single Dose of Neosaxitoxin Alone and in Combination With Bupivacaine (With and Without Epinephrine) for Brachial Plexus Blockade
- A Study in Healthy Men That Tests if Taking BI 1265162 by Mouth, Intravenously, or Inhaled Influences the Amount of BI 1265162 in the Blood
- A Study in Healthy People to Compare 2 Different Formulations of BI 1015550 Taken With or Without Food
- A Study in Healthy People to Test if Taking Different Formulations of BI 425809 Tablets Influences the Amount of BI 425809 in the Blood
- A Study of LY3337641 in Healthy Male Participants
- A Study of LY3337641 in Healthy Participants
- A Study of LY3337641 in Japanese and Caucasian Healthy Participants
- A Study of LY3337641 in Rheumatoid Arthritis
- A Study on Whether Patients Prefer the Spiriva® Respimat® or the Spiriva® Handihaler® for Treating Their Chronic Obstructive Pulmonary Disease (COPD)
- [A Study to Evaluate the Pharmacokinetics Similarity of CBP-201 in Healthy Adult Chinese Subjects](https://trialight.com/data/trial/a-study-to-evaluate-the-pharmacokinetics-similarity-of-cbp-c1ed12bf-ac61-4e69-8494-3352f52f3bab.md)
- Bioavailability and Safety of Two Oral Fixed Dose Preparations Containing 18 mg Ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) Versus Reference Dosing (Weight Based) Containing 6 mg Ivermectin (REVECTINA®, Abbott Laboratórios do Brasil Ltda, Brazil)
- Bioequivalence Study to Compare Selexipag 400 Microgram Film Coated Tablets Versus Uptravi® (Selexipag) 400 Microgram Film Coated Tablets
- Efficacy Study of T2 Versus AZA to Maintain Clinical and Endoscopic Remission in Postoperative Crohn's Disease
- Golcadomide, Poseltinib, and Rituximab for Relapsed/Refractory Diffuse Large B-cell Lymphoma
- GPL in Patients with Relapsed/refractory Diffuse Large B Cell Lymphoma
- NB02(POSELTINIB) Monotherapy in R/R Non-Hodgkin's Lymphoma
- Safety, Tolerability, Pharmacokinetics of Single Rising Oral Doses of BI 1181181 in Healthy Male Volunteers, Including Investigation of the Effect of Food on the Bioavailability of BI 1181181
- Safety,PK/PD, Food Effect Study of Orally Administered HM71224 in Healthy Adult Male Volunteers
- Study of 19(T2)28z1xx TRAC-Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Lymphoma

### In development for (2)

- [Non-Hodgkin lymphoma](https://trialight.com/data/condition/non-hodgkin-lymphoma-9fc07e31-fd30-5055-991f-04d10cc1f646.md) Phase 1
- [Rheumatoid arthritis](https://trialight.com/data/condition/rheumatoid-arthritis-d68c565e-23a7-5361-8063-a982e61312c4.md) Phase 2

### Targets (1)

- [BTK](https://trialight.com/data/target/btk-0715d96c-6e26-5c6e-a6e0-2a745512051d.md) Tyrosine-protein kinase BTK inhibitor

---

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