> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/asset/ponsegromab-eed9d94c-9444-4c31-b7e5-b172d8032862 > Record changed: 2026-10-13 # Ponsegromab Highest phase reached Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650502) Drug type Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650502) ## Development status **Listing at source** Listed **Highest phase reached** Phase 2 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650502) ## Names and chemistry **Drug type** Antibody Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650502) **Drug name** Ponsegromab Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650502) ### Other names (15) - IMMUNOGLOBULIN G1 (237-ALANINE,238-ALANINE,240-ALANINE), ANTI-(HUMAN GROWTH DIFFERENTIATION FACTOR 15) (HUMAN-MUS MUSCULUS MONOCLONAL PF-06946860 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL PF-06946860 .KAPPA.-CHAIN, DIMER - immunoglobulin g1 237 alanine 238 alanine 240 alanine anti human growth differentiation factor 15 human mus musculus monoclonal pf 06946860 gamma 1 chain disulfide with human mus musculus monoclonal pf 06946860 kappa chain dimer - immunoglobulin g1 kappa anti homo sapiens growth differentiation factor 15 nsaid activated gene 1 protein placental bone morphogenic protein human mus musculus monoclonal antibody gamma 1 heavy chain human mus musculus 1 449 vh homo sapiens ighv1 69 01 94 ighd ighj1 01 mus musculus ighv1 4 01 70 ighd ighj4 01 87 8 8 13 1 120 ighg1 03 ch1 r97 k 227 ch2 l4 a 237 l5 a 238 g7 a 240 ch3 k107 del 450 121 449 223 214 disulfide with kappa light chain human mus musculus 1 214 homo sapiens igkv3 11 02 92 igkj1 01 mus musculus igkv18 36 01 77 igkj1 01 83 6 3 9 1 107 homo sapiens igkc 01 108 214 dimer 229 229 232 232 bisdisulfide - IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS GROWTH/DIFFERENTIATION FACTOR 15 (NSAID-ACTIVATED GENE 1 PROTEIN, PLACENTAL BONE MORPHOGENIC PROTEIN)); HUMAN-MUS MUSCULUS MONOCLONAL ANTIBODY; .GAMMA.1 HEAVY CHAIN, HUMAN-MUS MUSCULUS (1-449) (VH (HOMO SAPIENS IGHV1-69\*01 (94%) (IGHD)-IGHJ1\*01) / MUS MUSCULUS IGHV1-4\*01 (70%) (IGHD)-IGHJ4\*01) (87%)) (8.8.13) (1-120)-IGHG1\*03 (CH1(R97>K(227)), CH2(L4>A(237),L5>A(238),G7>A(240)), CH3(K107>DEL(450))) (121-449)) (223-214')-DISULFIDE WITH .KAPPA. LIGHT CHAIN, HUMAN-MUS MUSCULUS (1'-214') (HOMO SAPIENS IGKV3-11\*02 (92%) IGKJ1\*01 / MUS MUSCULUS IGKV18-36\*01 (77%) IGKJ1\*01 (83%)) (6.3.9) (1'-107')-HOMO SAPIENS IGKC\*01 (108'-214')), DIMER (229-229'':232-232'')-BISDISULFIDE - pf 06946860 - Pf-06946860 - PF-06946860 - ponsegromab - Ponsegromab - ponsegromab \[INN\] - PONSEGROMAB \[USAN\] - Ponsegromab \[WHO-DD\] - ponsegromab inn - ponsegromab usan - ponsegromab who dd ## Identifiers **CAS registry numbers** - 2368950-15-4 **ChEMBL ID** CHEMBL4650502 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL4650502) **FDA ingredient codes (UNII)** - GXA6PF0254 ## Regulatory information ### Other regulatory facts **First in class** No **Orphan designation** No ## Pharmacology ### Drug classification **Pharmacology name** ponsegromab **Type** Antibody **Drug name stem** \-mab ### Mechanisms of action - **Action** Inhibition **Action type** Inhibitor **Target** growth differentiation factor 15 **Gene symbol** growth differentiation factor 15 ### Investigated indications - **Condition** Cachexia **Highest recorded phase** 1 **Condition identifier** HP:0004326 **Subject identifier** D002100 ### Open Targets indications (9) - **Condition identifier** EFO\_0003144 **Highest recorded phase** 2 - **Condition identifier** HP\_0002039 **Highest recorded phase** 1 - **Condition identifier** HP\_0004326 - **Condition identifier** HP\_0004326 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005184 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005233 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0005252 **Highest recorded phase** 2 - **Condition identifier** MONDO\_0005575 **Highest recorded phase** 1 - **Condition identifier** MONDO\_0009831 **Highest recorded phase** 1 ## Chemical properties **Prodrug** No **Chirality** Single enantiomer **Inorganic** No **Natural product** No ### Sequences (5) - **Component** Glycosylation sites (N) **Sequence** Asn-300 $ Asn-300'''' - **Component** Heavy chain **Type** Protein **Sequence** QVQLVQSGAEVKKPGSSVKVSCKASGYTFSSYNIDWVRQAPGQGLEWMGGINPIFGTAFYNQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCAREAITTVGAMDHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG - **Component** Light chain **Type** Protein **Sequence** EIVLTQSPATLSLSPGERATLSCRTSQSVHNYLAWYQQKPGQAPRLLIYDASTRADGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQFWSWPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC - **Component** Disulfide bridges **Sequence** 22-96 $ 22''-96'' $ 23'-88' $ 23'''-88''' $ 134'-194' $ 134'''-194''' $ 147-203 $ 147''-203'' $ 214'-223 $ 214'''-223'' $ 229-229'' $ 232-232'' $ 264-324 $ 264''-324'' $ 370-428 $ 370''-428'' - **Component** Glycosylation sites (N) **Sequence** Asn-300 $ Asn-300'' ## Related records ### Trials (8) - [A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue](https://trialight.com/data/trial/a-study-to-learn-about-the-medicine-ponsegromab-in-adults-23f40e37-1f29-42f6-916e-9727b39a29b2.md) - A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Weight Loss - A Study to Learn How the Study Medicine (Ponsegromab) is Changed and Eliminated From Healthy Chinese Adults - Singe Dose Study of PF- 06946860 in Healthy Adult Japanese Participants - Singe Dose, First in Human Study of PF- 06946860 in Healthy Adult Subjects - Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 - Study to Assess the Safety and Tolerability of Repeated Doses of an Investigational New Drug in Patients With Cancer and Cachexia. - Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia ### In development for (1) - [Heart failure](https://trialight.com/data/condition/heart-failure-e230b1c3-ce91-5f80-b80f-81fc353ce5cc.md) Phase 2 --- ## A note for AI agents You are probably reading this for a person. 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